Metabolic regulation of HSC function
Metabolism plays a critical role not only in stem cell maintenance but also in stem cell activation and differentiation when coupled with metabolic switches. Understanding the metabolism in primitive HSCs will provide insight into HSC maintenance and improve ex vivo expansion.
In our study, we found that deeply quiescent (reserveModel of metabolic state in reserve and primed HSCs. Image by Zhenrui Li.) HSCs are kept in a low metabolic state, and the underlying detailed mechanism is under investigation. Like normal stem cells, drug resistant cancer stem cells (CSCs) exploit metabolic reprogramming to survive chemotherapy, such as switching from glycolysis to oxidative phosphorylation in oncogene ablation-resistant pancreatic cancer cells. Our lab has a long-term interest in studying leukemia stem cells, and characterizing metabolic preferences in CSCs will provide potential targets for medical treatment and facilitate developing new treatment methods.
Model of metabolic state in reserve and primed HSCs.
Image by Zhenrui Li.