Trainor Lab

‍Filling in the phylogenetic gaps: Induction, migration, and differentiation of neural crest cells in a squamate reptile, the veiled chameleon (Chamaeleo calyptratus).
‍Diaz RE Jr, Shylo NA, Roellig D, Bronner M, Trainor PA. (2019) Developmental Dynamics 248(8):709-727

‍The transcriptome of the veiled chameleon (Chamaeleo calyptratus): A resource for studying the evolution and development of vertebrates.
‍Pinto BJ, Card DC, Castoe TA, Diaz RE Jr, Nielsen SV, Trainor PA, Gamble T. (2019) Developmental Dynamics 248(8):702-708

‍The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
‍Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. (2019) Am J Med Genet A 179(5):864-869

‍An integrative view of Lepidosaur cranial anatomy, development and diversification.
‍Diaz, Jr. R.E. and Trainor, P.A. (2019). In: Heads, Jaws and Muscles Anatomical, Functional and Developmental Diversity in Chordate Evolution (Ziermann, Diaz Jr., Diogo eds). Springer.

‍Mouse embryo culture for the study of neural crest cells.
‍Munoz, W. and Trainor, P.A. (2019). In: Neural Crest Cells Methods and Protocols (Schwarz and Wiszniack eds). Methods Mol Biol. 2019;1976:107-119
‍

2018

Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion.
‍Inman K.E., Caiaffa C.D., Melton K.R., Sandell L.L., Achilleos A., Kume T. and Trainor P.A. (2018) Developmental Dynamics 247(12):1286-1296

‍DAPI staining of whole-mount mouse embryos or fetal organs
‍Sandell L, Inman, K and Trainor P. (2018). Cold Spring Harbor Protocols (10):pdb.prot094029

tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis - Cincinnati type.
‍Noack Watt, K.E., Neben, C., Hall, S., Merrill, A.M. and Trainor, P.A. (2018). Human Molecular Genetics 27(15):2628-2643

‍Alterations in RA signaling affect the development of the mouse coronary vasculature.
‍Wang, S., Huang, W., Castillo, H.A., Kane, M.A., Xavier-Neto, J., Trainor, P.A. and Moise, A.R. (2018). Developmental Dynamics 247(8):976-991

‍The Society for Craniofacial Genetics and Developmental Biology 40th Annual Meeting.
‍Gammill, L., Cox, T., Moody, S., Taneyhill, L., Trainor, P.A. and Marcucio, R. (2018). American Journal Medical Genetics A. 176(5):1270-1273

‍Retinoic acid signalling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
‍Wang, S., Yu, J., Jones, J.W., Pierzchalski, K., Kane, M.A., Trainor, P.A., Xavier-Neto, J. and Moise, A.R. (2018). FASEB J 32(7):3765-3781

‍Dynamic sex chromosomes in Old World chameleons (Squamata: Chamaeleonidae).
‍Nielsen, S.V., Banks, J.L., Diaz Jr. R.E., Trainor, P.A. and Gamble, T. (2018). Journal of Evolutionary Biology 31(4):484-490

‍Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.
‍Iulianella, A., Sakai, D., Kurosaka, H. and Trainor, P.A. (2018). Developmental Dynamics 247(1):170-184

‍Developmental biology - more dynamic than ever!
‍Trainor, P.A. (2018). Developmental Dynamics 247(1):8-9

‍Neural crest cells and their application in regenerative medicine.
‍Trainor, P.A. (2018) In: Ten Cate's Oral Histology - Development, Structure and Function. 9th Edition p21-22. (Ed Antonio Nanci) Mosby Elsevier, St. Louis


2017

‍Lifting the veil on reptile embryology: the Veiled Chameleon (Chamaeleo calyptratus) as a model system to study reptilian development.
‍Diaz Jr, R.E., Bertocchini, F., Trainor, P.A. (2017). Methods in Molecular Biology 1650:269-284

‍Rdh10 loss-of-function and perturbed retinoid signalling underlies the etiology of choanal atresia.
‍Kurosaka, H., Wang, Q., Sandell, L.L., Yamashiro, T. and Trainor, P.A. (2017). Human Molecular Genetics 26(7): 1268-1279

‍New insights and changing paradigms in the regulation of vitamin A metabolism in development.
‍Shannon, S., and Moise, A., and Trainor, P.A. (2017). WIRES Developmental Biology wdev.264

‍The Society for Craniofacial Genetics and Developmental Biology 39th Annual Meeting.
‍Fish, J., Albertson, R.C., Harris, M., Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2017). Am J Med Genet A 173(4):985-1006

‍Rare syndromes of the head and face - Mandibulofacial and Acrofacial dysostoses.
‍Terrazas, K., Dixon, J., Trainor, P.A. and Dixon, M.J. (2017). WIRES Developmental Biology wdev.263

‍Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.
‍Amin, M. B., Miura, N., Uddin, M.K.F., Islam, M.J., Yoshida, N., Iseki, S., Kume, T., Trainor, P.A. Saitsu, H. and Aoto, K. (2017). Congenital Anomalies 57(1):24-31


2016

‍Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.
‍Sakai, D. and Trainor, P.A. (2016). Dev Growth Differ 58(7):577-85

‍The roles of RNA Polymerase 1 subunits Polr1c and Polr1d in craniofacial development and the pathogenesis of Treacher Collins syndrome.
‍Noack Watt, K.E., Achilleos, A., Neben, C., Merrill, A.M. and Trainor, P.A. (2016). PLOS Genetics 12(7):e1006187

‍Transcription factor TLX1 Controls Retinoic Acid Signaling to Ensure Spleen Development.
‍Lenti, E., Farinello, D., Yokoyama, K., Penkov, D., Castagnaro, L., Lavorgna. G., Wuputra. K., Sandel, L. L., Butler Tjaden N. E., Bernassola, F., Caridi, N., De Antoni, A., Wagner, M., Kozinc, K., Neiderreither, K., Blasi, F., Pasini, D., Majdic, G., Tonon, G., Trainor, P.A. and Brendolan, A (2016). J Clinical Investigation 126(7):2452-64

