Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L. Cell Rep. 2021;36:109674.
Original Data
Proteome plasticity in response to persistent environmental change
Domnauer M, Zheng F, Li L, Zhang Y, Chang CE, Unruh JR, Conkright-Fincham J, McCroskey S, Florens L, Zhang Y, Seidel C, Fong B, Schilling B, Sharma R, Ramanathan A, Si K, Zhou C. Mol Cell. 2021;81:3294-3309 e3212.
Original Data
Double emulsions with ultrathin shell by microfluidic step-emulsification
Ge X, Rubinstein BY, He Y, Bruce FNO, Li L, Leshansky AM, Li Z. [published ahead of print March 9 2021]. Lab Chip. 2021.
b-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells
Tao F, Soffers J, Hu D, Chen S, Gao X, Zhang Y, Zhao C, Smith SE, Unruh JR, Zhang D, Tsuchiya D, Venkatraman A, Zhao M, Li Z, Qian P, Parmely T, He XC, Washburn M, Florens L, Perry JM, Zeitlinger J, Workman J, Li L. Stem Cell Rep. 2020;15:662-676.
Original Data
FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling
Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X. BMC Biol. 2020;18:87. https://doi.org/10.1186/s12915-12020-00813-12914.
Overcoming Wnt-beta-catenin dependent anticancer therapy resistance in leukaemia stem cells
Perry JM, Tao F, Roy A, Lin T, He XC, Chen S, Lu X, Nemechek J, Ruan L, Yu X, Dukes D, Moran A, Pace J, Schroeder K, Zhao M, Venkatraman A, Qian P, Li Z, Hembree M, Paulson A, He Z, Xu D, Tran TH, Deshmukh P, Nguyen CT, Kasi RM, Ryan R, Broward M, Ding S, Guest E, August K, Gamis AS, Godwin A, Sittampalam GS, Weir SJ, Li L. Nat Cell Biol. 2020;22:689-700
Original Data
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656.
Original Data
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell.2018;22:740-754 e747.
Original Data
Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Cell Res.2018.
Author Correction: Cell Res 2018:1-14. https://doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917.
Original Data
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.
Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. Cell Stem Cell.2016;18:214-228.
Original Data | Journal Cover | Featured in: Serrano-Lopez J, Cancelas JA. Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence. Cell Stem Cell.2016;18:158-160.
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.
Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Nat Med.2014;20:1321-1326.
News & Views
Original Data
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.
Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. Nature. 2013;500:345-349.
Featured in: Goodell MA. Parental Permissions: H19 and Keeping the Stem Cell Progeny under Control. Cell Stem Cell.2013;13:137-138.
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.
Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, Li L. Gastroenterology.2013;145:383-395 e321.
Original Data
Featured in: Lowe AW, Moseley RH. Covering the cover. Gastroenterology.2013;145:263-265.
FGF signaling facilitates post-injury recovery of mouse hematopoietic system.
Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L. Blood.2012;120:1831-1842.
Noncanonical wnt signaling maintains hematopoietic stem cells in the niche.
Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Cell. 2012;150:351-365.
Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.
Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Genes Dev.2011;25:1928-1942.
Journal Cover | Original Data
Coexistence of quiescent and active adult stem cells in mammals.
Li L, Clevers H. Science.2010;327:542-545.
Detection of functional hematopoietic stem cell niche using ex vivo real-time imaging.
Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Nature.2009;457:97-101.
Editor's Summary.
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells.
Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. Cell Stem Cell.2008;2:367-379.
Highlight.
Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis.
Perry JM, Li L. Genes Dev.2008;22:1107-1109.
Disrupting the stem cell niche: good seeds in bad soil.
Perry JM, Li L. Cell.2007;129:1045-1047.
PTEN-deficient intestinal stem cells initiate intestinal polyposis.
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. Nat Genet.2007;39:189-198.
Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion.
Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Stem Cells.2006;24:2826-2839.
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.
Cover, News & Views, and corrected Sup-Fig.4.
Finding the hematopoietic stem cell niche in the placenta.
Li L. Dev Cell.2005;8:297-298.
Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt.
Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. Proc Natl Acad Sci U S A.2004;101:15370-15375.
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-atenin signaling.
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. Nat Genet.2004;36:1117-1121.
The comments regarding this paper News and Views.
Identification of the haematopoietic stem cell niche and control of the niche size.
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L.
Nature. 2003;425:836-841.
A Featured Article. by Nature.
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis.
Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J and Li L. Blood. 2003;101.2:383-389.
The comments regarding this paper Comments.
Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells.
Park I, He Y, Lin F, Laerum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X, Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, Li L. Blood. 2002;99:488-498.
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. Proc Natl Acad Sci USA. 2001;98:7934-7939.
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
Li L, Milner L, Deng Y, Iwata W, Banta A, Graf L, Marcovina S, Friedman C, Trask B, Hood L, Torok-Storb B.Immunity. 1998;8:43-55.
Alagille syndrome is caused by mutations in hJagged1 (JAG1), which encodes a ligand for Notch1.
Li L, Krantz ID, Deng Y, Genin A, Banta A, Collins C, Qi M, Trask BJ, Kuo W, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli D, Hood L, Spinner N. NatGenet. 1997;16:243-251.
Myc represses transcription of the growth arrest gene gas-1.
Lee TC, Li L, Philipson L, Ziff EB. Proc Natl Acad Sci USA. 1997;94:12886-12891.
c-Myc represses transcription by a novel mechanism dependent on the initiator element and Myc box II.
Li L, Nerlov C, Prendergast G, MacGregor D, Ziff EB.
EMBO J. 1994;13:4070-4079.
Invited Reviews, Previews, and Book Chapters
Current view: intestinal stem cells and signaling.
Scoville DH, Sato T, He XC, Li L. Gastroenterology.2008;134:849-864.
Intestinal Stem Cells in Physiologic Regeneration and Disease.
Scoville DH, He XC, Lee G, Sato T, Barrett TA, Li L. In: Principles of Developmental Genetics. 1st Ed. Burlington, MA: Elsevier Inc., Academic Press; 2007.
The stem cell niches in bone.
Yin T, Li L. J Clin Invest.2006;116:1195-1201.
Normal stem cells and cancer stem cells: the niche matters.
Li L, Neaves WB. Cancer Res.2006;66:4553-4557.
Recent advances in understanding extrinsic control of hematopoietic stem cell fate.
Ross J, Li L. Curr Opin Hematol.2006;13:237-242.
Understanding hematopoietic stem-cell microenvironments.
Li Z, Li L. Trends Biochem Sci.2006;31:589-595.
Stem cell niche: structure and function.
Li L, Xie T. Annu Rev Cell Dev Biol.2005;21:605-631.
Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior.
He XC, Zhang J, Li L. Ann N Y Acad Sci.2005;1049:28-38.
BMP signaling and stem cell regulation.
Zhang J, Li L. Dev Biol.2005;284:1-11.
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L. Cell Rep. 2021;36:109674.
Original Data
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656.
Original Data
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell.2018;22:740-754 e747.
Original Data
Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Cell Res.2018.
Author Correction: Cell Res 2018:1-14. https://doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917.
Original Data
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.
Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. Cell Stem Cell.2016;18:214-228.
Original Data | Journal Cover | Featured in: Serrano-Lopez J, Cancelas JA. Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence. Cell Stem Cell.2016;18:158-160.
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.
Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Nat Med.2014;20:1321-1326.
News & Views
Original Data
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.
Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. Nature. 2013;500:345-349.
Featured in: Goodell MA. Parental Permissions: H19 and Keeping the Stem Cell Progeny under Control. Cell Stem Cell.2013;13:137-138.
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.
Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, Li L. Gastroenterology.2013;145:383-395 e321.
Original Data
Featured in: Lowe AW, Moseley RH. Covering the cover. Gastroenterology.2013;145:263-265.
FGF signaling facilitates post-injury recovery of mouse hematopoietic system.
Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L. Blood.2012;120:1831-1842.
Noncanonical wnt signaling maintains hematopoietic stem cells in the niche.
Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Cell. 2012;150:351-365.
Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.
Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Genes Dev.2011;25:1928-1942.
Journal Cover | Original Data
Coexistence of quiescent and active adult stem cells in mammals.
Li L, Clevers H. Science.2010;327:542-545.
Detection of functional hematopoietic stem cell niche using ex vivo real-time imaging.
Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Nature.2009;457:97-101.
Editor's Summary.
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells.
Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. Cell Stem Cell.2008;2:367-379.
Highlight.
Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis.
Perry JM, Li L. Genes Dev.2008;22:1107-1109.
Disrupting the stem cell niche: good seeds in bad soil.
Perry JM, Li L. Cell.2007;129:1045-1047.
PTEN-deficient intestinal stem cells initiate intestinal polyposis.
