My research interest lies at the intersection of developmental cell biology and evolution. The goal of my research is to understand how cells integrate complex biological and environmental signals within tissues to direct the development and regeneration of organs, and how such regulatory-mechanisms were deployed during the early evolution of multicellular animals. To address these fundamental questions, I established advanced genetics tools for functional investigation in the cnidarian Nematostella vectensis. This sea anemone not only encompasses fundamental aspects of animal development and regeneration in a single in vivo context, but also occupies a key phylogenetic position for exploring the evolutionary history of early animals.
Ph.D. Genetics and Developmental Biology, University of Paris XI, France (2008)
M.S. Genetics and Molecular Biology, University of Paris XI, France (2004)
TALEN and CRISPR/Cas9-mediated genome editing in the early branching metazoan Nematostella vectensis
Ikmi, A., McKinney, S.A., Delventhal, K.M., and Gibson, M.C.
Nature Communications. 2014. 5: 5486.
Molecular evolution of the Yap/Yorkie proto-oncogene and elucidation of its core transcriptional program.
Ikmi, A., Gaertner, B., Seidel, C.W., Srivastava, M., Zeitlinger, J. and Gibson, M.C.
Molecular Biology and Evolution. 2014. 31(6): 1375-1390.
Mechanisms of tentacle morphogenesis in the sea anemone, Nematostella vectensis.
Fritz, A.E., Ikmi, A., Seidel, C., Paulson, A., and Gibson, M.C.
Development. 2013. 140: 2212-2223.
Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia.
Meyer E.J., Ikmi A., and Gibson M.C.
Current Biology. 2011. 21: 485-491.
Identification and in vivo characterization of NvFP-7R, a developmentally regulated red fluorescent protein of Nematostella vectensis.
Ikmi, A. and Gibson, M.C.
PLoS One. 2010. 5(7): E11807.
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