Publications
2023
Hypomylination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy.
Michell-Robinson M, Watt K, Grouza V, Macintosh J, Pinard M, Tuznik M, Chen X, Darbelli L, Wu C, Perrier S, Chitsaz D, Uccelli N, Liu H, Cox T, Muller C, Kennedy T, Coulombe B, Rudko D, Trainor PA, Bernard, G.
Brain. 2023 Apr 14:S0002-9297(23)00098-8. doi: 10.1016/j.ajhg.2023.03.014.
Michell-Robinson M, Watt K, Grouza V, Macintosh J, Pinard M, Tuznik M, Chen X, Darbelli L, Wu C, Perrier S, Chitsaz D, Uccelli N, Liu H, Cox T, Muller C, Kennedy T, Coulombe B, Rudko D, Trainor PA, Bernard, G.
Brain. 2023 Apr 14:S0002-9297(23)00098-8. doi: 10.1016/j.ajhg.2023.03.014.
rRNA transcription is integral to phase separation and maintenance of nucleolar structure.
Dash S, Lamb M, Lange J, McKinney C, Tsuchiya D, Guo F, Zhoa X, Corbin T, Kirkman M, Delventhal K, Moore E, McKinney S, Shiang R, Trainor PA.
PLOS Genetics. 2023 Apr 14:S0002-9297(23)00098-8. doi: 10.1016/j.ajhg.2023.03.014.
Dash S, Lamb M, Lange J, McKinney C, Tsuchiya D, Guo F, Zhoa X, Corbin T, Kirkman M, Delventhal K, Moore E, McKinney S, Shiang R, Trainor PA.
PLOS Genetics. 2023 Apr 14:S0002-9297(23)00098-8. doi: 10.1016/j.ajhg.2023.03.014.
POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies.
Smallwood K, Watt KEN, Ide S, Baltrunaite K, Brunswick C, Inskeep K, Capannari C, Adam MP, Begtrup A, Bertola DR, Demmer L, Demo E, Devinsky O, Gallagher ER, Guillen Sacoto MJ, Jech R, Keren B, Kussmann J, Ladda R, Lansdon LA, Lunke S, Mardy A, McWalters K, Person R, Raiti L, Saitoh N, Saunders CJ, Schnur R, Skorvanek M, Sell SL, Slavotinek A, Sullivan BR, Stark Z, Symonds JD, Wenger T, Weber S, Whalen S, White SM, Winkelmann J, Zech M, Zeidler S, Maeshima K, Stottmann RW, Trainor PA, Weaver KN.
Am J Hum Genet. 2023 Apr 14:S0002-9297(23)00098-8. doi: 10.1016/j.ajhg.2023.03.014. Online ahead of print.
Smallwood K, Watt KEN, Ide S, Baltrunaite K, Brunswick C, Inskeep K, Capannari C, Adam MP, Begtrup A, Bertola DR, Demmer L, Demo E, Devinsky O, Gallagher ER, Guillen Sacoto MJ, Jech R, Keren B, Kussmann J, Ladda R, Lansdon LA, Lunke S, Mardy A, McWalters K, Person R, Raiti L, Saitoh N, Saunders CJ, Schnur R, Skorvanek M, Sell SL, Slavotinek A, Sullivan BR, Stark Z, Symonds JD, Wenger T, Weber S, Whalen S, White SM, Winkelmann J, Zech M, Zeidler S, Maeshima K, Stottmann RW, Trainor PA, Weaver KN.
Am J Hum Genet. 2023 Apr 14:S0002-9297(23)00098-8. doi: 10.1016/j.ajhg.2023.03.014. Online ahead of print.
Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus).
Shylo N, Smith S, Price, A, Guo F, McClain M, Trainor PA.
Front Cell Dev Biol. 2023 April 11; 11:11:1132166. doi: 10.1002/ase2278.
Shylo N, Smith S, Price, A, Guo F, McClain M, Trainor PA.
Front Cell Dev Biol. 2023 April 11; 11:11:1132166. doi: 10.1002/ase2278.
Personal Autonomy and Self-Determination are Crucial for Professionalism in Healthcare.
Organ JM, Smith HF, Trainor PA, Allen K, Balta J, Beresheim AB, Brewer-Deluce D, Brown KM, Burrows AM, Byers KT, Byram JN, Cale AS, Carroll MA, Champney T, Cornwall J, Dayal MR, DeLeon VB, Dunnwald M, Ferrigno C, Finn GM, Fox GM, Geller PL, Guttmann GD, Harper N, Harrell KM, Hartstone-Rose A, Hildebrandt S, Hortsch M, Jackson J, Johnson LE, Lohman Bonfiglio CM, McCumber TL, Menegaz RA, Mussell JC, O'Loughlin VD, Otobo T, Oyedele O, Pascoe MA, Person D, Reidenberg JS, Robinson RE, Rogers KA, Ros MA, Ross CF, Sanders KA, Schmitt B, Schoenwolf GC, Smith TD, Smith TC, Sumner DR, Taylor AB, Taylor MJ, Teaford MF, Topp KS, Willmore KE, Wisco JJ, Yang J, Zumwalt AC.