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. Nat Genet.2007;39:189-198.
Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion.
Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Stem Cells.2006;24:2826-2839.
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.
Cover, News & Views, and corrected Sup-Fig.4.
Finding the hematopoietic stem cell niche in the placenta.
Li L. Dev Cell.2005;8:297-298.
Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt.
Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. Proc Natl Acad Sci U S A.2004;101:15370-15375.
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-atenin signaling.
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. Nat Genet.2004;36:1117-1121.
The comments regarding this paper News and Views.
Identification of the haematopoietic stem cell niche and control of the niche size.
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L.
Nature. 2003;425:836-841.
A Featured Article. by Nature.
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis.
Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J and Li L. Blood. 2003;101.2:383-389.
The comments regarding this paper Comments.
Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells.
Park I, He Y, Lin F, Laerum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X, Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, Li L. Blood. 2002;99:488-498.
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. Proc Natl Acad Sci USA. 2001;98:7934-7939.
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
Li L, Milner L, Deng Y, Iwata W, Banta A, Graf L, Marcovina S, Friedman C, Trask B, Hood L, Torok-Storb B.Immunity. 1998;8:43-55.
Alagille syndrome is caused by mutations in hJagged1 (JAG1), which encodes a ligand for Notch1.
Li L, Krantz ID, Deng Y, Genin A, Banta A, Collins C, Qi M, Trask BJ, Kuo W, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli D, Hood L, Spinner N. NatGenet. 1997;16:243-251.
Myc represses transcription of the growth arrest gene gas-1.
Lee TC, Li L, Philipson L, Ziff EB. Proc Natl Acad Sci USA. 1997;94:12886-12891.
c-Myc represses transcription by a novel mechanism dependent on the initiator element and Myc box II.
Li L, Nerlov C, Prendergast G, MacGregor D, Ziff EB.
EMBO J. 1994;13:4070-4079.
Invited Reviews, Previews, and Book Chapters
Current view: intestinal stem cells and signaling.
Scoville DH, Sato T, He XC, Li L. Gastroenterology.2008;134:849-864.
Intestinal Stem Cells in Physiologic Regeneration and Disease.
Scoville DH, He XC, Lee G, Sato T, Barrett TA, Li L. In: Principles of Developmental Genetics. 1st Ed. Burlington, MA: Elsevier Inc., Academic Press; 2007.
The stem cell niches in bone.
Yin T, Li L. J Clin Invest.2006;116:1195-1201.
Normal stem cells and cancer stem cells: the niche matters.
Li L, Neaves WB. Cancer Res.2006;66:4553-4557.
Recent advances in understanding extrinsic control of hematopoietic stem cell fate.
Ross J, Li L. Curr Opin Hematol.2006;13:237-242.
Understanding hematopoietic stem-cell microenvironments.
Li Z, Li L. Trends Biochem Sci.2006;31:589-595.
Stem cell niche: structure and function.
Li L, Xie T. Annu Rev Cell Dev Biol.2005;21:605-631.
Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior.
He XC, Zhang J, Li L. Ann N Y Acad Sci.2005;1049:28-38.
BMP signaling and stem cell regulation.
Zhang J, Li L. Dev Biol.2005;284:1-11.
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L. Cell Rep. 2021;36:109674.
Original Data
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656.
Original Data
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell.2018;22:740-754 e747.
Original Data
Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Cell Res.2018.
Author Correction: Cell Res 2018:1-14. https://doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917.
Original Data
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.
Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. Cell Stem Cell.2016;18:214-228.
Original Data | Journal Cover | Featured in: Serrano-Lopez J, Cancelas JA. Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence. Cell Stem Cell.2016;18:158-160.
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.
Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Nat Med.2014;20:1321-1326.
News & Views
Original Data
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.
Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. Nature. 2013;500:345-349.
Featured in: Goodell MA. Parental Permissions: H19 and Keeping the Stem Cell Progeny under Control. Cell Stem Cell.2013;13:137-138.
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.
Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, Li L. Gastroenterology.2013;145:383-395 e321.
Original Data
Featured in: Lowe AW, Moseley RH. Covering the cover. Gastroenterology.2013;145:263-265.
FGF signaling facilitates post-injury recovery of mouse hematopoietic system.
Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L. Blood.2012;120:1831-1842.
Noncanonical wnt signaling maintains hematopoietic stem cells in the niche.
Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Cell. 2012;150:351-365.
Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.
Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Genes Dev.2011;25:1928-1942.