‍Developmental Biology: We are all Walking Mutants.
‍Trainor, P.A. (2016). Essays on Developmental Biology (P Wassarman: Ed) Elsevier, New York. Curr Topics Dev Biol 117:523-538

‍A quantitative method for defining high-arched palate using the Tcof1+/- mutant mouse as a model.
‍Conley, Z.R., Hague, M., Kurosaka, H., Dixon, J., Dixon, M.J and Trainor, P.A. (2016). Developmental Biology 415(2):296-305

‍The Society for Craniofacial Genetics and Developmental Biology 38th Annual Meeting.
‍Taneyhill. L., Hoover-Fong, J. Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2016). Am J Med Genet A 170(7):1732-5

Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation.
‍Sakai D., Dixon J., Achilleos, A., Dixon M.J. and Trainor P.A. (2016). Nature Communications 7:10328


2015

‍Mouse Models of Rare Craniofacial Disorders. In: Craniofacial Development (Yang Chai, editor).
‍Achilleos, A. and Trainor, P.A. (2015). Curr Topics Dev Biol 115:411-458. Academic Press, UK

‍Retinoic Acid Activity in Undifferentiated Neural Progenitors is Sufficient to Fulfil its Role in Restricting Fgf8 Expression for Somitogenesis.
‍Cunningham. T.J., Kumar, S., Brade, T., Sandell, L.L., Lewandoski, M., Trainor, P.A., Colas, A., Mercola, M. and Duester, G. (2015). PLOS One 10(9):e0137894

‍The mighty chondrocyte. No bones about it!
‍Purcell, P. and Trainor, P.A. (2015). J. Dental Research 94(12):1625-7

‍Hand/foot splitting and the "re-evolution’ of mesopodial elements during the evolution and radiation of Chameleons.
‍Diaz, R.E. and Trainor, P.A. (2015). BMC Evolutionary Biology 15:184-208

‍Captive care, raising and breeding of the Veiled Chameleon, Chamaeleo calyptratus.
‍Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.prot087718

‍The Veiled Chameleon, Chamaeleo calyptratus Duméril and Duméril 1851: A model for studying reptile bodyplan development and evolution.
‍Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.emo087700

‍Bi-modal strategy of gastrulation in Chameleon and Turtle embryos.
‍Stower, M. Diaz, R.E., White Crother, M. Crother, B. Marco Llorente, A., Trainor, P.A., Srinivas, S. and Bertocchini, F. (2015). Developmental Dynamics 244(9):1144-1157

‍Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.
‍Aoto, K. Sandell, L. L., Butler Tjaden, N.E, Yuen K., Noack Watt. K.E, Black, B. Durnin, M. and Trainor, P.A. (2015). Developmental Biology 402(1):3-16

‍The Society for Craniofacial Genetics and Developmental Biology 37th Annual Meeting.
‍Richtsmeier, J., Jones, M., Lozanoff, S. and Trainor, P.A. (2015). Am J Med Genet A 167(7):1455-1473

‍Facing up to the challenges of advancing Craniofacial Research.
‍Trainor, P.A. and Richtsmeier, J. (2015).  Am J Med Genet A 167(7):1451-1454

‍Acrofacial dysostosis, Cincinnati type; a mandibulofacial dysostosis syndrome with limb anomalies caused by POLR1A dysfunction.
‍Weaver, K.N., Noack Watt, K.E., Hufnagel, R.B., Sund, K.L., Navajas Acedo, J., Bender, T., Hopkin, R.J., Lohmann, D.R., Trainor, P.A., Wieczorek, D. and Saal, H.M. (2015).  American Journal Human Genetics 96(5):765-74

‍Animal models for studying neural crest development: is the mouse different?
‍Barriga, E.H., Trainor, P.A., Bronner, M. and Mayor, R. (2015). Development 142(9):1555-60

‍Ribosomopathies: Global Process, Tissue Specific Defects.
‍Yelick, P. and Trainor, P.A. (2015). Rare Diseases 3(1):e1025185

‍Cranial nerve development requires co-ordinated Shh and canonical Wnt signalling.
‍Hiroshi Kurosaki, H., Trainor, P.A., Leroux-Berger M. and Iulianella, A. (2015). PLOS One 10(3):e0120821

‍MBTPS/SKI-1/S1P protein convertase is required for ECM signaliing and axial elongation during somitogenesis and vertebral development.
‍Achilleos, A. Huffman, N.T., Seidah, N.G., Trainor, P.A. and Gorski J.P. (2015) Human Molecular Genetics 24(10):2884-98

‍Neural Crest and Placodes
‍Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol Vol 111 Elsevier, New York

‍Neural Crest Cell Evolution: How and when did a Neural Crest Cell become a Neural Crest Cell: In Neural Crest and Placodes
‍Munoz, W.A. and Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:3-26 Elsevier, New York

‍Neural Crest and Placodes – Preface. In: Neural Crest and Placodes
‍Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:xv-xvi . Elsevier, New York

‍Organogenesis Special Issue – Preface.
‍Trainor, P.A. and Johnson, R (2015). Developmental Dynamics 244(3):225-6

‍Co-ordinated brain and craniofacial development depends upon Ptch1/XIAP regulation of cell survival.
‍Aoto, K. and Trainor, P. A. (2015). Human Molecular Genetics 24(3):698-713


2014

‍Development and Evolution of the Pharyngeal Apparatus.
‍Frisdal, A. and Trainor, P.A. (2014). WIRES Developmental Biology wdev.147

‍Leucine-rich Repeat-containing G-protein Coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells during Mouse Embryonic Development.
‍Liu, D., Xi, C.He, Qian, P., Barker, N., Trainor, P.A., Clevers, H., Liu, H. and Li, L. (2014). Journal Biological Chemistry 289(34):23809-16

‍Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalling.
‍Callier, P., Calvel, P., Matevossian, A., Makrythanasis, P., Kurosaka, H., Thauvin-Robinet, C., Bernard, P., Borel, C., Mazaud-Guittot, S., Rolland, A., Guipponi, M., Zimmermann, C., Conne, B., Santoni, F., Vannier, A., Lambert, S., Huet, F., Mugneret, F., Jaruzelska, J., Laurence, F., Wilhelm, D., Jégou, B., Trainor, P.A., Resh, M.D., Antonarakis, S.E. and Nef S. (2014). PLOS Genetics 10(5): e1004340

