The goal of our research is to develop label free quantitative proteomic tools with a particular focus on applying these tools to the analysis of transcriptional regulatory complexes and protein interaction networks. Our research is focused on multiprotein complexes. Using affinity purification coupled with MudPIT we analyze complexes using different tagged subunits from the same multiprotein complex. This allows us to determine the relative abundance of particular proteins in a complex.
We are a highly interactive and interdisciplinary group, and we collaborate extensively with many researchers at the Stowers Institute, as well as a number of external collaborators.