Publications

 

A transcription factor primes the condensin pump.

Gerton JL. J Cell Biol. 2018;217:2233-2234.

 

Regulation of kinetochore configuration during mitosis.

Dhatchinamoorthy K, Mattingly M, Gerton JL. [published ahead of print April 29 2018]. Curr Genet. 2018.

 

Chromatin assembly factor-1 (CAF-1) chaperone regulates Cse4 deposition into chromatin in budding yeast.

Hewawasam GS, Dhatchinamoorthy K, Mattingly M, Seidel C, Gerton JL. Chromatin assembly factor-1 (CAF-1) chaperone regulates Cse4 deposition into chromatin in budding yeast. [published ahead of print May 8 2018]. Nucleic Acids Res. 2018.

 

Mammalian oogenesis and female reproductive aging.

Duncan FE, Gerton JL. Aging (Albany NY). 2018;10:162-163.

 

Integrative structure and functional anatomy of a nuclear pore complex.

Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP. Nature. 2018;555:475-482.

 

Taking cohesin and condensin in context.

Yuen KC, Gerton JL. PLoS Genet. 2018;14:e1007118. doi: 10.1371/journal.pgen.1007118.

 

Cohesin facilitates zygotic genome activation in zebrafish.

Meier M, Grant J, Dowdle A, Thomas A, Gerton J, Collas P, O'Sullivan JM, Horsfield JA. Development. 2018;145:dev156521. 156510.151242/dev.156521.

 

Age-associated dysregulation of protein metabolism in the mammalian oocyte.

Duncan FE, Jasti S, Paulson A, Kelsh JM, Fegley B, Gerton JL. Aging Cell. 2017;16:1381-1393.
Highlighted in KUCC annual report

 

Structural plasticity of the living kinetochore.

Dhatchinamoorthy K, Shivaraju M, Lange JJ, Rubinstein B, Unruh JR, Slaughter BD, Gerton JL. J Cell Biol. 2017;216:3551-3570.

 

DNA replication stress restricts ribosomal DNA copy number.

Salim D, Bradford WD, Freeland A, Cady G, Wang J, Pruitt SC, Gerton JL.  PLoS Genet. 2017;13:e1007006.doi: 10.1371/journal.pgen.1007006.

 

Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters.

Kobe C. Yuen, Brian D. Slaughter, & Jennifer L. Gerton. Science Advances. 2017.

 

Ribosomal DNA copy number loss and sequence variation in cancer.

Baoshan Xu, Hua Li, John M. Perry, Vijay Pratap Singh, Jay Unruh, Zulin Yu, Musinu Zakari, William McDowell, Linheng Li, & Jennifer L. Gerton. PLoS Genetics. 2017.

 

Mms21 SUMO Ligase Activity Promotes Nucleolar Function in Saccharomyces cerevisiae.
Dong Hwan Kim, Bethany Harris, Fei Wang, Chris Seidel, Scott McCroskey, and Jennifer L. Gerton. Genetics. 2016.

 

Using fluorescent reporters in conjunction with cytometry and statistics to assess nuclear accumulation of ribosomal proteins.
Dong-Hwan Kim, Andrew C. Box, Hua Li, and Jennifer L. Gerton. Methods Mol Biol. 2017.

 

Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome.

Baoshan Xu, Madelaine Gogol, Karin Gaudenz, & Jennifer L. Gerton. BMC Genomics, 2016.

 

NIPBL controls RNA biogenesis to prevent activation of the stress kinase PKR.
Kobe C. Yuen, Baoshan Xu, Ian D. Krantz, & Jennifer L. Gerton. Cell Reports, 2015.

 

Cohesin and human disease: lessons from mouse models.

Vijay Pratap Singh & Jennifer L. Gerton. Current Opinion in Cell Biology, 2015.

 

The SMC loader Scc2 promotes ncRNA biogenesis and translational fidelity.
Musinu Zakari, Rhonda Trimble Ross, Allison Peak, Marco Blanchette, Chris Seidel, & Jennifer L. Gerton. PLOS Genetics, 2015.

 

Etiology and pathogenesis of the cohesinopathies.

Musinu Zakari, Kobe Yuen, & Jennifer L. Gerton. WIREs Developmental Biology, 2015.

 

The Q1 SMC loader Scc2 regulates gene expression.

Musinu Zakari & Jennifer L. Gerton. Cell Cycle, 2015.

 

L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome.

Baoshan Xu, Nenja Sowa, Maria E. Cardenas, & Jennifer L. Gerton. Human Molecular Genetics, 2014.

 

Phosphorylation by Casein Kinase 2 Facilitates Psh1 Protein-assisted Degradation of Cse4 Protein.

Geetha Hewawasam, Mark Mattingly, Swaminathan Venkatesh, Ying Zhang, Laurence Florens, Jerry L. Workman, & Jennifer L. Gerton. Journal of Biological Chemistry, 2014.

 

The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription.

Shuai Lu, Kenneth K. Lee, Bethany Harris, Bo Xiong, Tania Bose, Anita Saraf, Gaye Hattem, Laurence Florens, Chris Seidel, & Jennifer L. Gerton. EMBO Reports, 2014.

 

Roberts syndrome: A deficit in acetylated cohesin leads to nucleolar dysfunction.

Baoshan Xu, Shuai Lu, & Jennifer L. Gerton. Rare Diseases, 2014.

 

Cohesion promotes nucleolar structure and function.

Bethany Harris, Tania Bose, Kenneth K. Lee, Fei Wang, Shuai Lu, Rhonda Trimble Ross, Ying Zhang, Sarah L. French, Ann L. Beyer, Brian D. Slaughter, Jay R. Unruh, & Jennifer L. Gerton. Molecular Biology of the Cell, 2013.