Journal Cover | Original Data
Coexistence of quiescent and active adult stem cells in mammals.
Li L, Clevers H. Science.2010;327:542-545.
Detection of functional hematopoietic stem cell niche using ex vivo real-time imaging.
Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Nature.2009;457:97-101.
Editor's Summary.
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells.
Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. Cell Stem Cell.2008;2:367-379.
Highlight.
Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis.
Perry JM, Li L. Genes Dev.2008;22:1107-1109.
Disrupting the stem cell niche: good seeds in bad soil.
Perry JM, Li L. Cell.2007;129:1045-1047.
PTEN-deficient intestinal stem cells initiate intestinal polyposis.
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. Nat Genet.2007;39:189-198.
Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion.
Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Stem Cells.2006;24:2826-2839.
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.
Cover, News & Views, and corrected Sup-Fig.4.
Finding the hematopoietic stem cell niche in the placenta.
Li L. Dev Cell.2005;8:297-298.
Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt.
Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. Proc Natl Acad Sci U S A.2004;101:15370-15375.
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-atenin signaling.
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. Nat Genet.2004;36:1117-1121.
The comments regarding this paper News and Views.
Identification of the haematopoietic stem cell niche and control of the niche size.
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L.
Nature. 2003;425:836-841.
A Featured Article. by Nature.
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis.
Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J and Li L. Blood. 2003;101.2:383-389.
The comments regarding this paper Comments.
Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells.
Park I, He Y, Lin F, Laerum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X, Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, Li L. Blood. 2002;99:488-498.
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. Proc Natl Acad Sci USA. 2001;98:7934-7939.
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
Li L, Milner L, Deng Y, Iwata W, Banta A, Graf L, Marcovina S, Friedman C, Trask B, Hood L, Torok-Storb B.Immunity. 1998;8:43-55.
Alagille syndrome is caused by mutations in hJagged1 (JAG1), which encodes a ligand for Notch1.
Li L, Krantz ID, Deng Y, Genin A, Banta A, Collins C, Qi M, Trask BJ, Kuo W, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli D, Hood L, Spinner N. NatGenet. 1997;16:243-251.
Myc represses transcription of the growth arrest gene gas-1.
Lee TC, Li L, Philipson L, Ziff EB. Proc Natl Acad Sci USA. 1997;94:12886-12891.
c-Myc represses transcription by a novel mechanism dependent on the initiator element and Myc box II.
Li L, Nerlov C, Prendergast G, MacGregor D, Ziff EB.
EMBO J. 1994;13:4070-4079.
Invited Reviews, Previews, and Book Chapters
Current view: intestinal stem cells and signaling.
Scoville DH, Sato T, He XC, Li L. Gastroenterology.2008;134:849-864.
Intestinal Stem Cells in Physiologic Regeneration and Disease.
Scoville DH, He XC, Lee G, Sato T, Barrett TA, Li L. In: Principles of Developmental Genetics. 1st Ed. Burlington, MA: Elsevier Inc., Academic Press; 2007.
The stem cell niches in bone.
Yin T, Li L. J Clin Invest.2006;116:1195-1201.
Normal stem cells and cancer stem cells: the niche matters.
Li L, Neaves WB. Cancer Res.2006;66:4553-4557.
Recent advances in understanding extrinsic control of hematopoietic stem cell fate.
Ross J, Li L. Curr Opin Hematol.2006;13:237-242.
Understanding hematopoietic stem-cell microenvironments.
Li Z, Li L. Trends Biochem Sci.2006;31:589-595.
Stem cell niche: structure and function.
Li L, Xie T. Annu Rev Cell Dev Biol.2005;21:605-631.
Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior.
He XC, Zhang J, Li L. Ann N Y Acad Sci.2005;1049:28-38.
BMP signaling and stem cell regulation.
Zhang J, Li L. Dev Biol.2005;284:1-11.
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656.
Original Data
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656.
Original Data
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell.2018;22:740-754 e747.
Original Data
Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Cell Res.2018.
Author Correction: Cell Res 2018:1-14. https://doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917.
Original Data
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.
Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. Cell Stem Cell.2016;18:214-228.
Original Data | Journal Cover | Featured in: Serrano-Lopez J, Cancelas JA. Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence. Cell Stem Cell.2016;18:158-160.
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.
Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Nat Med.2014;20:1321-1326.
News & Views
Original Data
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.
Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. Nature. 2013;500:345-349.
