Lab Members

Paul Trainor

Research in the Trainor laboratory focuses on the role of neural crest cells in vertebrate development, evolution and disease. We seek to understand the mechanisms that regulate neural crest cell formation, migration, and differentiation and to apply this basic knowledge to better understand the etiology and pathogenesis of birth defects as well as develop therapeutic avenues for their prevention. We are particularly interested in craniofacial development and currently study neurocristopathies such as Treacher Collins syndrome, Acrofacial Dysostosis - Cincinnati type, cleft lip and palate, and Syngnathia. However we also study the roles of neural crest cells in congenital disorders of the heart and gastrointestinal tract, such as persistent truncus arteriosus and Hirschsprung disease respectively. We use mouse and zebrafish as our primary genetic models, but also utilize chameleons, chickens and lizards in our experimental studies.

Kristin Watt

Postdoctoral Research Associate
My project involves using zebrafish and mice as model to study genes involved in craniofacial development, specifically Treacher-Collins syndrome and Acrofacial Dysostosis - Cincinnati type.

Predoctoral National Service Research Award (F31).

Karin Zueckert-Gaudenz

Research Specialist I
I very much enjoy working in a collegial environment and using my molecular biology background to advance the lab’s research of neural crest cell development.

Soma Dash

Postdoctoral Research Associate
It is truly intriguing that basic cellular processes such as ribosome biogenesis are associated with tissue-specific defects such as ribosomopathies. This indicates that there must be cell or tissue-specific regulatory aspects of ribosome synthesis. I am driven to identify the nature and molecular mechanism of such regulatory factors and their relation to developmental defects.

American Association for Anatomy Postdoctoral Fellow.

Sharien Fitriasari

Predoctoral Researcher
I am interested in understanding the events that lead to tissue-specific cell death in neurocristopathies, such as defects in DNA damage responses.

Natasha Shylo

Postdoctoral Research Associate
Neural crest cells have been studied extensively across model organisms and several evolutionary clades. As we are starting to gain a better genetic and molecular understanding for the signaling that undergoes in different model organisms as neural crest lineage becomes established and cells start migrating, we are finding inconsistent phenotypic differences between the genetic studies done in different model systems. Furthermore, some of the key questions remain unanswered. How early do cells become committed to the neural crest linage? What genes are involved in that process? Thus, I am hoping to better understand the early molecular events that lead to the establishment of the neural crest cell lineage in mouse.

Society for Developmental Biology Emerging Models Grant.

Maureen Lamb

Postdoctoral Research Associate
My project involves using human iPSCs to visualize changes in the morphology of the different nucleolar compartments when ribosome biogenesis is perturbed and using these cells to generate new disease models.

Emma Moore

Predoctoral Researcher
Craniofacial development is perhaps one of the most intricate and intriguing processes of development. Not only does it require an orchestration of pertinent signaling interactions and cellular dynamics to ensure proper development, but it also involves the artistic interpretation of genetic and environmental inputs to generate the features unique to each of our faces. As a lab we study neural crest cells which give rise to the craniofacial bone and cartilage. My project is specifically focused on understanding the signals and cellular changes required to achieve a key step in neural crest cell development – epithelial to mesenchymal transition.

Ruonan Zhao

Predoctoral Researcher
I first became interested in neural crest cells because they share similar behaviors with cancer cells. Both cell types can undergo a process called epithelial to mesenchymal transition (EMT), which gives them the mobility for migration. Currently, most of our knowledge about neural crest EMT came from studies in non-mammalian species. However, there has been differences in loss-of-function phenotypes between mouse and non-mammalian models indicating that there might be differences in the neural crest gene regulatory network between non-mammalian and mammalian species. By using several mouse models previously established in the lab, my goal is to better understand the neural crest EMT gene regulatory network in mammalian species.

Blanka Mrazkova

Visiting Scientist
My project focuses on two genes, Trabd2b and Rps19, which play a role in mouse brain and head development. As a visiting scientist, I came to the Trainor Lab to learn new techniques that will help me to describe the phenotypes of mice with mutations in these genes, and to understand their mechanisms of action.

Carolyn Hacker

Senior Administrative Assistant
I have been the senior administrative assistant in the Trainor Lab since May 2007. My responsibilities include the efficient operations of the lab on a daily basis.