AISSAM IKMI

Senior Research Associate

RESEARCH SUMMARY

 

My research interest lies at the intersection of developmental cell biology and evolution. The goal of my research is to understand how cells integrate complex biological and environmental signals within tissues to direct the development and regeneration of organs, and how such regulatory-mechanisms were deployed during the early evolution of multicellular animals. To address these fundamental questions, I established advanced genetics tools for functional investigation in the cnidarian Nematostella vectensis. This sea anemone not only encompasses fundamental aspects of animal development and regeneration in a single in vivo context, but also occupies a key phylogenetic position for exploring the evolutionary history of early animals.

 

 

EDUCATION

 

Ph.D. Genetics and Developmental Biology, University of Paris XI, France (2008)

M.S. Genetics and Molecular Biology, University of Paris XI, France (2004)

 

 

SELECTED PUBLICATIONS

 

TALEN and CRISPR/Cas9-mediated genome editing in the early branching metazoan Nematostella vectensis

Ikmi, A., McKinney, S.A., Delventhal, K.M., and Gibson, M.C.

Nature Communications. 2014. 5: 5486.

PubMed   PDF   ODR

 

Molecular evolution of the Yap/Yorkie proto-oncogene and elucidation of its core transcriptional program.

Ikmi, A., Gaertner, B., Seidel, C.W., Srivastava, M., Zeitlinger, J. and Gibson, M.C.

Molecular Biology and Evolution. 2014. 31(6): 1375-1390.

PubMed   PDF   ODR

 

Mechanisms of tentacle morphogenesis in the sea anemone, Nematostella vectensis.

Fritz, A.E., Ikmi, A., Seidel, C., Paulson, A., and Gibson, M.C.

Development. 2013. 140: 2212-2223.

PubMed   PDF   ODR

 

Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia.

Meyer E.J., Ikmi A., and Gibson M.C.

Current Biology. 2011. 21: 485-491.

PubMed   PDF

 

Identification and in vivo characterization of NvFP-7R, a developmentally regulated red fluorescent protein of Nematostella vectensis.

Ikmi, A. and Gibson, M.C.

PLoS One. 2010. 5(7): E11807.

PubMed   PDF

 

 

Gibson Lab

1000 East 50th Street

Kansas City, MO 64110

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PubMed   PDF   ODR

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