 

Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome.
Baoshan Xu, Kenneth K. Lee, Lily Zhang, & Jennifer L. Gerton. PLoS Genetics, 2013.

 

Translational mechanisms at work in the cohesinopathies.

Jennifer L. Gerton. Nucleus, 2012 3(6), 520-5.

 

A genetic screen to discover pathways affecting cohesin function in S. pombe identifies chromatin effectors.

Zhiming Chen, Scott McCroskey, Weichao Guo, Hua Li, & Jennifer L. Gerton. G3, 2012.

 

Cell cycle coupled structural oscillation of centromeric nucleosomes in yeast.

Manjunatha Shivaraju, Jay R. Unruh, Brian D. Slaughter, Mark Mattingly, Judith Berman, Jennifer L. Gerton. Cell, 2012.

 

Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells.

Tania Bose, Kenneth K. Lee, Shuai Lu, Baoshan Xu, Bethany Harris, Brian Slaughter, Jay Unruh, Alexander Garrett, William McDowell, Andrew Box, Hua Li, Allison Peak, Sree Ramachandran, Chris Seidel, & Jennifer L. Gerton. PLoS Genetics, 2012.

 

The dynamics of the Cse4 chaperone Scm3.

Manjunatha Shivaraju & Jennifer L. Gerton. Cell Cycle, 2011.

 

Scm3 is a centromeric nucleosome assembly factor.

Manjunatha Shivaraju, Ray Camahort, Mark Mattingly, & Jennifer L. Gerton. Journal of Biological Chemistry, 2011.

 

Cse4 gets a kiss-of-death from Psh1.

Geetha Hewawasam & Jennifer L. Gerton. Cell Cycle, 2011.

 

Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4.

Geetha Hewawasam, Manjunatha Shivaraju, Mark Mattingly, Swaminathan Venkatesh, Skylar Martin-Brown, Laurence Florens, Jerry L. Workman, & Jennifer L. Gerton. Molecular Cell, 2010.

 

Hos1 is a lysine deacetylase for the Smc3 subunit of cohesin.

Bo Xiong, Shuai Lu, & Jennifer L. Gerton. Current Biology, 2010.

 

Eco1 is important for DNA damage repair in S. cerevisiae.

Shuai Lu, Matthew Goering, Scarlett Gard, Bo Xiong, Adrian J. McNairn, Sue L. Jasperson, & Jennifer L. Gerton. Cell Cycle, 2010.

 

Cohesinopathies, gene expression and chromatin organization.

Tania Bose & Jennifer L. Gerton. Journal of Cell Biology, 2010.

 

Regulators of the cohesin network.

Bo Xiong & Jennifer L. Gerton. Annual Review of Biochemistry, 2010.

 

Cohesinopathy mutations disrupt the subnuclear organization of chromatin.

Scarlett Gard, William Light, Bo Xiong, Tania Bose, Adrian J. McNairn, Bethany Harris, Brian Fleharty, Chris Seidel, Journal of Cell Biology, 2009.

 

Cse4 is part of an octameric nucleosome in budding yeast.

Molecular Cell, 2009.

 

Intersection of ChIP and FLIP: genomic methods to study the dynamics of the cohesin pathway.

Chromosome Research, 2009.

 

Cohesinopathy mutations disrupt the subnuclear organization of chromatin.

Journal of Cell Biology, 2009.

 

Cohesinopathies: one ring, many obligations.

Mutation Research, 2008.

 

The chromosome glue gets a little stickier.

Trends in Genetics, 2008.

 

Enhancing togetherness: Kinetochores and cohesion.

Genes and Development, 2007.

 

Transcription alters chromosomal locations of cohesin in S. cerevisiae

Molecular and Cellular Biology 2007.

 

Scm3 is essential to recruit the histone H3 variant Cse4 to centromeres and to maintain a funcational kinetochore.

Molecular Cell, 2007.

 

The overexpression of a Saccharomyces cerevisiae centromeric histone H3 variant mutant protein leads to a defect in kinetochore biorientation.

Genetics, 2007.

 

Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.

Molecular and Cellular Biology, 2006.

 

A global analysis of the relationship between the binding of the Bas1p transcription factore and meiotic recombination activity in Saccharomyces cerevisiae.

Molecular and Cellular Biology, 2006.

 

Preferential occupancy of histone variant H2AZ at inactive promoters influence local histone modifications and chromatin remodeling.

Proceedings of the National Academy of the Sciences, 2005.

 

Homologous chromosome interactions in meiosis: diversity amidst conservation.

Nature Review. Genetics, 2005.

 

Chromosome cohesion: a cycle of holding together and falling apart.

PLoS Biology 2005.

 

The kinetochore is an enhancer of pericentric cohesin binding.

PLoS Biology 2004.

 

Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae.

PLoS Biology 2004.

 

Mnd1p: a spliced evolutionarily conserved protein required for meiotic recombination.

Proceedings of the National Academy of Sciences, 2002.

 

Meiotic recombination involving heterozygous large insertions in S. cerevisiae: Formation and repair of large, unpaired DNA loops.

Genetics, 2001.

 

Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences, 2000.

 

Stereospecificity of reactions catalyzed by HIV-1 integrase.

Journal of Biological Chemistry, 1999.

 

Effects of mutations in residues near the active site of HIV-1 integrase on specific enzyme-substrate interactions.

Journal of Virology, 1998.

 

The core domain of HIV-1 integrase recognizes key features of its DNA substrates.

Journal of Biological Chemistry, 1997.

 

An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer.

Journal of Biological Chemistry, 1995.

 

Analysis of the defect in DNA and joining in the murine scid mutation.

Molecular and Cellular Biology, 1992.

 

 

 

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