‍Disrupting  Hh and Wnt signaling interactions promotes cleft lip pathogenesis.
‍Kurosaka, H., Iulianella A., Williams, T. and Trainor P.A. (2014). Journal Clinical Investigation 124(4):1660-1671

‍Embryonic Bauplans and the Developmental Origins of Facial Diversity and Constraint.
‍Young, N. M., Hu, D., Lainoff, A.J., Smith, F., Diaz, R., Tucker A. S., Trainor P.A., Schneider R. S., Hallgrimsson, B. and Marcucio, R (2014) Development 141:1059-1063

‍Neurocristopathies: Disorders of Neural Crest Cell Development.
‍Noack Watt, K. and Trainor P.A. (2014). Neural Crest Cells: Evolution Development and Disease (ed Paul Trainor) Elsevier, New York.

‍Gene transfer techniques in whole embryo cultured post-implantation mouse embryos.
‍Sakai, D and Trainor, P.A. (2014). Methods Mol Biol. 1092:227-34.

‍Cochleovestibular nerve development is integrated with migratory neural crest cells.
‍Sandell, L. L., Tjaden, E. N., Barlow, A and Trainor, P.A. (2014). Developmental Biology 385(2):200–210.


2013

‍Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
‍Lee, R.T.H., Nagai, H., Nakaya, Y., Sheng, G. Trainor, P.A., Weston, J.A. and Thiery, JP (2013). Development 140(24):4890-902.

‍The Retinaldehyde Reductase DHRS3 Is Essential for Preventing Formation of Excess Retinoic Acid During Embryonic Development.
‍Billings, S., Pierzchalski, K., Butler Tjaden, N.E., Pang, X., Trainor, P.A. Kane, M.A. and Moise A.R. (2013) FASEB J. 27(12):4877-89.
‍
‍Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of Syngnathia.
‍Inman, K.E. Kume, T. and Trainor, P.A. (2013). PLoS Genetics 9(12): e1003949.

‍Ribosome Biogenesis in Skeletal Development and the Pathogenesis of Skeletal Disorders.
‍Trainor P.A. and Merrill A.E. (2014). Biochim Biophys Acta.

‍Facial Dysostoses: Etiology, Pathogenesis and Management.
‍Trainor P.A. and Andrews B.T (2013). Am J Med Genet C Semin Med Genet. 163(4):283-94.

‍HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
‍Takeda, S., Liu, H., Sasagawa, S., Dong, Y., Trainor, P.A., Cheng, E, H-Y. and Hsieh, J. J-D. (2013) Journal Clinical Investigation 123(7):3154–3165.

‍The Developmental Etiology and Pathogenesis of Hirschsprung Disease.
‍Butler, N. E. and Trainor, P.A. (2013). Translational Research 162 (1):1–15.

‍Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
‍Wynn, M.L., Rupp, P., Trainor, P.A., Schnell, S. and Kulesa, P.M. (2013). Physical Biology 10(3):035003.

‍Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.
‍Cunningham. T.J., Zhao, X., Sandell, L.L., Evans, S.M., Trainor, P.A. and Duester, G. (2013). Cell Reports 3(5):1503-11.

‍Molecular blueprint for craniofacial morphogenesis and development.
‍Trainor, P.A. (2013). In: Stem cells in craniofacial development, regeneration and repair (Huang and Thesleff eds). Wiley-Blackwell John Wiley & Sons.

‍Signals and switches in Mammalian neural crest cell differentiation.
‍Bhatt, S., Diaz, R. and Trainor, P.A. (2013). Cold Spring Harb Perspect Biol. 5(2).

‍Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis.
‍Barlow, A., Dixon, J., Dixon, M. and Trainor, P.A. (2013). Human Molecular Genetics 22(6):1206-17.


2012

‍Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-Induced Gene Expression during Neuronal Differentiation.
‍Yasukawa, T., Bhatt, S., Takeuchi, T., Kawauchi, J., Takahashi, H., Tsutusi, A., Muraoka, T., Inoue, M., Tsuda, A., Kitajima, S., Conaway, R.C., Conaway, J.W. Trainor, P.A., and Aso, T (2012). Cell Reports 2(5):1129-36.

‍Gadd45g and Map3k4 interactions regulate mouse testis determination via p38-mediated control of Sry expression.
‍Warr, N., Carre, G.-A., Siggers, P., Vitos, J., Brixey, R., Pope, M., Bogani, D., Childers, M., Wells, S., Scudamore, C., Nebreda, A.R., Trainor, P.A. and Greenfield, A. (2012). Developmental Cell 23(5):1020-31.

‍Wholemount nuclear fluorescent imaging: Convenient documentation of embryo morphology.
‍Sandell, L. L, Kurosaka, H. and Trainor, P.A. (2012). Genesis 50(11):844-50.

‍Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe craniofacial defects consistent with acrania-holoprosencephaly-agnathia.
‍Dennis, J.F., Kurosaka, H., Iulianella, A., Pace, J., Thomas, N., Beckham, S., Williams, T. and Trainor, P.A. (2012). PLOS Genetics 8(10):e1002927.

‍Neural crest stem cells: Discovery, properties and potential for therapy.
‍Achilleos, A., Trainor, P.A. (2012). Cell Research 22(2):288.304.

‍Balancing neural crest cell intrinsic processes with those of the microenvironment enable complete enteric nervous system formation.
‍Barlow, A.J., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). Human Molecular Genetics. 21(8):1782-1793.

‍RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse Embryogenesis.
‍Sandell, L.L., Lynn, M.L., Inman, K.E., McDowell, W., Trainor, P.A. (2012). PLoS ONE. 7(2):e30698.

‍Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells.
‍Sakai, D., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). PLoS Genetics. 8(3):e1002566.