Anat Sci Educ. 2023 April 4. doi: 10.1002/ase2278. Online ahead of print.
Organ JM, Smith HF, Trainor PA, Allen K, Balta J, Beresheim AB, Brewer-Deluce D, Brown KM, Burrows AM, Byers KT, Byram JN, Cale AS, Carroll MA, Champney T, Cornwall J, Dayal MR, DeLeon VB, Dunnwald M, Ferrigno C, Finn GM, Fox GM, Geller PL, Guttmann GD, Harper N, Harrell KM, Hartstone-Rose A, Hildebrandt S, Hortsch M, Jackson J, Johnson LE, Lohman Bonfiglio CM, McCumber TL, Menegaz RA, Mussell JC, O'Loughlin VD, Otobo T, Oyedele O, Pascoe MA, Person D, Reidenberg JS, Robinson RE, Rogers KA, Ros MA, Ross CF, Sanders KA, Schmitt B, Schoenwolf GC, Smith TD, Smith TC, Sumner DR, Taylor AB, Taylor MJ, Teaford MF, Topp KS, Willmore KE, Wisco JJ, Yang J, Zumwalt AC.
Anat Sci Educ. 2023 April 4. doi: 10.1002/ase2278. Online ahead of print.
2022
Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.
Chang YC, Manent J, Schroeder J, Wong SFL, Hauswirth GM, Shylo NA, Moore EL, Achilleos A, Garside V, Polo JM, Trainor PA, McGlinn E.
Nat Commun. 2022 Dec 15;13(1):7766. doi: 10.1038/s41467-022-35303-4.
Chang YC, Manent J, Schroeder J, Wong SFL, Hauswirth GM, Shylo NA, Moore EL, Achilleos A, Garside V, Polo JM, Trainor PA, McGlinn E.
Nat Commun. 2022 Dec 15;13(1):7766. doi: 10.1038/s41467-022-35303-4.
Gene-environment interactions in the pathogenesis of common craniofacial anomalies.
Fitriasari S, Trainor PA.
Curr Top Dev Biol. 2023;152:139-168. doi: 10.1016/bs.ctdb.2022.10.005. Epub 2022 Nov 29.
Fitriasari S, Trainor PA.
Curr Top Dev Biol. 2023;152:139-168. doi: 10.1016/bs.ctdb.2022.10.005. Epub 2022 Nov 29.
Deciphering the role of retinoic acid in hepatic patterning and induction in the mouse.
Guertin TM, Palaria A, Mager J, Sandell LL, Trainor PA, Tremblay KD.
Dev Biol. 2022 Nov;491:31-42. doi: 10.1016/j.ydbio.2022.08.003. Epub 2022 Aug 23.
Guertin TM, Palaria A, Mager J, Sandell LL, Trainor PA, Tremblay KD.
Dev Biol. 2022 Nov;491:31-42. doi: 10.1016/j.ydbio.2022.08.003. Epub 2022 Aug 23.
Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development.
Falcon KT, Watt K, Dash S, Zhao R, Sakai D, Moore E, Fitriasari S, Childers M, Sardiu M, Swanson S, Tsuchiya D, Unruh J, Bugarinovic G, Li L, Shiang R, Achilleos A, Dixon J, Dixon M, Trainor PA.
Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2116974119. doi: 10.1073/pnas.2116974119. Epub 2022 Jul 26.
Falcon KT, Watt K, Dash S, Zhao R, Sakai D, Moore E, Fitriasari S, Childers M, Sardiu M, Swanson S, Tsuchiya D, Unruh J, Bugarinovic G, Li L, Shiang R, Achilleos A, Dixon J, Dixon M, Trainor PA.
Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2116974119. doi: 10.1073/pnas.2116974119. Epub 2022 Jul 26.
Single-cell transcriptomic signatures and gene regulatory networks modulated by W1s in mammalian midline facial formation and clefts.
Gu R, Zhang S, Kumar Saha S, Yu J, Reynolds K, McMahon M, Sun B, Islam M, Trainor PA, Chen P, Xu Y, Chai Y, Burkart-Waco D, Zhou C.
Development. 2022 Jul 15;149(14):dev200533. doi: 10.1242/dev.200533. Epub 2022 Jul 22.
Gu R, Zhang S, Kumar Saha S, Yu J, Reynolds K, McMahon M, Sun B, Islam M, Trainor PA, Chen P, Xu Y, Chai Y, Burkart-Waco D, Zhou C.
Development. 2022 Jul 15;149(14):dev200533. doi: 10.1242/dev.200533. Epub 2022 Jul 22.
Nucleolin loss of function leads to aberrant Fibroblast Growth Factor signaling and craniofacial anomalies.
Dash S, Trainor PA.
Development. 2022 Jun 15;149(12):dev200349. doi: 10.1242/dev.200349. Epub 2022 Jun 28.
Dash S, Trainor PA.
Development. 2022 Jun 15;149(12):dev200349. doi: 10.1242/dev.200349. Epub 2022 Jun 28.
RNA Polymerases I and III in development and disease.
Watt K, Macintosh J, Bernard G, Trainor PA.
