Publications

2020

Original Research Papers

Genetic background impacts the timing of synaptonemal complex breakdown in Drosophila melanogaster
Wesley ER, Hawley RS, Billmyre KK.  [published ahead of print October 18 2020]. Chromosoma. 2020.
Original Data

Further identification and characterization of breakpoints and mutations on Drosophila melanogaster balancer chromosomes
Miller DE, Kahsai L, Buddika K, Dixon MJ, Kim BY, Calvi BR, Sokol NS, Hawley RS, Cook KR. [published ahead of print September 26 2020]. G3 (Bethesda). 2020.
Original Data

Regulation of Polo Kinase by Matrimony Is Required for Cohesin Maintenance during Drosophila melanogaster Female Meiosis
Bonner AM, Hughes SE, Hawley RS. Curr Biol. 2020;30:715-722e713.
Original Data

Reviews, Commentaries, Chapters or Books

Alternative Synaptonemal Complex Structures: Too Much of a Good Thing?
Hughes SE, Hawley RS. [published ahead of print August 13 2020]. Trends Genet. 2020.

Meiosis: Location, Location, Location, How Crossovers Ensure Segregation
Hughes, S. E., Hawley, R. S. Curr Biol. 2020 Apr 6;30(7):R311-R313

2019

Original Research Papers

X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance
Billmyre KK, Cahoon CK, Heenan GM, Wesley ER, Yu Z, Unruh JR, Takeo S, Hawley RS. Proc Natl Acad Sci U S A. 2019;116:21641-21650.
Original Data

The E3 ubiquitin ligase SINA regulates the assembly and disassembly of the synaptonemal complex in Drosophila females
Hughes SE, Hemenway E, Guo F, Yi K, Yu Z, Hawley RS. PLoS Genet. 2019;15:e1008161. doi: 10.1371/journal.pgen.1008161.
Original Data

Narya, a RING finger domain-containing protein, is required for both meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster
Lake CM, Nielsen RJ, Bonner AM, Eche S, White-Brown S, McKim KS, Hawley RS. PLoS Genet. 2019;15:e1007886. doi: 1007810.1001371/journal.pgen.1007886.
Original Data

Functional consequences of the evolution of matrimony, a meiosis-specific inhibitor of Polo kinase
Bonner AM, Hawley RS. Mol Biol Evol. 2019;36:69-83.
Original Data

Reviews, Commentaries, Chapters or Books

The Joy of Balancers
Miller DE, Cook KR, Hawley RS. PLoS Genet. 2019;15:e1008421. doi: 1008410.1001371/journal.pgen.1008421.

2018

Original Research Papers

Origin, Composition, and Structure of the Supernumerary B Chromosome of Drosophila melanogaster
Hanlon SL, Miller DE, Eche S, Hawley RS. Genetics. 2018;210:1197-1212.
Original Data

Highly Contiguous Genome Assemblies of 15 Drosophila Species Generated Using Nanopore Sequencing
Miller DE, Staber C, Zeitlinger J, Hawley RS. G3 (Bethesda). 2018;8:3131-3141.
Original Data

Local Inversion Heterozygosity Alters Recombination throughout the Genome
Crown KN, Miller DE, Sekelsky J, Hawley RS. Curr Biol. 2018;28:2984-2990.e2983.
Original Data

Combined expansion microscopy with structured illumination microscopy for analyzing protein complexes
Wang Y, Yu Z, Cahoon CK, Parmely T, Thomas N, Unruh JR, Slaughter BD, Hawley RS. Nat Protoc.2018;13:1869-1895.
Original Data

Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing
Solares EA, Chakraborty M, Miller DE, Kalsow S, Hall K, Perera AG, Emerson JJ, Hawley RS. G3 (Bethesda). 2018;8:3143-3154.
Original Data

The Molecular and Genetic Characterization of Second Chromosome Balancers in Drosophila melanogaster
Miller DE, Cook KR, Hemenway EA, Fang V, Miller AL, Hales KG, Hawley RS. G3 (Bethesda).2018;8:1161-1171.
Original Data

Reviews, Commentaries, Chapters or Books

B chromosomes in the Drosophila genus
Hanlon SL, Hawley RS. Genes (Basel). 2018;9:E470. doi: 410.3390/genes9100470.
Original Data

The anatomy of a nucleus: As revealed by chromosome painting
Slaughter BD, Hawley RS. PLoS Genet.2018;14:e1007445. doi: 10.1371/journal.pgen.1007445.