2011

‍RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.
‍Farjo, K.M., Moiseyev, G., Nikolaeva, O., Sandell, L.L., Trainor, P.A. and Ma J-X. (2011). Developmental Biology. 357(2):347-355.

‍Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models.
‍Kumar, S., Sandell, L.L., Trainor, P.A., Koentgen, F. and Duester, G. (2012). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821(1):198-205.

‍Flexibility of Neural Stem Cells.
‍Remboutsika, E., Elkouris M., Iulianella A., Andoniadou, C., Poulou, M., Mitsiadis, T.A., Trainor, P.A. and Lovell-Badge, R. (2011). Frontiers in Physiology 2:16.

‍The FaceBase Consortium: A Comprehensive Program to Facilitate Craniofacial Research.
‍Hochheiser, H, Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita, M.L., Murray, J.C., Murray, S., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M. and Trainor, P.A. (2011). Developmental Biology 355 (2):175-182.

‍Rdh10 Mutants Deficient in Limb Bud Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing.
‍Cunningham, T.J., Chatzi, C., Sandell, L.L., Trainor, P.A., and Duester, G. (2011). Developmental Dynamics 240(5):1142-1150.

‍A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.
‍Sandell, L.L., Iulianella, A., Melton, K. Lynn, M., Walker, Inman, K., Bhatt S, Leroux-Berger, M., Crawford, M., Jones, N., Dennis., J., Trainor, P.A. (2011). Genesis 49(4):342-359.

‍Electroporation of Chick and Mouse Embryos.
‍Crull, K. E., Su, F., Swartz, M., Eberhart, J., McLennan, R., Chen, Y. and Trainor, P.A. (2011). Imaging in Developmental Biology: A Laboratory Manual. (Sharpe, Wong, Yuste eds). CSHL Press, New York.


2010

‍Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.
‍Trainor, P.A. (2010). Am J Med Genet A. 152A(12):2984-94.

‍Cardiac Neural crest Cells.
‍Inman, K.E., Ezin, M, Bronner-Fraser, M. and Trainor, P.A. (2010). Heart Development and Regeneration Volume 1:417-434. (Rosenthal and Harvey, eds), Elsevier.

‍Dynamic imaging of mammalian neural tube closure.
‍Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. (2010). Developmental Biology 344(2):941-947.


2009

‍Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
‍Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. (2009) Development 136(14):2329-2334.

‍Interfering with Wnt signalling alters the periodicity of the segmentation clock.
‍Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. (2009) Developmental Biology 330(1):21-31.

‍Treacher Collins syndrome: Unmasking the role of Tcof1/treacle.
‍Sakai D, Trainor PA. (2009). Int J Biochem Cell Biol. 41(6):1229-1232.

‍Treacher Collins syndrome: etiology, pathogenesis and prevention.
‍Trainor PA, Dixon J, Dixon MJ. (2009). European J Human Genetics 17:275-283.


2008

‍Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis.
‍Bogni S, Trainor P, Natarajan D, Krumlauf R, Pachnis V. (2008) Development. 135(18):3007-3011.

‍Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
‍Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA. (2008) Nature Medicine 14(2):125-133.
‍Comments about the paper may be found in Nat Med. 2008 Feb;14(2):115-6.

‍Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.
‍Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA. (2008) Development 135(4):729-741.


2007

‍RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
‍Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. (2007) Genes and Development 21(9):1113-1124.


2006

‍Neural Crest Stem and Progenitor Cells.
‍Crane JF, Trainor PA. (2006) Annual Rev Cell Dev Biol. 22:267-286.

‍Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.
‍Dixon J, Jones NC, Sandell LL, Jayasinghe SM, Crane J, Rey JP, Dixon MJ, Trainor PA. (2006) Proc Natl Acad Sci 103(36)13403-13408.

‍Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
‍Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O. (2006) Developmental Cell 10(3):355-366.


2005

‍Relations and interactions between cranial mesoderm and neural crest populations.
‍Noden DM, Trainor PA. (2005) J Anatomy 207(5):575-601.


2004

‍Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.
‍Kulesa P, Ellies DL, Trainor PA. (2004) Developmental Dynamics 229(1):14-29.


2003

‍Somitogenesis: breaking new boundaries.
‍Iulianella A, Melton KR, Trainor PA. (2003) Neuron 40(1):11-14.

‍Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia.
‍Iulianella A, Vanden Heuvel G, Trainor PA. (2003) Gene Expr Patterns 3(5):571-577.

‍Development. The bills of qucks and duails.
‍Trainor, PA. (2003) Science 299(5606):523-524.


2002

‍Riding the crest of Wnt signaling.
‍Trainor PA, Krumlauf R. (2002) Science 297(5582):781-783.

‍Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
‍Trainor PA, Ariza-McNaughton L, Krumlauf R. (2002) Science 295(5558):1288-1291.
‍Comments about this paper may be found in Nature Reviews Neuroscience 3:254
‍Additional  comments about this paper may be found in Nature 416: 493-494.

‍Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.
‍Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R. (2002) Development 129(2):433-442.


2001

‍Hox genes, neural crest cells and branchial arch patterning.
‍Trainor PA and Krumlauf R. (2001). Curr Opin Cell Biol 13(6):698-705

‍Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest.
‍Gavalas A, Trainor PA, Ariza-McNaughton L, Krumlauf R. (2001) Development 128(15):3017-3027.


2000

‍Patterning cranial neural crest: roles for hindbrain segmentation and plasticity of Hox gene expression.
‍Trainor PA, Krumlauf R. (2000) Nature Rev Neurosci. 1(2):116-124.

‍Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head.
‍Manzanares M, Wada H, Itasaki N, Trainor PA, Krumlauf R, Holland PW. (2000) Nature 408(6814):854-857.

‍Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.
‍Manzanares M, Trainor PA, Ariza-McNaughton L, Nonchev S, Krumlauf R. (2000) Mech Dev. 94(1-2):147-156.

‍Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.
‍Golding JP, Trainor PA, Krumlauf R, Gassmann M. (2000) Nature Cell Biology 2(2):103-109.

