SUBU RAMANATHAN

Postdoctoral Research Associate

RESEARCH SUMMARY

 

Epithelial cells are characterized by their remarkable capacity to organize themselves into polarized, adherent tissue. Morphological changes of mitotic cells can potentially be extremely disruptive to epithelial homeostasis (akin to building a brick wall with a subset of round bricks). I am applying my expertise in single cell mechanics in the context of tissue to understand how rapidly proliferating epithelial layer reconciles with the drastic shape changes associated with cell division.

 

 

 

EDUCATION

 

Ph.D. Biophysics, ETH Zurich, Switzerland (2014)

M.Sc. Molecular Bioengineering, TU Dresden, Germany (2008)

 

 

 

SELECTED PUBLICATIONS

 

Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement.

Ramanathan, S.P., Helenius, J., Stewart, M.P., Cattin, C.J., Hyman, A.A., and Muller, D.J.

Nature Cell Biology. 2015. 17(2): 148-59.

PubMed

 

Assay for characterizing the recovery of vertebrate cells for adhesion measurements by single-cell force spectroscopy.

Schubert, R., Strohmeyer, N., Bharadwaj, M., Ramanathan, S.P., Krieg, M., Friedrichs, J., Franz, C.M., and Muller, D.J.

Federation of European Biochemical Societies Letters. 2014. 588(19): 3639-48.

PubMed

 

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding.

Stewart, M.P., Helenius, J., Toyoda, Y., Ramanathan, S.P., Muller, D.J., and Hyman, A.A.

Nature. 2011. 69(7329): 226-30.

PubMed

 

Type III restriction enzymes cleave DNA by long-range interaction between sites in both head-to-head and tail-to-tail inverted repeat.

van Aelst, K., Tóth, J., Ramanathan, S.P., Schwarz, F.W., Seidel, R., and Szczelkun, M.D.

Proceedings of the National Academy of Sciences of the United States of America. 2010. 107(20): 9123-8.

PubMed

 

Type III restriction enzymes communicate in 1D without looping between their target sites.

Ramanathan S.P., van Aelst, K., Sears, A., Peakman, L.J., Diffin, F.M., Szczelkun, M.D., and Seidel, R.

Proceedings of the National Academy of Sciences of the United States of America. 2009. 106(6): 1748-53

PubMed

 

 

 

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