Female meiosis: synapsis, recombination, and segregation in Drosophila melanogaster
Hughes SE, Miller DE, Miller AL, Hawley RS. Genetics.2018;208:875-908.

2017

Original Research Papers

Superresolution expansion microscopy reveals the three-dimensional organization of the Drosophila synaptonemal complex.
Cahoon CK, Yu Z, Wang Y, Guo F, Unruh JR, Slaughter BD, Hawley RS. Proc Natl Acad Sci U S A.2017;114:E6857-E6866.
Original Data

Reviews, Commentaries, Chapters or Books

Live Imaging of Meiosis I in Late-Stage Drosophila melanogaster Oocytes
Hughes SE, Hawley RS. Methods Mol Biol.2017;1471:255-264.
Original Data

Meiotic Recombination: Taking the Path Less Traveled
Miller DE, Hawley RS. Curr Biol.2017;27:R26-R28.

2016

Original Research Papers

Third Chromosome Balancer Inversions Disrupt Protein-Coding Genes and Influence Distal Recombination Events in Drosophila melanogaster
Miller DE, Cook KR, Arvanitakis AV, Hawley RS. G3 (Bethesda). 2016;6:1959-1967.
Original Data

Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster.
Miller DE, Cook KR, Yeganeh Kazemi N, Smith CB, Cockrell AJ, Hawley RS, Bergman CM. Proc Natl Acad Sci U S A. 2016;113:E1352-E1361.
Original Data

Whole-Genome Analysis of Individual Meiotic Events in Drosophila melanogaster Reveals That Noncrossover Gene Conversions Are Insensitive to Interference and the Centromere Effect
Miller DE, Smith CB, Kazemi NY, Cockrell AJ, Arvanitakas AV, Blumenstiel JP, Jaspersen SL, Hawley RS. Genetics. 2016;203:159-171.
Original Data

Reviews, Commentaries, Chapters or Books

A Nucleoporin at the Meiotic Kinetochore
Bonner AM, Hawley RS. Dev Cell. 2016;38:447-448.​

Meiosis: cohesin are not just for sisters any more
Cahoon CK, Hawley RS. Curr Biol.2016;26:R523-525.

Alfred Sturtevant and George Beadle Untangle Inversions
Hawley RS, Ganetzky B. Genetics. 2016;203:1001-1003.

Regulating the construction and demolition of the synaptonemal complex
Cahoon CK, Hawley RS. Nat Struct Mol Biol. 2016;23:369-377.

Becoming a crossover-competent DSB
Lake CM, Hawley RS. Semin Cell Dev Biol.2016;54:117-125.

The Centenary of GENETICS: Bridges to the Future.
Ganetzky B, Hawley RS. Genetics. 2016;202:15-23.

2015

Original Research Papers

Dynamics of Wolbachia pipientis Gene Expression Across the Drosophila melanogaster Life Cycle.
Gutzwiller F, Carmo CR, Miller DE, Rice DW, Newton IL, Hawley RS, Teixeira L, Bergman CM. G3 (Bethesda). 2015;5:2843-2856.

Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila.
Lake CM, Nielsen RJ, Guo F, Unruh JR, Slaughter BD, Hawley RS. eLife. 2015;4:e08287. doi: 08210.07554/eLife.08287.
Original Data

Reviews, Commentaries, Chapters or Books

Conference Report
Backeljauw PF, Bondy C, Chernausek SD, Cernich JT, Cole DA, Fasciano LP, Foodim J, Hawley S, Hong DS, Knickmeyer RC, Kruszka P, Lin AE, Lippe BM, Lorigan GA, Maslen CL, Mauras N, Page DC, Pemberton VL, Prakash SK, Quigley CA, Ranallo KC, Reiss AL, Sandberg DE, Scurlock C, Silberbach M. Proceedings from the Turner Resource Network symposium: the crossroads of health care research and health care delivery. Am J Med Genet A. 2015;167A:1962-1971.

2014

Original Research Papers

Synaptonemal complex extension from clustered telomeres mediates full-length chromosome pairing in Schmidtea mediterranea.
Xiang Y, Miller DE, Ross EJ, Sanchez Alvarado A, Hawley RS. Proc Natl Acad Sci U S A. 2014;111:E5159-E5168.
Original Data

Topoisomerase II is required for the proper separation of heterochromatic regions during Drosophila female meiosis.
Hughes SE, Hawley RS. PLoS Genet. 2014;10:e1004650.
Original Data

Corolla is a novel protein that contributes to the architecture of the synaptonemal complex of Drosophila.
Collins KA, Unruh JR, Slaughter BD, Yu Z, Lake CM, Nielsen RJ, Box KS, Miller DE, Blumenstiel JP, Perera AG, Malanowski KE, Hawley RS. Genetics. 2014;198:219-228.
Original Data

Discovery of Supernumerary B Chromosomes in Drosophila melanogaster.
Bauerly E, Hughes SE, Vietti DR, Miller DE, McDowell W, Hawley RS. Genetics. 2014;196:1007-1016.
Original Data

Reviews, Commentaries, Chapters or Books

Tetrad analysis in the mouse.
Miller DE, Hawley RS. Nat Genet. 2014;46:1045-1046.