‍Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
‍Trainor PA, Krumlauf R. (2000) Nature Cell Biology 2(2):96-102

‍Filling in the phylogenetic gaps: Induction, migration, and differentiation of neural crest cells in a squamate reptile, the veiled chameleon (Chamaeleo calyptratus).
‍Diaz RE Jr, Shylo NA, Roellig D, Bronner M, Trainor PA. (2019) Developmental Dynamics 248(8):709-727

‍The transcriptome of the veiled chameleon (Chamaeleo calyptratus): A resource for studying the evolution and development of vertebrates.
‍Pinto BJ, Card DC, Castoe TA, Diaz RE Jr, Nielsen SV, Trainor PA, Gamble T. (2019) Developmental Dynamics 248(8):702-708

‍The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
‍Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. (2019) Am J Med Genet A 179(5):864-869

‍An integrative view of Lepidosaur cranial anatomy, development and diversification.
‍Diaz, Jr. R.E. and Trainor, P.A. (2019). In: Heads, Jaws and Muscles Anatomical, Functional and Developmental Diversity in Chordate Evolution (Ziermann, Diaz Jr., Diogo eds). Springer.

‍Mouse embryo culture for the study of neural crest cells.
‍Munoz, W. and Trainor, P.A. (2019). In: Neural Crest Cells Methods and Protocols (Schwarz and Wiszniack eds). Methods Mol Biol. 2019;1976:107-119
‍

2018

Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion.
‍Inman K.E., Caiaffa C.D., Melton K.R., Sandell L.L., Achilleos A., Kume T. and Trainor P.A. (2018) Developmental Dynamics 247(12):1286-1296

‍DAPI staining of whole-mount mouse embryos or fetal organs
‍Sandell L, Inman, K and Trainor P. (2018). Cold Spring Harbor Protocols (10):pdb.prot094029

tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis - Cincinnati type.
‍Noack Watt, K.E., Neben, C., Hall, S., Merrill, A.M. and Trainor, P.A. (2018). Human Molecular Genetics 27(15):2628-2643

‍Alterations in RA signaling affect the development of the mouse coronary vasculature.
‍Wang, S., Huang, W., Castillo, H.A., Kane, M.A., Xavier-Neto, J., Trainor, P.A. and Moise, A.R. (2018). Developmental Dynamics 247(8):976-991

‍The Society for Craniofacial Genetics and Developmental Biology 40th Annual Meeting.
‍Gammill, L., Cox, T., Moody, S., Taneyhill, L., Trainor, P.A. and Marcucio, R. (2018). American Journal Medical Genetics A. 176(5):1270-1273

‍Retinoic acid signalling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
‍Wang, S., Yu, J., Jones, J.W., Pierzchalski, K., Kane, M.A., Trainor, P.A., Xavier-Neto, J. and Moise, A.R. (2018). FASEB J 32(7):3765-3781

‍Dynamic sex chromosomes in Old World chameleons (Squamata: Chamaeleonidae).
‍Nielsen, S.V., Banks, J.L., Diaz Jr. R.E., Trainor, P.A. and Gamble, T. (2018). Journal of Evolutionary Biology 31(4):484-490

‍Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.
‍Iulianella, A., Sakai, D., Kurosaka, H. and Trainor, P.A. (2018). Developmental Dynamics 247(1):170-184

‍Developmental biology - more dynamic than ever!
‍Trainor, P.A. (2018). Developmental Dynamics 247(1):8-9

‍Neural crest cells and their application in regenerative medicine.
‍Trainor, P.A. (2018) In: Ten Cate's Oral Histology - Development, Structure and Function. 9th Edition p21-22. (Ed Antonio Nanci) Mosby Elsevier, St. Louis


2017

‍Lifting the veil on reptile embryology: the Veiled Chameleon (Chamaeleo calyptratus) as a model system to study reptilian development.
‍Diaz Jr, R.E., Bertocchini, F., Trainor, P.A. (2017). Methods in Molecular Biology 1650:269-284

‍Rdh10 loss-of-function and perturbed retinoid signalling underlies the etiology of choanal atresia.
‍Kurosaka, H., Wang, Q., Sandell, L.L., Yamashiro, T. and Trainor, P.A. (2017). Human Molecular Genetics 26(7): 1268-1279

‍New insights and changing paradigms in the regulation of vitamin A metabolism in development.
‍Shannon, S., and Moise, A., and Trainor, P.A. (2017). WIRES Developmental Biology wdev.264

‍The Society for Craniofacial Genetics and Developmental Biology 39th Annual Meeting.
‍Fish, J., Albertson, R.C., Harris, M., Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2017). Am J Med Genet A 173(4):985-1006

‍Rare syndromes of the head and face - Mandibulofacial and Acrofacial dysostoses.
‍Terrazas, K., Dixon, J., Trainor, P.A. and Dixon, M.J. (2017). WIRES Developmental Biology wdev.263

‍Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.
‍Amin, M. B., Miura, N., Uddin, M.K.F., Islam, M.J., Yoshida, N., Iseki, S., Kume, T., Trainor, P.A. Saitsu, H. and Aoto, K. (2017). Congenital Anomalies 57(1):24-31


2016

‍Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.
‍Sakai, D. and Trainor, P.A. (2016). Dev Growth Differ 58(7):577-85

‍The roles of RNA Polymerase 1 subunits Polr1c and Polr1d in craniofacial development and the pathogenesis of Treacher Collins syndrome.
‍Noack Watt, K.E., Achilleos, A., Neben, C., Merrill, A.M. and Trainor, P.A. (2016). PLOS Genetics 12(7):e1006187

‍Transcription factor TLX1 Controls Retinoic Acid Signaling to Ensure Spleen Development.
‍Lenti, E., Farinello, D., Yokoyama, K., Penkov, D., Castagnaro, L., Lavorgna. G., Wuputra. K., Sandel, L. L., Butler Tjaden N. E., Bernassola, F., Caridi, N., De Antoni, A., Wagner, M., Kozinc, K., Neiderreither, K., Blasi, F., Pasini, D., Majdic, G., Tonon, G., Trainor, P.A. and Brendolan, A (2016). J Clinical Investigation 126(7):2452-64