Semin Cell Dev Biol. 2022. doi.org/10.1016/j.semcdb.2022.02.2018. Online ahead of print.
Watt K, Macintosh J, Bernard G, Trainor PA.
Semin Cell Dev Biol. 2022. doi.org/10.1016/j.semcdb.2022.02.2018. Online ahead of print.
Epithelial to mesenchymal transition during mammalian neural crest cell delamination.
Zhao R, Trainor PA.
Semin Cell Dev Biol. 2022. doi.org/10.1016/j.semcdb.2022.02.2018. Online ahead of print.
Zhao R, Trainor PA.
Semin Cell Dev Biol. 2022. doi.org/10.1016/j.semcdb.2022.02.2018. Online ahead of print.
Standardized Statement for the Ethical Use of Human Cadaveric Tissues in Anatomy Research Papers: Recommendations from Anatomical Journal Editors-In-Chief.
Iwanaga J, Singh V, Takeda S, Ogeng'o J, Kim H, Morys J, Satish Ravi K, Ribatti D, Trainor PA, Ramon Sanudo J, Apaydin N, Sharma A, Smith HF, Walocha J, Hegazy A, Duparc F, Paulsen F, Del Sol M, Adds P, Louryan S, Sassoli Fazan V, Tubbs R.
Clin Anat. 2022 Feb 26. doi: 10.1002/ca.23849. Online ahead of print.
Iwanaga J, Singh V, Takeda S, Ogeng'o J, Kim H, Morys J, Satish Ravi K, Ribatti D, Trainor PA, Ramon Sanudo J, Apaydin N, Sharma A, Smith HF, Walocha J, Hegazy A, Duparc F, Paulsen F, Del Sol M, Adds P, Louryan S, Sassoli Fazan V, Tubbs R.
Clin Anat. 2022 Feb 26. doi: 10.1002/ca.23849. Online ahead of print.
Retinoic Acid Deficiency Underlies the Etiology of Midfacial Defects.
Wu Y, Kurosaka H, Wang Q, Inubushi T, Nakatsugawa K, Kikuchi M, Ohara H, Tsujimoto T, Natsuyama S, Shida Y, Sandell LL, Trainor PA, Yamashiro T. 2022. J Dent Res. 220345211062049. doi: 10.1177/00220345211062049. Online ahead of print.
Wu Y, Kurosaka H, Wang Q, Inubushi T, Nakatsugawa K, Kikuchi M, Ohara H, Tsujimoto T, Natsuyama S, Shida Y, Sandell LL, Trainor PA, Yamashiro T. 2022. J Dent Res. 220345211062049. doi: 10.1177/00220345211062049. Online ahead of print.
Live Imaging of the Dynamics of Mammalian Neural Crest Cell Migration.
Moore E, Trainor PA. 2022. Methods Mol Biol. 2403:263-276. doi: 10.1007/978-1-0716-1847-9_18.
Moore E, Trainor PA. 2022. Methods Mol Biol. 2403:263-276. doi: 10.1007/978-1-0716-1847-9_18.
Comparative development of limb musculature in phylogenetically and ecologically divergent lizards.
Diaz RE Jr, Taylor-Diaz E, Trainor PA, Diogo R, Molnar J. Dev Dyn. 2021 Dec 19. doi: 10.1002/dvdy.447. Online ahead of print.
Diaz RE Jr, Taylor-Diaz E, Trainor PA, Diogo R, Molnar J. Dev Dyn. 2021 Dec 19. doi: 10.1002/dvdy.447. Online ahead of print.
2021
Acknowledging the use of human cadaveric tissues in research papers: Recommendations from anatomical journal editors.
Iwanaga J, Singh V, Ohtsuka A, Hwang Y, Kim HJ, Morys J, Ravi KS, Ribatti D, Trainor PA, Sanudo JR, Apaydin N, Sengul G, Albertine KH, Walocha JA, Loukas M, Duparc F, Paulsen F, Del Sol M, Adds P, Hegazy A, Tubbs RS. Clin Anat. 2021;34:2-4.
Iwanaga J, Singh V, Ohtsuka A, Hwang Y, Kim HJ, Morys J, Ravi KS, Ribatti D, Trainor PA, Sanudo JR, Apaydin N, Sengul G, Albertine KH, Walocha JA, Loukas M, Duparc F, Paulsen F, Del Sol M, Adds P, Hegazy A, Tubbs RS. Clin Anat. 2021;34:2-4.
Med23 Regulates Sox9 Expression during Craniofacial Development
Dash S, Bhatt S, Falcon KT, Sandell LL, Trainor PA. 2021. J Dent Res. 100(4):406-414.2021.
Dash S, Bhatt S, Falcon KT, Sandell LL, Trainor PA. 2021. J Dent Res. 100(4):406-414.2021.
Branchiomeric Muscle Development Requires Proper Retinoic Acid Signaling.
Wang, Q, Xu L, Miura J, Saha MK, Uemura Y, Sandell LL, Trainor PA, Yamashiro T, Kurosaka H. 2021. Front Cell Dev Biol. 9:596838. doi: 10.3389/fcell.2021.596838.