2013

Original Research Papers

Comparing Zinc Finger Nucleases and Transcription Activator-Like Effector Nucleases for Gene Targeting in Drosophila.
Beumer KJ, Trautman JK, Christian M, Dahlem TJ, Lake CM, Hawley RS, Grunwald DJ, Voytas DF, Carroll D. G3 (Bethesda).2013;3:1717-1725.
Original Data

A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.
Whitfield ZJ, Chisholm J, Hawley RS, Orr-Weaver TL. PLoS Biol. 2013;11:e1001648.
Original Data

The Development of a Monoclonal Antibody Recognizing the Drosophila melanogaster Phosphorylated Histone H2A Variant (gamma-H2AV).
Lake CM, Holsclaw JK, Bellendir SP, Sekelsky J, Hawley RS. G3 (Bethesda). 2013;3:1539-1543.
Original Data

Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.
Bonner AM, Hughes SE, Chisholm JA, Smith SK, Slaughter BD, Unruh JR, Collins KA, Friederichs JM, Florens L, Swanson SK, Pelot MC, Miller DE, Washburn MP, Jaspersen SL, Hawley RS. Proc Natl Acad Sci U S A. 2013;110:E1222-1231.
Original Data

Reviews, Commentaries, Chapters or Books

Flies get a head start on meiosis.
Cahoon CK, Hawley RS. PLoS Genet. 2013;9:e1004051.

Chromosome Movement.
Collins KA, Jaspersen SL, Hawley RS. In: S Maloy, and K Hughes, eds. Brenner's Online Encyclopedia of Genetics. 2nd Edition ed: Academic Press; 2013.

RNF212 marks the spot.
Lake CM, Hawley RS. Nat Genet. 2013;45:228-229.

2012

Original Research Papers

A germline clone screen on the X chromosome reveals novel meiotic mutants in Drosophila melanogaster.
Collins KA, Callicoat JG, Lake CM, McClurken CM, Kohl KP, Hawley RS. G3. 2012;2:1369-1377.
Original

Data
Shaggy/glycogen synthase kinase 3beta and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis.
Takeo S, Swanson SK, Nandanan K, Nakai Y, Aigaki T, Washburn MP, Florens L, Hawley RS. Proc Natl Acad Sci U S A. 2012;109:6382-6389.
Original Data

A Whole-Chromosome Analysis of Meiotic Recombination in Drosophila melanogaster.
Miller DE, Takeo S, Nandanan K, Paulson A, Gogol MM, Noll AC, Perera AG, Walton KN, Gilliland WD, Li H, Staehling KK, Blumenstiel JP, Hawley RS. G3 (Bethesda). 2012;2:249-260.

Reviews, Commentaries, Chapters or Books

Bisphenol A and the primate ovary.
Miller DE, Hawley RS. Proc Natl Acad Sci U S A. 2012;109:17315-17316.

The other life of articles.
Hawley RS, Ruedi EA. Genetics. 2012;191:1029.

Rumors of its disassembly have been greatly exaggerated: the secret life of the synaptonemal complex at the centromeres.
Takeo S, Hawley RS. PLoS Genet. 2012;8:e1002807.

The molecular control of meiotic chromosomal behavior: events in early meiotic prophase in Drosophila oocytes.
Lake CM, Hawley RS. Annu Rev Physiol. 2012;74:425-451.

2011

Original Research Papers

Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in Drosophila oocytes.Takeo S, Lake CM, Morais-de-Sa E, Sunkel CE, Hawley RS. Curr Biol. 2011;21:1845-1851. Gamma-Tubulin Is Required for Bipolar Spindle Assembly and for Proper Kinetochore Microtubule Attachments during Prometaphase I in Drosophila Oocytes.Hughes SE, Beeler JS, Seat A, Slaughter BD, Unruh JR, Bauerly E, Matthies HJ, Hawley RS. PLoS Genet. 2011;7:e1002209.
The Drosophila zinc finger protein trade embargo is required for double strand break formation in meiosis.
Lake CM, Nielsen RJ, Hawley RS. PLoS Genet. 2011;7:e1002005.