‍Developmental Biology: We are all Walking Mutants.
‍Trainor, P.A. (2016). Essays on Developmental Biology (P Wassarman: Ed) Elsevier, New York. Curr Topics Dev Biol 117:523-538

‍A quantitative method for defining high-arched palate using the Tcof1+/- mutant mouse as a model.
‍Conley, Z.R., Hague, M., Kurosaka, H., Dixon, J., Dixon, M.J and Trainor, P.A. (2016). Developmental Biology 415(2):296-305

‍The Society for Craniofacial Genetics and Developmental Biology 38th Annual Meeting.
‍Taneyhill. L., Hoover-Fong, J. Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2016). Am J Med Genet A 170(7):1732-5

Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation.
‍Sakai D., Dixon J., Achilleos, A., Dixon M.J. and Trainor P.A. (2016). Nature Communications 7:10328


2015

‍Mouse Models of Rare Craniofacial Disorders. In: Craniofacial Development (Yang Chai, editor).
‍Achilleos, A. and Trainor, P.A. (2015). Curr Topics Dev Biol 115:411-458. Academic Press, UK

‍Retinoic Acid Activity in Undifferentiated Neural Progenitors is Sufficient to Fulfil its Role in Restricting Fgf8 Expression for Somitogenesis.
‍Cunningham. T.J., Kumar, S., Brade, T., Sandell, L.L., Lewandoski, M., Trainor, P.A., Colas, A., Mercola, M. and Duester, G. (2015). PLOS One 10(9):e0137894

‍The mighty chondrocyte. No bones about it!
‍Purcell, P. and Trainor, P.A. (2015). J. Dental Research 94(12):1625-7

‍Hand/foot splitting and the "re-evolution’ of mesopodial elements during the evolution and radiation of Chameleons.
‍Diaz, R.E. and Trainor, P.A. (2015). BMC Evolutionary Biology 15:184-208

‍Captive care, raising and breeding of the Veiled Chameleon, Chamaeleo calyptratus.
‍Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.prot087718

‍The Veiled Chameleon, Chamaeleo calyptratus Duméril and Duméril 1851: A model for studying reptile bodyplan development and evolution.
‍Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.emo087700

‍Bi-modal strategy of gastrulation in Chameleon and Turtle embryos.
‍Stower, M. Diaz, R.E., White Crother, M. Crother, B. Marco Llorente, A., Trainor, P.A., Srinivas, S. and Bertocchini, F. (2015). Developmental Dynamics 244(9):1144-1157

‍Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.
‍Aoto, K. Sandell, L. L., Butler Tjaden, N.E, Yuen K., Noack Watt. K.E, Black, B. Durnin, M. and Trainor, P.A. (2015). Developmental Biology 402(1):3-16

‍The Society for Craniofacial Genetics and Developmental Biology 37th Annual Meeting.
‍Richtsmeier, J., Jones, M., Lozanoff, S. and Trainor, P.A. (2015). Am J Med Genet A 167(7):1455-1473

‍Facing up to the challenges of advancing Craniofacial Research.
‍Trainor, P.A. and Richtsmeier, J. (2015).  Am J Med Genet A 167(7):1451-1454

‍Acrofacial dysostosis, Cincinnati type; a mandibulofacial dysostosis syndrome with limb anomalies caused by POLR1A dysfunction.
‍Weaver, K.N., Noack Watt, K.E., Hufnagel, R.B., Sund, K.L., Navajas Acedo, J., Bender, T., Hopkin, R.J., Lohmann, D.R., Trainor, P.A., Wieczorek, D. and Saal, H.M. (2015).  American Journal Human Genetics 96(5):765-74

‍Animal models for studying neural crest development: is the mouse different?
‍Barriga, E.H., Trainor, P.A., Bronner, M. and Mayor, R. (2015). Development 142(9):1555-60

‍Ribosomopathies: Global Process, Tissue Specific Defects.
‍Yelick, P. and Trainor, P.A. (2015). Rare Diseases 3(1):e1025185

‍Cranial nerve development requires co-ordinated Shh and canonical Wnt signalling.
‍Hiroshi Kurosaki, H., Trainor, P.A., Leroux-Berger M. and Iulianella, A. (2015). PLOS One 10(3):e0120821

‍MBTPS/SKI-1/S1P protein convertase is required for ECM signaliing and axial elongation during somitogenesis and vertebral development.
‍Achilleos, A. Huffman, N.T., Seidah, N.G., Trainor, P.A. and Gorski J.P. (2015) Human Molecular Genetics 24(10):2884-98

‍Neural Crest and Placodes
‍Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol Vol 111 Elsevier, New York

‍Neural Crest Cell Evolution: How and when did a Neural Crest Cell become a Neural Crest Cell: In Neural Crest and Placodes
‍Munoz, W.A. and Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:3-26 Elsevier, New York

‍Neural Crest and Placodes – Preface. In: Neural Crest and Placodes
‍Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:xv-xvi . Elsevier, New York

‍Organogenesis Special Issue – Preface.
‍Trainor, P.A. and Johnson, R (2015). Developmental Dynamics 244(3):225-6

‍Co-ordinated brain and craniofacial development depends upon Ptch1/XIAP regulation of cell survival.
‍Aoto, K. and Trainor, P. A. (2015). Human Molecular Genetics 24(3):698-713


2014

‍Development and Evolution of the Pharyngeal Apparatus.
‍Frisdal, A. and Trainor, P.A. (2014). WIRES Developmental Biology wdev.147

‍Leucine-rich Repeat-containing G-protein Coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells during Mouse Embryonic Development.
‍Liu, D., Xi, C.He, Qian, P., Barker, N., Trainor, P.A., Clevers, H., Liu, H. and Li, L. (2014). Journal Biological Chemistry 289(34):23809-16

‍Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalling.
‍Callier, P., Calvel, P., Matevossian, A., Makrythanasis, P., Kurosaka, H., Thauvin-Robinet, C., Bernard, P., Borel, C., Mazaud-Guittot, S., Rolland, A., Guipponi, M., Zimmermann, C., Conne, B., Santoni, F., Vannier, A., Lambert, S., Huet, F., Mugneret, F., Jaruzelska, J., Laurence, F., Wilhelm, D., Jégou, B., Trainor, P.A., Resh, M.D., Antonarakis, S.E. and Nef S. (2014). PLOS Genetics 10(5): e1004340