Wang, Q, Xu L, Miura J, Saha MK, Uemura Y, Sandell LL, Trainor PA, Yamashiro T, Kurosaka H. 2021. Front Cell Dev Biol. 9:596838. doi: 10.3389/fcell.2021.596838.
Synergistic role of retinoic acid signaling and Gata3 during primitive choanae formation.
Kurosaka H, Mushiake J, Mithun S, Wu Y, Wang Q, Kikuchi M, Nakaya A, Yamamoto S, Inubushi T, Koga S, Sandell LL, Trainor PA, Yamashiro T. 2021. Hum Mol Genet. ddab205. doi:10.1093/hmg/ddab205.
Kurosaka H, Mushiake J, Mithun S, Wu Y, Wang Q, Kikuchi M, Nakaya A, Yamamoto S, Inubushi T, Koga S, Sandell LL, Trainor PA, Yamashiro T. 2021. Hum Mol Genet. ddab205. doi:10.1093/hmg/ddab205.
Diabetes Oxidative Stress, and DNA Damage Modulate Cranial Neural Crest Cell Development and the Phenotype Variability of Craniofacial Disorders.
Fitriasari S, Trainor PA. 2021. Front Cell Dev Biol. 9:644410. doi: 10.3389/fcell.2021.644410.
Fitriasari S, Trainor PA. 2021. Front Cell Dev Biol. 9:644410. doi: 10.3389/fcell.2021.644410.
Ocular elongation and retraction in foveated reptiles.
Rasys AM, Pau SH, Irwin KE, Luo S, Kim HQ, Wahle MA, Trainor PA, Menke DB, Lauderdale JD. 2021. Dev Dyn. 250(11):1584-1599. doi: 10.1002/dvdy.348.
Rasys AM, Pau SH, Irwin KE, Luo S, Kim HQ, Wahle MA, Trainor PA, Menke DB, Lauderdale JD. 2021. Dev Dyn. 250(11):1584-1599. doi: 10.1002/dvdy.348.
2020
The Mediator subunit, Med23 is required for embryonic survival and regulation of canonical WNT signaling during cranial ganglia development
Dash S, Bhatt S, Sandell L, Seidel C, Ahn Y, Krumlauf R, Trainor P. Front Physiol. 2020;11:531933. doi: 531910.533389/fphys.532020.531933.
Dash S, Bhatt S, Sandell L, Seidel C, Ahn Y, Krumlauf R, Trainor P. Front Physiol. 2020;11:531933. doi: 531910.533389/fphys.532020.531933.
Pak1ip1 loss-of-function leads to cell cycle arrest, loss of neural crest cells, and craniofacial abnormalities
Panoutsopoulos AA, De Crescenzo A, Lee A, Lu AM, Ross AP, Yarov-Yarovoy V, Borodinsky L, Marcucio R, Trainor P, Zarbalis K. Front Cell Dev Biol. 2020;8:510063. doi: 510010.513389/fcell.512020.510063.
Panoutsopoulos AA, De Crescenzo A, Lee A, Lu AM, Ross AP, Yarov-Yarovoy V, Borodinsky L, Marcucio R, Trainor P, Zarbalis K. Front Cell Dev Biol. 2020;8:510063. doi: 510010.513389/fcell.512020.510063.
Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis
Ono K, Sandell LL, Trainor PA, Wu DK. 2020. Development 147(15):dev192070. doi: 10.1242/dev.192070.
Ono K, Sandell LL, Trainor PA, Wu DK. 2020. Development 147(15):dev192070. doi: 10.1242/dev.192070.
37/67-laminin receptor facilitates neural crest cell migration during enteric nervous system development
Fu M, Barlow-Anacker AJ, Kuruvilla KP, Bowlin GL, Seidel CW, Trainor PA, FASEB J. 2020;34:10931–10947.
Fu M, Barlow-Anacker AJ, Kuruvilla KP, Bowlin GL, Seidel CW, Trainor PA, FASEB J. 2020;34:10931–10947.
The Society for Craniofacial Genetics and Developmental Biology 42nd Annual Meeting
Eisenhoffer GT, Jr., Clouthier D, Cox T, Saint-Jeannet JP, Taneyhill LA, Trainor PA, Moody SA. Am J Med Genet A. 2020;182:1555-1561.
Eisenhoffer GT, Jr., Clouthier D, Cox T, Saint-Jeannet JP, Taneyhill LA, Trainor PA, Moody SA. Am J Med Genet A. 2020;182:1555-1561.
Identifying vitamin A signaling by visualizing gene and protein activity, and by quantification of vitamin A metabolites
Shannon SR, Yu J, Defnet AE, Bongfeldt D, Moise AR, Kane MA, Trainor PA. Methods Enzymol. 2020;637:367-418.
Shannon SR, Yu J, Defnet AE, Bongfeldt D, Moise AR, Kane MA, Trainor PA. Methods Enzymol. 2020;637:367-418.
The development, patterning and evolution of neural crest cell differentiation into cartilage and bone.