Reviews, Commentaries, Chapters or Books

Meiotic pairing as a polo match.
Jaspersen SL, Hawley RS. Dev Cell. 2011;21:805-806.

Solving a Meiotic LEGO(R) Puzzle: Transverse Filaments and the Assembly of the Synaptonemal Complex in Caenorhabditis elegans.
Hawley RS. Genetics. 2011;189:405-409.

Oogenesis: when most is good enough.
Hawley RS. Curr Biol. 2011;21:R288-290.

Hitting a tiny target in the dark.
Hawley RS. Molecular biology. Science 2011;331:870-871.

The Human Genome, A User's Guide.
Richards JE, Hawley RS. Third ed: Academic Press; 2011.

2010

Original Research Papers

Statistical analysis of nondisjunction assays in Drosophila.
Zeng Y, Li H, Schweppe NM, Hawley RS, Gilliland WD. Genetics. 2010;186:505-513.

Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila.
Takeo S, Hawley RS, Aigaki T. Dev Biol. 2010;344:957-967.

2009

Original Research Papers

Statistical analysis of nondisjunction assays in Drosophila.
Zeng Y, Li H, Schweppe NM, Hawley RS, Gilliland WD. Genetics. 2010;186:505-513.

Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila.
Takeo S, Hawley RS, Aigaki T. Dev Biol. 2010;344:957-967.

2008

Original Research Papers

Reviews, Commentaries, Chapters or Books

Synapsis, Double Strand Breaks, and Domains of Crossover Control in Drosophila Females
Mushegian A, Mehrotra S, Hawley RS, McKim KS. In: R Egel, ed. Recombination and Meiosis: Crossing-Over and Disjunction. Heidelberg: Springer Verlag 2008;2:125-151.

Matrimony ties Polo down: Can this kinase get free?
Smith SK, Jaspersen SL, Hawley RS. Cell Cycle.2008;7:698-701.

2007

Original Research Papers

The Multiple Roles of Mps1 in Drosophila Female Meiosis
Gilliland WD, Hughes SE, Cotitta JL, Takeo S, Xiang Y, Hawley RS. PLoS Genet.2007;3:e113.

The Formation of the Central Element of the Synaptonemal Complex May Occur by Multiple Mechanisms: The Roles of the N- and C-Terminal Domains of the Drosophila C(3)G Protein in Mediating Synapsis and Recombination
Jeffress JK, Page SL, Royer SK, Belden ED, Blumenstiel JP, Anderson LK, Hawley RS. Genetics.2007;177:2445-2456.

A Genetic Analysis of the Drosophila mcm5 Gene Defines a Domain Specifically Required for Meiotic Recombination
Lake CM, Teeter K, Page SL, Nielsen R, Hawley RS. Genetics.2007;176:2151-2163.

A Germline Clone Screen for Meiotic Mutants in Drosophila melanogaster
Page SL, Nielsen RJ, Teeter K, Lake CM, Ong S, Wright KR, Dean KL, Agne D, Gilliland WD, Hawley RS. Fly.2007;1:172-181.

Reviews, Commentaries, Chapters or Books

The Inhibition of Polo Kinase by Matrimony Maintains G2 Arrest in the Meiotic Cell Cycle
Xiang Y, Takeo S, Florens L, Hughes SE, Huo LJ, Gilliland WD, Swanson SK, Teeter K, Schwartz JW, Washburn MP, Jaspersen SL, Hawley RS. PLoS Biol.2007;5:2831-2846.

Meiosis in living color: Fluorescence-based tetrad analysis in Arabidopsis
Hawley RS. Proc Natl Acad Sci U S A.2007

Scrambling Eggs in Plastic Bottles
Hawley RS, Warburton D. PLoS Genet.2007;3:e6.

2006

Original Research Papers

Reviews, Commentaries, Chapters or Books

Proteomic Analysis by Multidimensional Protein Identification Technology
Hawley RS, Florens L, Washburn MP. Methods in Molecular Biology: New and Emerging Proteomics Techniques. Totowa, NJ: Humana Press Inc.; 2006;328:159-175.


Epilogue
Hawley RS. In: M Ashburner, ed. Won For All: How The Drosophila Genome Was Sequenced. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press; 2006. 75-90.

