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Mike Washburn, Director of Proteomics

Laurence Florens, Head Proteomics

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The goal of our research is to develop label free quantitative proteomic tools with a particular focus on applying these tools to the analysis of transcriptional regulatory complexes and protein interaction networks. Our research is focused on multiprotein complexes. Using affinity purification coupled with MudPIT we analyze complexes using different tagged subunits from the same multiprotein complex. This allows us to determine the relative abundance of particular proteins in a complex.

We are a highly interactive and interdisciplinary group, and we collaborate extensively with many researchers at the Stowers Institute, as well as a number of external collaborators.

Latest News

Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G, Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L, Washburn MP. (2016) WDR76 co-localizes with heterochromatin related proteins and rapidly responds to DNA damage. PLoS ONE. Jun 1;11(6):e0155492. Abstract

Lakshminarasimhan M, Boanca G, Banks CAS, Gabriel AE, Groppe BD, Hattem G, Smoyer C, Malanowski KE, Peak A, Florens L, Washburn MP. (2016) Proteomic and Genomic Analyses of the Rvb1 and Rvb2 Interaction Network upon Deletion of R2TP Complex Components. Mol Cell Proteomics. 15(3):960-74 [Epub 2016 Feb 1]. Abstract

Washburn MP, Zhao Y, Garcia BA. (2016) Reshaping the Chromatin and Epigenetic Landscapes with Quantitative Mass Spectrometry. Mol Cell Proteomics. 15(3):753-4. Abstract