Featured in: Goodell MA. Parental Permissions: H19 and Keeping the Stem Cell Progeny under Control. Cell Stem Cell.2013;13:137-138.
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.
Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, Li L. Gastroenterology.2013;145:383-395 e321.
Original Data
Featured in: Lowe AW, Moseley RH. Covering the cover. Gastroenterology.2013;145:263-265.
FGF signaling facilitates post-injury recovery of mouse hematopoietic system.
Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L. Blood.2012;120:1831-1842.
Noncanonical wnt signaling maintains hematopoietic stem cells in the niche.
Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Cell. 2012;150:351-365.
Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.
Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Genes Dev.2011;25:1928-1942.
Journal Cover | Original Data
Coexistence of quiescent and active adult stem cells in mammals.
Li L, Clevers H. Science.2010;327:542-545.
Detection of functional hematopoietic stem cell niche using ex vivo real-time imaging.
Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Nature.2009;457:97-101.
Editor's Summary.
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells.
Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. Cell Stem Cell.2008;2:367-379.
Highlight.
Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis.
Perry JM, Li L. Genes Dev.2008;22:1107-1109.
Disrupting the stem cell niche: good seeds in bad soil.
Perry JM, Li L. Cell.2007;129:1045-1047.
PTEN-deficient intestinal stem cells initiate intestinal polyposis.
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. Nat Genet.2007;39:189-198.
Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion.
Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Stem Cells.2006;24:2826-2839.
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.
Cover, News & Views, and corrected Sup-Fig.4.
Finding the hematopoietic stem cell niche in the placenta.
Li L. Dev Cell.2005;8:297-298.
Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt.
Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. Proc Natl Acad Sci U S A.2004;101:15370-15375.
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-atenin signaling.
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. Nat Genet.2004;36:1117-1121.
The comments regarding this paper News and Views.
Identification of the haematopoietic stem cell niche and control of the niche size.
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L.
Nature. 2003;425:836-841.
A Featured Article. by Nature.
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis.
Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J and Li L. Blood. 2003;101.2:383-389.
The comments regarding this paper Comments.
Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells.
Park I, He Y, Lin F, Laerum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X, Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, Li L. Blood. 2002;99:488-498.
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. Proc Natl Acad Sci USA. 2001;98:7934-7939.
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
Li L, Milner L, Deng Y, Iwata W, Banta A, Graf L, Marcovina S, Friedman C, Trask B, Hood L, Torok-Storb B.Immunity. 1998;8:43-55.
Alagille syndrome is caused by mutations in hJagged1 (JAG1), which encodes a ligand for Notch1.
Li L, Krantz ID, Deng Y, Genin A, Banta A, Collins C, Qi M, Trask BJ, Kuo W, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli D, Hood L, Spinner N. NatGenet. 1997;16:243-251.
Myc represses transcription of the growth arrest gene gas-1.
Lee TC, Li L, Philipson L, Ziff EB. Proc Natl Acad Sci USA. 1997;94:12886-12891.
c-Myc represses transcription by a novel mechanism dependent on the initiator element and Myc box II.
Li L, Nerlov C, Prendergast G, MacGregor D, Ziff EB.
EMBO J. 1994;13:4070-4079.
Invited Reviews, Previews, and Book Chapters
Current view: intestinal stem cells and signaling.
Scoville DH, Sato T, He XC, Li L. Gastroenterology.2008;134:849-864.
Intestinal Stem Cells in Physiologic Regeneration and Disease.
Scoville DH, He XC, Lee G, Sato T, Barrett TA, Li L. In: Principles of Developmental Genetics. 1st Ed. Burlington, MA: Elsevier Inc., Academic Press; 2007.
The stem cell niches in bone.
Yin T, Li L. J Clin Invest.2006;116:1195-1201.
Normal stem cells and cancer stem cells: the niche matters.
Li L, Neaves WB. Cancer Res.2006;66:4553-4557.
Recent advances in understanding extrinsic control of hematopoietic stem cell fate.
Ross J, Li L. Curr Opin Hematol.2006;13:237-242.
Understanding hematopoietic stem-cell microenvironments.
Li Z, Li L. Trends Biochem Sci.2006;31:589-595.
Stem cell niche: structure and function.
Li L, Xie T. Annu Rev Cell Dev Biol.2005;21:605-631.
Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior.
He XC, Zhang J, Li L. Ann N Y Acad Sci.2005;1049:28-38.
BMP signaling and stem cell regulation.
Zhang J, Li L. Dev Biol.2005;284:1-11.
