Microtubules are found in every eukaryotic cell and are one of the primary components of the cytoskeleton. As such, it is without surprise that they are essential for numerous different processes within the cell, including cell division, transportation of critical cellular components, maintenance of cell shape, and the formation of cilia/flagellum. Disrupting the formation of the microtubule-based axoneme results in primary ciliary dyskinesia, a disease that can lead to a number of conditions including chronic respiratory disorders, mislocalization of organs, and sterility. During gametogenesis, it is well-known that microtubules are critical for the proper formation of the axoneme and successful completion of spermatogenesis. My aim is to fully elucidate the role of microtubules throughout spermatogenesis and the impact they have on male fertility.
BS Cell Biology, University of Kansas (2010)
Discovery of supernumerary B chromosomes in Drosophila melanogaster.
, Hughes, S.E., Vietti, D.R., Miller, D.E., McDowell, W., and Hawley, R.S.
. 2014. 196(4): 1007-16.
Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes.
Hughes, S.E., Beeler, J.S., Seat, A., Slaughter, B.D., Unruh, J.R., Bauerly, E.
, Matthies, H.J., and Hawley, R.S.
. 2011. 7(8):e1002209.PubMed