‍Disrupting  Hh and Wnt signaling interactions promotes cleft lip pathogenesis.
‍Kurosaka, H., Iulianella A., Williams, T. and Trainor P.A. (2014). Journal Clinical Investigation 124(4):1660-1671

‍Embryonic Bauplans and the Developmental Origins of Facial Diversity and Constraint.
‍Young, N. M., Hu, D., Lainoff, A.J., Smith, F., Diaz, R., Tucker A. S., Trainor P.A., Schneider R. S., Hallgrimsson, B. and Marcucio, R (2014) Development 141:1059-1063

‍Neurocristopathies: Disorders of Neural Crest Cell Development.
‍Noack Watt, K. and Trainor P.A. (2014). Neural Crest Cells: Evolution Development and Disease (ed Paul Trainor) Elsevier, New York.

‍Gene transfer techniques in whole embryo cultured post-implantation mouse embryos.
‍Sakai, D and Trainor, P.A. (2014). Methods Mol Biol. 1092:227-34.

‍Cochleovestibular nerve development is integrated with migratory neural crest cells.
‍Sandell, L. L., Tjaden, E. N., Barlow, A and Trainor, P.A. (2014). Developmental Biology 385(2):200–210.


2013

‍Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
‍Lee, R.T.H., Nagai, H., Nakaya, Y., Sheng, G. Trainor, P.A., Weston, J.A. and Thiery, JP (2013). Development 140(24):4890-902.

‍The Retinaldehyde Reductase DHRS3 Is Essential for Preventing Formation of Excess Retinoic Acid During Embryonic Development.
‍Billings, S., Pierzchalski, K., Butler Tjaden, N.E., Pang, X., Trainor, P.A. Kane, M.A. and Moise A.R. (2013) FASEB J. 27(12):4877-89.
‍
‍Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of Syngnathia.
‍Inman, K.E. Kume, T. and Trainor, P.A. (2013). PLoS Genetics 9(12): e1003949.

‍Ribosome Biogenesis in Skeletal Development and the Pathogenesis of Skeletal Disorders.
‍Trainor P.A. and Merrill A.E. (2014). Biochim Biophys Acta.

‍Facial Dysostoses: Etiology, Pathogenesis and Management.
‍Trainor P.A. and Andrews B.T (2013). Am J Med Genet C Semin Med Genet. 163(4):283-94.

‍HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
‍Takeda, S., Liu, H., Sasagawa, S., Dong, Y., Trainor, P.A., Cheng, E, H-Y. and Hsieh, J. J-D. (2013) Journal Clinical Investigation 123(7):3154–3165.

‍The Developmental Etiology and Pathogenesis of Hirschsprung Disease.
‍Butler, N. E. and Trainor, P.A. (2013). Translational Research 162 (1):1–15.

‍Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
‍Wynn, M.L., Rupp, P., Trainor, P.A., Schnell, S. and Kulesa, P.M. (2013). Physical Biology 10(3):035003.

‍Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.
‍Cunningham. T.J., Zhao, X., Sandell, L.L., Evans, S.M., Trainor, P.A. and Duester, G. (2013). Cell Reports 3(5):1503-11.

‍Molecular blueprint for craniofacial morphogenesis and development.
‍Trainor, P.A. (2013). In: Stem cells in craniofacial development, regeneration and repair (Huang and Thesleff eds). Wiley-Blackwell John Wiley & Sons.

‍Signals and switches in Mammalian neural crest cell differentiation.
‍Bhatt, S., Diaz, R. and Trainor, P.A. (2013). Cold Spring Harb Perspect Biol. 5(2).

‍Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis.
‍Barlow, A., Dixon, J., Dixon, M. and Trainor, P.A. (2013). Human Molecular Genetics 22(6):1206-17.


2012

‍Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-Induced Gene Expression during Neuronal Differentiation.
‍Yasukawa, T., Bhatt, S., Takeuchi, T., Kawauchi, J., Takahashi, H., Tsutusi, A., Muraoka, T., Inoue, M., Tsuda, A., Kitajima, S., Conaway, R.C., Conaway, J.W. Trainor, P.A., and Aso, T (2012). Cell Reports 2(5):1129-36.

‍Gadd45g and Map3k4 interactions regulate mouse testis determination via p38-mediated control of Sry expression.
‍Warr, N., Carre, G.-A., Siggers, P., Vitos, J., Brixey, R., Pope, M., Bogani, D., Childers, M., Wells, S., Scudamore, C., Nebreda, A.R., Trainor, P.A. and Greenfield, A. (2012). Developmental Cell 23(5):1020-31.

‍Wholemount nuclear fluorescent imaging: Convenient documentation of embryo morphology.
‍Sandell, L. L, Kurosaka, H. and Trainor, P.A. (2012). Genesis 50(11):844-50.

‍Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe craniofacial defects consistent with acrania-holoprosencephaly-agnathia.
‍Dennis, J.F., Kurosaka, H., Iulianella, A., Pace, J., Thomas, N., Beckham, S., Williams, T. and Trainor, P.A. (2012). PLOS Genetics 8(10):e1002927.

‍Neural crest stem cells: Discovery, properties and potential for therapy.
‍Achilleos, A., Trainor, P.A. (2012). Cell Research 22(2):288.304.

‍Balancing neural crest cell intrinsic processes with those of the microenvironment enable complete enteric nervous system formation.
‍Barlow, A.J., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). Human Molecular Genetics. 21(8):1782-1793.

‍RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse Embryogenesis.
‍Sandell, L.L., Lynn, M.L., Inman, K.E., McDowell, W., Trainor, P.A. (2012). PLoS ONE. 7(2):e30698.

‍Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells.
‍Sakai, D., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). PLoS Genetics. 8(3):e1002566.