Dash S, Trainor PA. (2020) Bone. 137:115409. doi:10.1016/j.bone.2020.11540
Dash S, Trainor PA. (2020) Bone. 137:115409. doi:10.1016/j.bone.2020.11540
Perturbed development of cranial neural crest cells in association with reduced sonic hedgehog signaling underlies the pathogenesis of retinoic-acid-induced cleft palate.
Wang Q, Kurosaka H, Kikuchi M, Nakaya A, Trainor PA, Yamashiro T. (2020) Disease Models and Mechanisms 12(10):dmm040279
Wang Q, Kurosaka H, Kikuchi M, Nakaya A, Trainor PA, Yamashiro T. (2020) Disease Models and Mechanisms 12(10):dmm040279
2019
Filling in the phylogenetic gaps: Induction, migration, and differentiation of neural crest cells in a squamate reptile, the veiled chameleon (Chamaeleo calyptratus).
Diaz RE Jr, Shylo NA, Roellig D, Bronner M, Trainor PA. (2019) Developmental Dynamics 248(8):709-727
The transcriptome of the veiled chameleon (Chamaeleo calyptratus): A resource for studying the evolution and development of vertebrates.
Pinto BJ, Card DC, Castoe TA, Diaz RE Jr, Nielsen SV, Trainor PA, Gamble T. (2019) Developmental Dynamics 248(8):702-708
The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. (2019) Am J Med Genet A 179(5):864-869
An integrative view of Lepidosaur cranial anatomy, development and diversification.
Diaz, Jr. R.E. and Trainor, P.A. (2019). In: Heads, Jaws and Muscles Anatomical, Functional and Developmental Diversity in Chordate Evolution (Ziermann, Diaz Jr., Diogo eds). Springer.
Mouse embryo culture for the study of neural crest cells.
Munoz, W. and Trainor, P.A. (2019). In: Neural Crest Cells Methods and Protocols (Schwarz and Wiszniack eds). Methods Mol Biol. 2019;1976:107-119
2018
Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion.
Inman K.E., Caiaffa C.D., Melton K.R., Sandell L.L., Achilleos A., Kume T. and Trainor P.A. (2018) Developmental Dynamics 247(12):1286-1296
DAPI staining of whole-mount mouse embryos or fetal organs
Sandell L, Inman, K and Trainor P. (2018). Cold Spring Harbor Protocols (10):pdb.prot094029
tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis - Cincinnati type.
Noack Watt, K.E., Neben, C., Hall, S., Merrill, A.M. and Trainor, P.A. (2018). Human Molecular Genetics 27(15):2628-2643
Alterations in RA signaling affect the development of the mouse coronary vasculature.
Wang, S., Huang, W., Castillo, H.A., Kane, M.A., Xavier-Neto, J., Trainor, P.A. and Moise, A.R. (2018). Developmental Dynamics 247(8):976-991
The Society for Craniofacial Genetics and Developmental Biology 40th Annual Meeting.
Gammill, L., Cox, T., Moody, S., Taneyhill, L., Trainor, P.A. and Marcucio, R. (2018). American Journal Medical Genetics A. 176(5):1270-1273
Retinoic acid signalling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
Wang, S., Yu, J., Jones, J.W., Pierzchalski, K., Kane, M.A., Trainor, P.A., Xavier-Neto, J. and Moise, A.R. (2018). FASEB J 32(7):3765-3781
Dynamic sex chromosomes in Old World chameleons (Squamata: Chamaeleonidae).
Nielsen, S.V., Banks, J.L., Diaz Jr. R.E., Trainor, P.A. and Gamble, T. (2018). Journal of Evolutionary Biology 31(4):484-490
Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.
Iulianella, A., Sakai, D., Kurosaka, H. and Trainor, P.A. (2018). Developmental Dynamics 247(1):170-184
Developmental biology - more dynamic than ever!
Trainor, P.A. (2018). Developmental Dynamics 247(1):8-9
Neural crest cells and their application in regenerative medicine.
Trainor, P.A. (2018) In: Ten Cate's Oral Histology - Development, Structure and Function. 9th Edition p21-22. (Ed Antonio Nanci) Mosby Elsevier, St. Louis
2017
Lifting the veil on reptile embryology: the Veiled Chameleon (Chamaeleo calyptratus) as a model system to study reptilian development.
Diaz Jr, R.E., Bertocchini, F., Trainor, P.A. (2017). Methods in Molecular Biology 1650:269-284
Rdh10 loss-of-function and perturbed retinoid signalling underlies the etiology of choanal atresia.
Kurosaka, H., Wang, Q., Sandell, L.L., Yamashiro, T. and Trainor, P.A. (2017). Human Molecular Genetics 26(7): 1268-1279
New insights and changing paradigms in the regulation of vitamin A metabolism in development.
Shannon, S., and Moise, A., and Trainor, P.A. (2017). WIRES Developmental Biology wdev.264
The Society for Craniofacial Genetics and Developmental Biology 39th Annual Meeting.
Fish, J., Albertson, R.C., Harris, M., Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2017). Am J Med Genet A 173(4):985-1006
Rare syndromes of the head and face - Mandibulofacial and Acrofacial dysostoses.
