Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation Krishnan J, Wang Y, Kenzior O, Hassan H, Olsen L, Tsuchiya D, Kenzior A, Peuss R, Xiong S, Wang Y, Zhao C, Rohner N. Sci Rep. 2022;12:10115. doi: 10110.11038/s41598-10022-14507-10110.  

The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and Ageing-Related metabolites
Medley JK, Persons J, Biswas T, Olsen L, Peuss R, Krishnan J, Xiong S, Rohner N. eLife. 2022;11:e74539. doi: 74510.77554/eLife.74539.  

Genome-wide analysis of cis-regulatory changes in the metabolic adaptation of cavefish
Krishnan J, Seidel CW, Zhang N, Singh NP, VanCampen J, Peuss R, Xiong S, Kenzior A, Li H, Conaway JW, Rohner N. Nat Genet. 2022;54:684-693.

Enhanced lipogenesis through Ppary helps cavefish adapt to food scarcity
Xiong S, Wang W, Kenzior A, Olsen L, Krishnan J, Persons J, Medley K, Peuss R, Wang Y, Chen S, Zhang N, Thomas N, Miles JM, Sánchez Alvarado A, Rohner N. [published ahead of print April 8 2022].Curr Biol. 2022.

Hybridization underlies localized trait evolution in cavefish
Moran RL, Jaggard JB, Roback EY, Kenzior A, Rohner N, Kowalko JE, Ornelas-Garcia CP, McGaugh SE, Keene AC. iScience. 2022;25:103778. doi: 103710.101016/j.isci.102022.103778.

Repeated evolution of circadian clock dysregulation in cavefish populations
Mack KL, Jaggard JB, Persons JL, Roback EY, Passow CN, Stanhope BA, Ferrufino E, Tsuchiya D, Smith SE, Slaughter BD, Kowalko J, Rohner N, Keene AC, McGaugh SE. PLoS Genet. 2021 Jul 12;17(7):e1009642.

Image3C, a multimodal image-based and label independent integrative method for single-cell analysis
Accorsi A, Box AC, Peuss R, Wood C, Sanchez Alvarado A, Rohner N. eLife. 2021;10. doi: 10.7554/eLife.65372.  

Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish
O'Gorman M, Thakur S, Imrie G, Moran RL, Choy S, Sifuentes-Romero I, Bilandzija H, Renner KJ, Duboue E, Rohner N, McGaugh SE, Keene AC, Kowalko JE. [published ahead of print July 23 2021]. Curr Biol. 2021.  

Lipid metabolism in adaptation to extreme nutritional challenges
Olsen L, Thum E, Rohner N. Dev Cell. 2021;56:1417-1429.  

A chromosome-level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution
Warren WC, Boggs TE, Borowsky R, Carlson BM, Ferrufino E, Gross JB, Hillier L, Hu Z, Keene AC, Kenzior A, Kowalko JE, Tomlinson C, Kremitzki M, Lemieux ME, Graves-Lindsay T, McGaugh SE, Miller JT, Mommersteeg MTM, Moran RL, Peuss R, Rice ES, Riddle MR, Sifuentes-Romero I, Stanhope BA, Tabin CJ, Thakur S, Yamamoto Y, Rohner N. Nat Commun. 2021;12:1447.

In the Spotlight-Early Career Researcher
Rohner N. J Exp Zool Pt B Mol Dev Evol. 2020;334:387-388.  

Introduction to the special issue - cavefish - adaptation to the dark
Kowalko JE, Franz-Odendaal TA, Rohner N. J Exp Zoo Pt B Mol Dev Evol. 2020;334:393-396.  

Untargeted Metabolomics of the Cavefish Astyanax mexicanus Reveals the Basis of Metabolic Strategies in Adaptation to Extreme Conditions
‍Medley JK, Persons J, Peuß R, Olsen L, Xiong S, Rohner N. bioRxiv 2020.10.27.358077; doi: https://doi.org/10.1101/2020.10.27.358077

Adaptation to low parasite abundance affects immune investment and immunopathological responses of cavefish.
Peuß R, Box AC, Chen S, WangY, Tsuchiya D, Persons JL, Kenzior A, Maldonado E, Krishnan J, Scharsack JP,Slaughter BD, Rohner N. Nat Ecol Evol. 2020 Jul 20. doi:10.1038/s41559-020-1234-2. Online ahead of print.PMID: 32690906