2011

‍RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.
‍Farjo, K.M., Moiseyev, G., Nikolaeva, O., Sandell, L.L., Trainor, P.A. and Ma J-X. (2011). Developmental Biology. 357(2):347-355.

‍Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models.
‍Kumar, S., Sandell, L.L., Trainor, P.A., Koentgen, F. and Duester, G. (2012). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821(1):198-205.

‍Flexibility of Neural Stem Cells.
‍Remboutsika, E., Elkouris M., Iulianella A., Andoniadou, C., Poulou, M., Mitsiadis, T.A., Trainor, P.A. and Lovell-Badge, R. (2011). Frontiers in Physiology 2:16.

‍The FaceBase Consortium: A Comprehensive Program to Facilitate Craniofacial Research.
‍Hochheiser, H, Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita, M.L., Murray, J.C., Murray, S., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M. and Trainor, P.A. (2011). Developmental Biology 355 (2):175-182.

‍Rdh10 Mutants Deficient in Limb Bud Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing.
‍Cunningham, T.J., Chatzi, C., Sandell, L.L., Trainor, P.A., and Duester, G. (2011). Developmental Dynamics 240(5):1142-1150.

‍A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.
‍Sandell, L.L., Iulianella, A., Melton, K. Lynn, M., Walker, Inman, K., Bhatt S, Leroux-Berger, M., Crawford, M., Jones, N., Dennis., J., Trainor, P.A. (2011). Genesis 49(4):342-359.

‍Electroporation of Chick and Mouse Embryos.
‍Crull, K. E., Su, F., Swartz, M., Eberhart, J., McLennan, R., Chen, Y. and Trainor, P.A. (2011). Imaging in Developmental Biology: A Laboratory Manual. (Sharpe, Wong, Yuste eds). CSHL Press, New York.


2010

‍Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.
‍Trainor, P.A. (2010). Am J Med Genet A. 152A(12):2984-94.

‍Cardiac Neural crest Cells.
‍Inman, K.E., Ezin, M, Bronner-Fraser, M. and Trainor, P.A. (2010). Heart Development and Regeneration Volume 1:417-434. (Rosenthal and Harvey, eds), Elsevier.

‍Dynamic imaging of mammalian neural tube closure.
‍Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. (2010). Developmental Biology 344(2):941-947.


2009

‍Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
‍Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. (2009) Development 136(14):2329-2334.

‍Interfering with Wnt signalling alters the periodicity of the segmentation clock.
‍Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. (2009) Developmental Biology 330(1):21-31.

‍Treacher Collins syndrome: Unmasking the role of Tcof1/treacle.
‍Sakai D, Trainor PA. (2009). Int J Biochem Cell Biol. 41(6):1229-1232.

‍Treacher Collins syndrome: etiology, pathogenesis and prevention.
‍Trainor PA, Dixon J, Dixon MJ. (2009). European J Human Genetics 17:275-283.


2008

‍Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis.
‍Bogni S, Trainor P, Natarajan D, Krumlauf R, Pachnis V. (2008) Development. 135(18):3007-3011.

‍Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
‍Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA. (2008) Nature Medicine 14(2):125-133.
‍Comments about the paper may be found in Nat Med. 2008 Feb;14(2):115-6.

‍Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.
‍Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA. (2008) Development 135(4):729-741.


2007

‍RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
‍Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. (2007) Genes and Development 21(9):1113-1124.


2006

‍Neural Crest Stem and Progenitor Cells.
‍Crane JF, Trainor PA. (2006) Annual Rev Cell Dev Biol. 22:267-286.

‍Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.
‍Dixon J, Jones NC, Sandell LL, Jayasinghe SM, Crane J, Rey JP, Dixon MJ, Trainor PA. (2006) Proc Natl Acad Sci 103(36)13403-13408.

‍Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
‍Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O. (2006) Developmental Cell 10(3):355-366.


2005

‍Relations and interactions between cranial mesoderm and neural crest populations.
‍Noden DM, Trainor PA. (2005) J Anatomy 207(5):575-601.


2004

‍Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.
‍Kulesa P, Ellies DL, Trainor PA. (2004) Developmental Dynamics 229(1):14-29.


2003

‍Somitogenesis: breaking new boundaries.
‍Iulianella A, Melton KR, Trainor PA. (2003) Neuron 40(1):11-14.

‍Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia.
‍Iulianella A, Vanden Heuvel G, Trainor PA. (2003) Gene Expr Patterns 3(5):571-577.

‍Development. The bills of qucks and duails.
‍Trainor, PA. (2003) Science 299(5606):523-524.


2002

‍Riding the crest of Wnt signaling.
‍Trainor PA, Krumlauf R. (2002) Science 297(5582):781-783.

‍Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
‍Trainor PA, Ariza-McNaughton L, Krumlauf R. (2002) Science 295(5558):1288-1291.
‍Comments about this paper may be found in Nature Reviews Neuroscience 3:254
‍Additional  comments about this paper may be found in Nature 416: 493-494.

‍Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.
‍Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R. (2002) Development 129(2):433-442.


2001

‍Hox genes, neural crest cells and branchial arch patterning.
‍Trainor PA and Krumlauf R. (2001). Curr Opin Cell Biol 13(6):698-705

‍Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest.
‍Gavalas A, Trainor PA, Ariza-McNaughton L, Krumlauf R. (2001) Development 128(15):3017-3027.


2000

‍Patterning cranial neural crest: roles for hindbrain segmentation and plasticity of Hox gene expression.
‍Trainor PA, Krumlauf R. (2000) Nature Rev Neurosci. 1(2):116-124.

‍Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head.
‍Manzanares M, Wada H, Itasaki N, Trainor PA, Krumlauf R, Holland PW. (2000) Nature 408(6814):854-857.

‍Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.
‍Manzanares M, Trainor PA, Ariza-McNaughton L, Nonchev S, Krumlauf R. (2000) Mech Dev. 94(1-2):147-156.

‍Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.
‍Golding JP, Trainor PA, Krumlauf R, Gassmann M. (2000) Nature Cell Biology 2(2):103-109.

‍Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
‍Trainor PA, Krumlauf R. (2000) Nature Cell Biology 2(2):96-102