Epithelial cells are characterized by their remarkable capacity to organize themselves into polarized, adherent tissue. Morphological changes of mitotic cells can potentially be extremely disruptive to epithelial homeostasis (akin to building a brick wall with a subset of round bricks). I am applying my expertise in single cell mechanics in the context of tissue to understand how rapidly proliferating epithelial layer reconciles with the drastic shape changes associated with cell division.
Ph.D. Biophysics, ETH Zurich, Switzerland (2014)
M.Sc. Molecular Bioengineering, TU Dresden, Germany (2008)
Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement.
Ramanathan, S.P., Helenius, J., Stewart, M.P., Cattin, C.J., Hyman, A.A., and Muller, D.J.
Nature Cell Biology. 2015. 17(2): 148-59.
Assay for characterizing the recovery of vertebrate cells for adhesion measurements by single-cell force spectroscopy.
Schubert, R., Strohmeyer, N., Bharadwaj, M., Ramanathan, S.P., Krieg, M., Friedrichs, J., Franz, C.M., and Muller, D.J.
Federation of European Biochemical Societies Letters. 2014. 588(19): 3639-48.
Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding.
Stewart, M.P., Helenius, J., Toyoda, Y., Ramanathan, S.P., Muller, D.J., and Hyman, A.A.
Nature. 2011. 69(7329): 226-30.
Type III restriction enzymes cleave DNA by long-range interaction between sites in both head-to-head and tail-to-tail inverted repeat.
van Aelst, K., Tóth, J., Ramanathan, S.P., Schwarz, F.W., Seidel, R., and Szczelkun, M.D.
Proceedings of the National Academy of Sciences of the United States of America. 2010. 107(20): 9123-8.
Type III restriction enzymes communicate in 1D without looping between their target sites.
Ramanathan S.P., van Aelst, K., Sears, A., Peakman, L.J., Diffin, F.M., Szczelkun, M.D., and Seidel, R.
Proceedings of the National Academy of Sciences of the United States of America. 2009. 106(6): 1748-53
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