Dark world rises: The emergence of cavefish as a model for the study of evolution, development,behavior, and disease.
McGaugh SE, Kowalko JE,Duboué E, Lewis P, Franz-Odendaal TA, Rohner N, Gross JB, KeeneAC. J Exp Zool B Mol Dev Evol. 2020 Jul 7. doi: 10.1002/jez.b.22978. Online ahead of print. PMID: 32638529

Comparative transcriptome analysis of wild and lab populations of Astyanax mexicanus uncovers differential effects of environment and morphotype on gene expression [published online ahead of print, 2020 Feb 4].
Krishnan J, Persons JL, Peuss R, Hassan H, Kenzior A, Xiong S, Olsen L, Maldonado E, Kowalko JE, Rohner N.  J Exp Zool B Mol Dev Evol. 2020;10.1002/jez.b.22933. doi:10.1002/jez.b.22933

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia
Shimobayashi M, Shetty S, Frei IC, Wölnerhanssen BK, Weissenberger D, Dietz N, Thomas A, Ritz D, Meyer-Gerspach AC, Maier T, Hay N, Peterli R, Rohner N, Hall MN bioRxiv 2019.12.28.887794; doi: https://doi.org/10.1101/2019.12.28.887794

An Adult Brain Atlas Reveals Broad Neuroanatomical Changes in Independently Evolved Populations of Mexican Cavefish.
Loomis C, Peuss R, Jaggard JB, Wang Y, McKinney S, Raftopoulos A, Raftopoulos S, Whu D, Green MR, McGaugh SE, Rohner NE, Keene AC, Duboue ER. Front Neuroanat. 2019;13:88. Published 2019 Oct 4. doi:10.3389/fnana.2019.00088

Sweet fish: Fish models for the study of hyperglycemia and diabetes.
Krishnan J, Rohner N. J Diabetes. 2019;11(3):193–203. doi:10.1111/1753-0407.12860

Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system.
Stahl BA, Peuss R, McDole B, Kenzior A, Jaggard JB, Gaudenz K, Krishnan J, McGaugh SE, Duboue ER, Keene AC, Rohner N. Dev Dyn. 2019;248(8):679–687. doi:10.1002/dvdy.32

Gamete Collection and In Vitro Fertilization of Astyanax mexicanus.
Peuß R, Zakibe Z, Krishnan J, Merryman MS, Baumann DP, Rohner N.  J Vis Exp. 2019;(147):10.3791/59334. Published 2019 May 25. doi:10.3791/59334

Insulin resistance in cavefish as an adaptation to a nutrient-limited environment.
Biddle MR, Aspiras AC, Gaudenz K, Peuss R, Sung JY, Martineau B, Peavey M, Box AC, Tabin JA, McGaugh S, Borowsky R, Tabin CJ, Rohner N. Nature. 2018;555(7698):647–651. doi:10.1038/nature26136

Cavefish as an evolutionary mutant model system for human disease.
Rohner N. Dev Biol. 2018;441(2):355–357. doi:10.1016/j.ydbio.2018.04.013

Seeing a bright future for a blind fish.
Gore AV, Rohner N, Rétaux S, Jeffery WR. Dev Biol. 2018;441(2):207–208. doi:10.1016/j.ydbio.2018.08.004

Evolution: A Dark Past.
Rohner N. Curr Biol. 2018;28(20):R1190–R1192. doi:10.1016/j.cub.2018.08.045

Temperature preference of cave and surface populations of Astyanax mexicanus.
Tabin JA, Aspiras A, Martineau B, Riddle M, Kowalko J, Borowsky R, Rohner N, Tabin CJ. Dev Biol. 2018;441(2):338–344. doi:10.1016/j.ydbio.2018.04.017

CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.
Klaassen H, Wang Y, Adamski K, Rohner N, Kowalko JE. Dev Biol. 2018;441(2):313–318. doi:10.1016/j.ydbio.2018.03.014

Early adipogenesis contributes to excess fat accumulation in cave populations of Astyanax mexicanus.
Xiong S, Krishnan J, Peuß R, Rohner N. Dev Biol. 2018;441(2):297–304. doi:10.1016/j.ydbio.2018.06.003

The role of gene flow in rapid and repeated evolution of cave-related traits in Mexican tetra, Astyanax mexicanus.
Herman A, Brandvain Y, Weagley J, Jeffery WR, Keene AC, Kono TJY, Bilandzija H, Borowsky R, Espinasa L, O'Quin K, Ornelas-Garcia CP, Yoshizawa M, Carlson B, Maldonado E, Gross JB, Cartwright RA, Rohner N, Warren WC, McGaugh SE. Mol Ecol. 2018;27(22):4397–4416. doi:10.1111/mec.14877