Terrazas, K., Dixon, J., Trainor, P.A. and Dixon, M.J. (2017). WIRES Developmental Biology wdev.263
Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.
Amin, M. B., Miura, N., Uddin, M.K.F., Islam, M.J., Yoshida, N., Iseki, S., Kume, T., Trainor, P.A. Saitsu, H. and Aoto, K. (2017). Congenital Anomalies 57(1):24-31
2016
Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.
Sakai, D. and Trainor, P.A. (2016). Dev Growth Differ 58(7):577-85
The roles of RNA Polymerase 1 subunits Polr1c and Polr1d in craniofacial development and the pathogenesis of Treacher Collins syndrome.
Noack Watt, K.E., Achilleos, A., Neben, C., Merrill, A.M. and Trainor, P.A. (2016). PLOS Genetics 12(7):e1006187
Transcription factor TLX1 Controls Retinoic Acid Signaling to Ensure Spleen Development.
Lenti, E., Farinello, D., Yokoyama, K., Penkov, D., Castagnaro, L., Lavorgna. G., Wuputra. K., Sandel, L. L., Butler Tjaden N. E., Bernassola, F., Caridi, N., De Antoni, A., Wagner, M., Kozinc, K., Neiderreither, K., Blasi, F., Pasini, D., Majdic, G., Tonon, G., Trainor, P.A. and Brendolan, A (2016). J Clinical Investigation 126(7):2452-64
Developmental Biology: We are all Walking Mutants.
Trainor, P.A. (2016). Essays on Developmental Biology (P Wassarman: Ed) Elsevier, New York. Curr Topics Dev Biol 117:523-538
A quantitative method for defining high-arched palate using the Tcof1+/- mutant mouse as a model.
Conley, Z.R., Hague, M., Kurosaka, H., Dixon, J., Dixon, M.J and Trainor, P.A. (2016). Developmental Biology 415(2):296-305
The Society for Craniofacial Genetics and Developmental Biology 38th Annual Meeting.
Taneyhill. L., Hoover-Fong, J. Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2016). Am J Med Genet A 170(7):1732-5
Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation.
Sakai D., Dixon J., Achilleos, A., Dixon M.J. and Trainor P.A. (2016). Nature Communications 7:10328
2015
Mouse Models of Rare Craniofacial Disorders. In: Craniofacial Development (Yang Chai, editor).
Achilleos, A. and Trainor, P.A. (2015). Curr Topics Dev Biol 115:411-458. Academic Press, UK
Retinoic Acid Activity in Undifferentiated Neural Progenitors is Sufficient to Fulfil its Role in Restricting Fgf8 Expression for Somitogenesis.
Cunningham. T.J., Kumar, S., Brade, T., Sandell, L.L., Lewandoski, M., Trainor, P.A., Colas, A., Mercola, M. and Duester, G. (2015). PLOS One 10(9):e0137894
The mighty chondrocyte. No bones about it!
Purcell, P. and Trainor, P.A. (2015). J. Dental Research 94(12):1625-7
Hand/foot splitting and the "re-evolution’ of mesopodial elements during the evolution and radiation of Chameleons.
Diaz, R.E. and Trainor, P.A. (2015). BMC Evolutionary Biology 15:184-208
Captive care, raising and breeding of the Veiled Chameleon, Chamaeleo calyptratus.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.prot087718
The Veiled Chameleon, Chamaeleo calyptratus Duméril and Duméril 1851: A model for studying reptile bodyplan development and evolution.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.emo087700
Bi-modal strategy of gastrulation in Chameleon and Turtle embryos.
Stower, M. Diaz, R.E., White Crother, M. Crother, B. Marco Llorente, A., Trainor, P.A., Srinivas, S. and Bertocchini, F. (2015). Developmental Dynamics 244(9):1144-1157
Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.
Aoto, K. Sandell, L. L., Butler Tjaden, N.E, Yuen K., Noack Watt. K.E, Black, B. Durnin, M. and Trainor, P.A. (2015). Developmental Biology 402(1):3-16
The Society for Craniofacial Genetics and Developmental Biology 37th Annual Meeting.
Richtsmeier, J., Jones, M., Lozanoff, S. and Trainor, P.A. (2015). Am J Med Genet A 167(7):1455-1473
Facing up to the challenges of advancing Craniofacial Research.
Trainor, P.A. and Richtsmeier, J. (2015). Am J Med Genet A 167(7):1451-1454
Acrofacial dysostosis, Cincinnati type; a mandibulofacial dysostosis syndrome with limb anomalies caused by POLR1A dysfunction.
Weaver, K.N., Noack Watt, K.E., Hufnagel, R.B., Sund, K.L., Navajas Acedo, J., Bender, T., Hopkin, R.J., Lohmann, D.R., Trainor, P.A., Wieczorek, D. and Saal, H.M. (2015). American Journal Human Genetics 96(5):765-74
Animal models for studying neural crest development: is the mouse different?
Barriga, E.H., Trainor, P.A., Bronner, M. and Mayor, R. (2015). Development 142(9):1555-60
Ribosomopathies: Global Process, Tissue Specific Defects.