Sometimes the Result Is Not the Answer: The Truths and the Lies That Come From Using the Complementation Test
Hawley RS, Gilliland WD. Genetics.2006;174:5-15. Epigenetic Regulation of Chromosome InheritanceKarpen GH, Hawley RS. In: DC Allis, T Jenuwein, and D Reinberg, eds. Epigenetics. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press; 2006:265-289. [{Table of Contents||http://www.loc.gov/catdir/toc/ecip0620/2006028894.html}]

2005

Original Research Papers

Reviews, Commentaries, Chapters or Books

Homologous Chromosome Interactions in Meiosis: Diversity Amidst Conservation
Gerton JL, Hawley RS. Nat Rev Genet.2005;6:477-487.

Cohesin and the Maternal Age Effect
Gilliland WD, Hawley RS. Cell.2005;123:371-373.

A New Target for POLO in Meiotic Centromere Cohesion
Lake CM, Hawley RS. Dev Cell.2005;8:5-7.

The Human Genome: A User's Guide
Richards JE, Hawley RS. 2nd Ed. San Diego, Calif.: Elsevier Academic Press; 2005.

2004

Original Research Papers

A Large-Scale Screen for Mutagen-Sensitive Loci in Drosophila
Laurencon A, Orme CM, Peters HK, Boulton CL, Vladar EK, Langley SA, Bakis EP, Harris DT, Harris NJ, Wayson SM, Hawley RS, Burtis KC. Genetics.2004;167:217-231.

GermOnline, a cross-species community knowledgebase on germ cell differentiation
Wiederkehr C, Basavaraj R, Sarrauste de Menthiere C, Hermida L, Koch R, Schlecht U, Amon A, Brachat S, Breitenbach M, Briza P, Caburet S, Cherry M, Davis R, Deutschbauer A, Dickinson HG, Dumitrescu T, Fellous M, Goldman A, Grootegoed JA, Hawley R, Ishii R, Jegou B, Kaufman RJ, Klein F, Lamb N, Maro B, Nasmyth K, Nicolas A, Orr-Weaver T, Philippsen P, Pineau C, Rabitsch KP, Reinke V, Roest H, Saunders W, Schroder M, Schedl T, Siep M, Villeneuve A, Wolgemuth DJ, Yamamoto M, Zickler D, Esposito RE, Primig M. Nucleic Acids Res.2004;32 Database issue:D560-567.

Reviews, Commentaries, Chapters or Books

Evolution and Function of Processosome, the Complex That Assembles Ribosomes in Eukaryotes: Clues from Comparative Sequence Analysis
Page SL, Hawley RS, Mushegian A. Practical bioinformatics. Berlin ; New York: Springer; 2004;15:xvii, 265 p.

THE GENETICS AND MOLECULAR BIOLOGY OF THE SYNAPTONEMAL COMPLEX
Page SL, Hawley RS. Annu Rev Cell Dev Biol.2004;20:525-558. Drosophila : A Laboratory Handbook, 2nd EditionAshburner M, Hawley RS, Golic KG. Cold Springs Harbor Press; 2004.

2003

Original Research Papers

The Spindle-Associated Transmembrane Protein Axs Identifies a New Family of Transmembrane Proteins in Eukaryotes
Kramer J, Hawley RS. Cell Cycle. 2003;2:174-176.

The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle
Kramer J, Hawley RS. Nat Cell Biol. 2003;5: 261-263.

Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR
Laurencon A, Purdy A, Sekelsky J, Hawley RS, Su TT. Genetics. 2003;164:589-601.

Reviews, Commentaries, Chapters or Books

Human Meiosis: Model Organisms Address the Maternal Age Effect
Hawley RS. CurrBiol. 2003

The Human Y Chromosome: Rumors of Its Death Have Been Greatly Exaggerated
Hawley RS. Cell. 2003

Chromosome Choreography: The Meiotic Ballet
Page SL, Hawley RS. Science. 2003;301:785-789.

Meiosis: When Even Two Is a Crowd
van Veen E, Hawley RS. Curr Biol. 2003;13:R831-R833.

Advanced Genetic Analysis: Finding Meaning in the Genome
Hawley RS. New York, NY: Blackwell Science; 2003.

2002

Reviews, Commentaries, Chapters or Books

Playing for half the deck: the molecular biology of meiosis
Champion MD, Hawley RS. Nat Cell Biol. 2002;4 Suppl:s50-56.

Meiosis: How Male Flies Do Meiosis
Hawley RS. Curr Biol. 2002

2001

Reviews, Commentaries, Chapters or Books

Altered Nuclear Transport and the Most Selfish of Genes
Hawley RS. Dev Cell. 2001