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Mike Washburn, Director of Proteomics

Laurence Florens, Head Proteomics

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The goal of our research is to develop label free quantitative proteomic tools with a particular focus on applying these tools to the analysis of transcriptional regulatory complexes and protein interaction networks. Our research is focused on multiprotein complexes. Using affinity purification coupled with MudPIT we analyze complexes using different tagged subunits from the same multiprotein complex. This allows us to determine the relative abundance of particular proteins in a complex.

We are a highly interactive and interdisciplinary group, and we collaborate extensively with many researchers at the Stowers Institute, as well as a number of external collaborators.

Latest News

Sardiu ME, Gilmore JM, Groppe B, Florens L, Washburn MP. (2017) Identification of Topological Network Modules in Perturbed Protein Interaction Networks. Scientific Reports. Mar 8;7:43845. Abstract

​Miah S, Banks CAS, Adams MK, Florens L, Lukong KE, & Washburn MP. (2016) Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer. Mol BioSyst. 15(3):960-74 Dec 20;13(1):42-55. Abstract

Banks CAS, Boanca G, Lee ZT, Eubanks CG, Hattem GL, Peak A, Weems LE, Conkright JJ, Florens L, & Washburn MP. (2016) TNIP2 is a hub protein in the NF-κB network with both protein and RNA mediated interactions. Mol Cell Proteomics. Nov 15(11):3435-3449. Abstract

Haynes PA, Stein SE, Washburn MP. (2016) Data quality issues in proteomics - there are many paths to enlightenment. Proteomics. Proteomics. Sep 16(18):2433-4. Abstract