Cavefish and the basis for eye loss.
Krishnan J, Rohner N. Philos Trans R Soc Lond B Biol Sci. 2017;372(1713):20150487. doi:10.1098/rstb.2015.0487

Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies.
Daane JM, Rohner N, Konstantinidis P, Djuranovic S, Harris MP. Mol Biol Evol. 2016;33(1):162–173. doi:10.1093/molbev/msv208

Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions.
Aspiras AC, Rohner N, Martineau B, Borowsky RL, Tabin CJ. Proc Natl Acad Sci U S A. 2015;112(31):9668–9673. doi:10.1073/pnas.1510802112

The cavefish genome reveals candidate genes for eye loss.
McGaugh SE, Gross JB, Aken B, Blin M, Borowsky R, Chalopin D, Hinaux H, Jeffery WR, Keene A, Ma L, Minx P, Murphy D, O'Quin KE, Rétaux S, Rohner N, Searle SM, Stahl BA, Tabin C, Volff JN, Yoshizawa M, Warren WC. Nat Commun. 2014;5:5307. Published 2014 Oct 20. doi:10.1038/ncomms6307

Development: facial makeup enhancing our looks.
Rohner N, Tschopp P, Tabin C. Curr Biol. 2014;24(1):R36–R38. doi:10.1016/j.cub.2013.11.026

Loss of schooling behavior in cavefish through sight-dependent and sight-independent mechanisms.
Kowalko JE, Rohner N, Rompani SB, Peterson BK, Linden TA, Yoshizawa M, Kay EH, Weber J, Hoekstra HE, Jeffery WR, Borowsky R, Tabin CJ. Curr Biol. 2013;23(19):1874–1883. doi:10.1016/j.cub.2013.07.056

The African coelacanth genome provides insights into tetrapod evolution.
Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SM, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K. Nature. 2013;496(7445):311–316. doi:10.1038/nature12027

Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
Rohner N, Jarosz DF, Kowalko JE, Yoshizawa M, Jeffery WR, Borowsky RL, Lindquist S, Tabin CJ. Science. 2013;342(6164):1372–1375. doi:10.1126/science.1240276

Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.
Smith JJ, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell MS, Yandell MD, Manousaki T, Meyer A, Bloom OE, Morgan JR, Buxbaum JD, Sachidanandam R, Sims C, Garruss AS, Cook M, Krumlauf R, Wiedemann LM, Sower SA, Decatur WA, Hall JA, Amemiya CT, Saha NR, Buckley KM, Rast JP, Das S, Hirano M, McCurley N, Guo P, Rohner N, Tabin CJ, Piccinelli P, Elgar G, Ruffier M, Aken BL, Searle SM, Muffato M, Pignatelli M, Herrero J, Jones M, Brown CT, Chung-Davidson YW, Nanlohy KG, Libants SV, Yeh CY, McCauley DW, Langeland JA, Pancer Z, Fritzsch B, de Jong PJ, Zhu B, Fulton LL, Theising B, Flicek P, Bronner ME, Warren WC, Clifton SW, Wilson RK, Li W. Nat Genet. 2013;45(4):415–421e4212. doi:10.1038/ng.2568

Convergence in feeding posture occurs through different genetic loci in independently evolved cave populations of Astyanax mexicanus.
Kowalko JE, Rohner N, Linden TA, Rompani SB, Warren WC, Borowsky R, Tabin CJ, Jeffery WR, Yoshizawa M. Proc Natl Acad Sci U S A. 2013;110(42):16933–16938. doi:10.1073/pnas.1317192110

Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome.
Norton WH, Stumpenhorst K, Faus-Kessler T, Folchert A, Rohner N, Harris MP, Callebert J, Bally-Cuif L. J Neurosci. 2011;31(39):13796–13807. doi:10.1523/JNEUROSCI.2892-11.2011

Enhancing the efficiency of N-ethyl-N-nitrosourea-induced mutagenesis in the zebrafish.
Rohner N, Perathoner S, Frohnhöfer HG, Harris MP. Zebrafish. 2011;8(3):119–123. doi:10.1089/zeb.2011.0703

Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication.
Rohner N, Bercsényi M, Orbán L, Kolanczyk ME, Linke D, Brand M, Nüsslein-Volhard C, Harris MP. Curr Biol. 2009;19(19):1642–1647. doi:10.1016/j.cub.2009.07.065

Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates.
Harris MP, Rohner N, Schwarz H, Perathoner S, Konstantinidis P, Nüsslein-Volhard C. PLoS Genet. 2008;4(10):e1000206. Published 2008 Oct 3. doi:10.1371/journal.pgen.1000206