A six-amino-acid motif is a major determinant in functional evolution of HOX1 proteins

Singh NP, De Kumar B, Paulson A, Parrish ME, Zhang Y, Florens L, Conaway JW, Si K, Krumlauf R. Genes Dev. 2020;34:1680-1696.

 

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila.

Hervas R, Rau MJ, Park Y, Zhang W, Murzin AG, Fitzpatrick JAJ, Scheres SHW, Si K. Science. 2020;367:1230-1234.

 

Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo

Nil Z, Millan RH, Gerbich T, Leal P, Yu Z, Saraf A, Sardiu M, Lange JJ, Yi K, Unruh J, Slaughter B, Si K. Cell. 2019;178:1403-1420 e1421.

 

Antimicrobial peptides modulate long-term memory

Barajas-Azpeleta R, Wu J, Gill J, Welte R, Seidel C, McKinney S, Dissel S, Si K. PLoS Genet. 2018;14:e1007440. doi: 1007410.1001371/journal.pgen.1007440.

 

Regulated Intron Removal Integrates Motivational State and Experience.

Gill J, Park Y, McGinnis JP, Perez-Sanchez C, Blanchette M, Si K. Cell. 2017; 169(5):836-848.e15.

 

Immediate perception of a reward is distinct from the reward's long-term salience.

McGinnis JP, Jiang H, Agha MA, Sanchez CP, Lange J, Yu Z, Marion-Poll F, Si K.eLife. 2016; 5.

A Putative Biochemical Engram of Long-Term Memory.

Li L, Sanchez CP, Slaughter BD, Zhao Y, Khan MR, Unruh JR, Rubinstein B, Si K. Current biology : CB. 2016; 26(23):3143-3156. NIHMSID: NIHMS827720

 

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.

Hervás R, Li L, Majumdar A, Fernández-Ramírez Mdel C, Unruh JR, Slaughter BD, Galera-Prat A, Santana E, Suzuki M, Nagai Y, Bruix M, Casas-Tintó S, Menéndez M, Laurents DV, Si K, Carrión-Vázquez M.

 

Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator.

Khan MR, Li L, Perez-Sanchez C, Saraf A, Florens L, Slaughter BD, Unruh JR, Si K. Cell. 2015;163:1468-1483.

 

Contribution of Orb2A Stability in Regulated Amyloid-Like Oligomerization of Drosophila Orb2.

White-Grindley E, Li L, Mohammad Khan R, Ren F, Saraf A, Florens L, Si K. PLoS Biol. 2014;12:e1001786.

 

Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory.

Majumdar A, Cesario WC, White-Grindley E, Jiang H, Ren F, Khan MR, Li L, Choi EM, Kannan K, Guo F, Unruh J, Slaughter B, Si K. Cell. 2012;148:515-529.

 

Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover.

Mastushita-Sakai T, White-Grindley E, Samuelson J, Seidel C, Si K. Proc Natl Acad Sci U S A. 2010;107:11987-11992.

 

Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.

Si K, Choi YB, White-Grindley E, Majumdar A, Kandel ER.  Cell. 2010;140:421-435.

 

Sustained CPEB-dependent local protein synthesis is required to stabilize synaptic growth for persistence of long-term facilitation in Aplysia.

Miniaci MC, Kim JH, Puthanveettil SV, Si K, Zhu H, Kandel ER, Bailey CH. Neuron. 2008 Sep 25;59(6):1024-36. doi: 10.1016/j.neuron.2008.07.036.

 

A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Si K, Giustetto M, Etkin A, Hsu R, Janisiewicz AM, Miniaci MC, Kim JH, Zhu H, Kandel ER. Cell. 2003;115:893-904.

 

A neuronal isoform of the aplysia CPEB has prion-like properties.

Si K, Lindquist S, Kandel ER. Cell. 2003;115:879-891.

 

Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse.

Giustetto M, Hegde AN, Si K, Casadio A, Inokuchi K, Pei W, Kandel ER, Schwartz JH (2003). Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13680-5.

 

Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.

Theis M, Si K, Kandel ER. (2003). Proc Natl Acad Sci U S A. 2003 Aug 5;100(16): 9602-7.

 

Phosphorylation of Mammalian Eukaryotic Translation Initiation Factor 6 and Its Saccharomyces cerevisiae Homologue Tif6p: Evidence that Phosphorylation of Tif6p Regulates Its Nucleocytoplasmic Distribution and Is Required for Yeast Cell Growth.

Basu U, Si K, Deng H, and Maitra U (2003). Mol Cell Biol. 2003 Sep;23(17):6187-99.

 

The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis.

Basu, U., Si, K., Warner, J., and Maitra, U. (2001). Mol Cell Biol. 2001 Mar;21(5):1453-62. (Equal Contribution)

 

The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor.

Si, K., and Maitra, U (1999). Mol Cell Biol. 1999 Feb 19(2):1416-26.

 

Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6.

Si, K., Chaudhuri, J., Chevesich, J., and Maitra, U (1997). Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14285-90.

 

Function of eukaryotic translation initiation factor 1A (eIF1A) (formerly called eIF-4C) in initiation of protein synthesis.

Chaudhuri, J., Si, K., and Maitra,U. (1997). J Biol Chem. 1997 Mar 21;272(12):7883-91.

 

Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).

Si, K., Das, K., and Maitra, U. (1996). J Biol Chem. 1996 Jul 12;271(28):16934-8.

 

Characterization of Vibrio cholerae EIT or typing phage D10.

Chakrabarti, B.K., Si, K., and Chattopadhyay, D.J. (1996) J Gen Virol. 1996 Nov;77: 2881-4. (Work done during undergraduate studies in India).

 

 

 

 

 

Role of CPEB-Family Proteins in Memory

Kausik Si. The Oxford Handbook of Neuronal Protein Synthesis. (2020)

 

Implications of the Orb2 Amyloid Structure in Huntington’s Disease

Hervas R, Murzin AG, Si K. Int J Mol Sci. 2020;21:E6910. doi: 6910.3390/ijms21186910.

 

When mothers leave their mark

Barajas-Azpeleta R, Si K. eLife. 2019;8:e48899. doi: 48810.47554/eLife.48899.

 

Translational Control by Prion-like Proteins

Li L, McGinnis JP, Si K. Trends Cell Biol. 2018;28:494-505.

 

The Role of Functional Prion-Like Proteins in the Persistence of Memory.

Si K, Kandel ER. Cold Spring Harbor perspectives in biology. 2016; 8(4):a021774.

 

RISC-y Memories.

White-Grindley E, Si K (2006). Cell. 2006 Jan 13;124(1): 23-6.

 

The persistence of long-term memory: a molecular approach to self-sustaining changes in learning-induced synaptic growth.

Bailey CH, Kandel ER, Si K.  Neuron. 2004;44:49-57.