Yelick, P. and Trainor, P.A. (2015). Rare Diseases 3(1):e1025185
Cranial nerve development requires co-ordinated Shh and canonical Wnt signalling.
Hiroshi Kurosaki, H., Trainor, P.A., Leroux-Berger M. and Iulianella, A. (2015). PLOS One 10(3):e0120821
MBTPS/SKI-1/S1P protein convertase is required for ECM signaliing and axial elongation during somitogenesis and vertebral development.
Achilleos, A. Huffman, N.T., Seidah, N.G., Trainor, P.A. and Gorski J.P. (2015) Human Molecular Genetics 24(10):2884-98
Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol Vol 111 Elsevier, New York
Neural Crest Cell Evolution: How and when did a Neural Crest Cell become a Neural Crest Cell: In Neural Crest and Placodes
Munoz, W.A. and Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:3-26 Elsevier, New York
Neural Crest and Placodes – Preface. In: Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:xv-xvi . Elsevier, New York
Organogenesis Special Issue – Preface.
Trainor, P.A. and Johnson, R (2015). Developmental Dynamics 244(3):225-6
Co-ordinated brain and craniofacial development depends upon Ptch1/XIAP regulation of cell survival.
Aoto, K. and Trainor, P. A. (2015). Human Molecular Genetics 24(3):698-713
2014
Development and Evolution of the Pharyngeal Apparatus.
Frisdal, A. and Trainor, P.A. (2014). WIRES Developmental Biology wdev.147
Leucine-rich Repeat-containing G-protein Coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells during Mouse Embryonic Development.
Liu, D., Xi, C.He, Qian, P., Barker, N., Trainor, P.A., Clevers, H., Liu, H. and Li, L. (2014). Journal Biological Chemistry 289(34):23809-16
Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalling.
Callier, P., Calvel, P., Matevossian, A., Makrythanasis, P., Kurosaka, H., Thauvin-Robinet, C., Bernard, P., Borel, C., Mazaud-Guittot, S., Rolland, A., Guipponi, M., Zimmermann, C., Conne, B., Santoni, F., Vannier, A., Lambert, S., Huet, F., Mugneret, F., Jaruzelska, J., Laurence, F., Wilhelm, D., Jégou, B., Trainor, P.A., Resh, M.D., Antonarakis, S.E. and Nef S. (2014). PLOS Genetics 10(5): e1004340
Disrupting Hh and Wnt signaling interactions promotes cleft lip pathogenesis.
Kurosaka, H., Iulianella A., Williams, T. and Trainor P.A. (2014). Journal Clinical Investigation 124(4):1660-1671
Embryonic Bauplans and the Developmental Origins of Facial Diversity and Constraint.
Young, N. M., Hu, D., Lainoff, A.J., Smith, F., Diaz, R., Tucker A. S., Trainor P.A., Schneider R. S., Hallgrimsson, B. and Marcucio, R (2014) Development 141:1059-1063
Neurocristopathies: Disorders of Neural Crest Cell Development.
Noack Watt, K. and Trainor P.A. (2014). Neural Crest Cells: Evolution Development and Disease (ed Paul Trainor) Elsevier, New York.
Gene transfer techniques in whole embryo cultured post-implantation mouse embryos.
Sakai, D and Trainor, P.A. (2014). Methods Mol Biol. 1092:227-34.
Cochleovestibular nerve development is integrated with migratory neural crest cells.
Sandell, L. L., Tjaden, E. N., Barlow, A and Trainor, P.A. (2014). Developmental Biology 385(2):200–210.
2013
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
Lee, R.T.H., Nagai, H., Nakaya, Y., Sheng, G. Trainor, P.A., Weston, J.A. and Thiery, JP (2013). Development 140(24):4890-902.
The Retinaldehyde Reductase DHRS3 Is Essential for Preventing Formation of Excess Retinoic Acid During Embryonic Development.
Billings, S., Pierzchalski, K., Butler Tjaden, N.E., Pang, X., Trainor, P.A. Kane, M.A. and Moise A.R. (2013) FASEB J. 27(12):4877-89.
Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of Syngnathia.
Inman, K.E. Kume, T. and Trainor, P.A. (2013). PLoS Genetics 9(12): e1003949.
Ribosome Biogenesis in Skeletal Development and the Pathogenesis of Skeletal Disorders.
Trainor P.A. and Merrill A.E. (2014). Biochim Biophys Acta.
Facial Dysostoses: Etiology, Pathogenesis and Management.
Trainor P.A. and Andrews B.T (2013). Am J Med Genet C Semin Med Genet. 163(4):283-94.
HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
Takeda, S., Liu, H., Sasagawa, S., Dong, Y., Trainor, P.A., Cheng, E, H-Y. and Hsieh, J. J-D. (2013) Journal Clinical Investigation 123(7):3154–3165.
The Developmental Etiology and Pathogenesis of Hirschsprung Disease.
Butler, N. E. and Trainor, P.A. (2013). Translational Research 162 (1):1–15.
Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
Wynn, M.L., Rupp, P., Trainor, P.A., Schnell, S. and Kulesa, P.M. (2013). Physical Biology 10(3):035003.
Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.
Cunningham. T.J., Zhao, X., Sandell, L.L., Evans, S.M., Trainor, P.A. and Duester, G. (2013). Cell Reports 3(5):1503-11.
Molecular blueprint for craniofacial morphogenesis and development.
Trainor, P.A. (2013). In: Stem cells in craniofacial development, regeneration and repair (Huang and Thesleff eds). Wiley-Blackwell John Wiley & Sons.
Signals and switches in Mammalian neural crest cell differentiation.
Bhatt, S., Diaz, R. and Trainor, P.A. (2013). Cold Spring Harb Perspect Biol. 5(2).
Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis.
Barlow, A., Dixon, J., Dixon, M. and Trainor, P.A. (2013). Human Molecular Genetics 22(6):1206-17.
2012
Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-Induced Gene Expression during Neuronal Differentiation.
Yasukawa, T., Bhatt, S., Takeuchi, T., Kawauchi, J., Takahashi, H., Tsutusi, A., Muraoka, T., Inoue, M., Tsuda, A., Kitajima, S., Conaway, R.C., Conaway, J.W. Trainor, P.A., and Aso, T (2012). Cell Reports 2(5):1129-36.
Gadd45g and Map3k4 interactions regulate mouse testis determination via p38-mediated control of Sry expression.
Warr, N., Carre, G.-A., Siggers, P., Vitos, J., Brixey, R., Pope, M., Bogani, D., Childers, M., Wells, S., Scudamore, C., Nebreda, A.R., Trainor, P.A. and Greenfield, A. (2012). Developmental Cell 23(5):1020-31.
Wholemount nuclear fluorescent imaging: Convenient documentation of embryo morphology.
Sandell, L. L, Kurosaka, H. and Trainor, P.A. (2012). Genesis 50(11):844-50.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe craniofacial defects consistent with acrania-holoprosencephaly-agnathia.
Dennis, J.F., Kurosaka, H., Iulianella, A., Pace, J., Thomas, N., Beckham, S., Williams, T. and Trainor, P.A. (2012). PLOS Genetics 8(10):e1002927.
Neural crest stem cells: Discovery, properties and potential for therapy.
Achilleos, A., Trainor, P.A. (2012). Cell Research 22(2):288.304.
Balancing neural crest cell intrinsic processes with those of the microenvironment enable complete enteric nervous system formation.
Barlow, A.J., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). Human Molecular Genetics. 21(8):1782-1793.
RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse Embryogenesis.
Sandell, L.L., Lynn, M.L., Inman, K.E., McDowell, W., Trainor, P.A. (2012). PLoS ONE. 7(2):e30698.
Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells.
Sakai, D., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). PLoS Genetics. 8(3):e1002566.
2011
RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.
Farjo, K.M., Moiseyev, G., Nikolaeva, O., Sandell, L.L., Trainor, P.A. and Ma J-X. (2011). Developmental Biology. 357(2):347-355.
Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models.
Kumar, S., Sandell, L.L., Trainor, P.A., Koentgen, F. and Duester, G. (2012). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821(1):198-205.
Flexibility of Neural Stem Cells.
Remboutsika, E., Elkouris M., Iulianella A., Andoniadou, C., Poulou, M., Mitsiadis, T.A., Trainor, P.A. and Lovell-Badge, R. (2011). Frontiers in Physiology 2:16.
The FaceBase Consortium: A Comprehensive Program to Facilitate Craniofacial Research.
Hochheiser, H, Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita, M.L., Murray, J.C., Murray, S., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M. and Trainor, P.A. (2011). Developmental Biology 355 (2):175-182.
Rdh10 Mutants Deficient in Limb Bud Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing.
Cunningham, T.J., Chatzi, C., Sandell, L.L., Trainor, P.A., and Duester, G. (2011). Developmental Dynamics 240(5):1142-1150.
A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.
Sandell, L.L., Iulianella, A., Melton, K. Lynn, M., Walker, Inman, K., Bhatt S, Leroux-Berger, M., Crawford, M., Jones, N., Dennis., J., Trainor, P.A. (2011). Genesis 49(4):342-359.
Electroporation of Chick and Mouse Embryos.
Crull, K. E., Su, F., Swartz, M., Eberhart, J., McLennan, R., Chen, Y. and Trainor, P.A. (2011). Imaging in Developmental Biology: A Laboratory Manual. (Sharpe, Wong, Yuste eds). CSHL Press, New York.
2010
Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.
Trainor, P.A. (2010). Am J Med Genet A. 152A(12):2984-94.
Cardiac Neural crest Cells.
Inman, K.E., Ezin, M, Bronner-Fraser, M. and Trainor, P.A. (2010). Heart Development and Regeneration Volume 1:417-434. (Rosenthal and Harvey, eds), Elsevier.
Dynamic imaging of mammalian neural tube closure.
Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. (2010). Developmental Biology 344(2):941-947.
2009
Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. (2009) Development 136(14):2329-2334.
Interfering with Wnt signalling alters the periodicity of the segmentation clock.
Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. (2009) Developmental Biology 330(1):21-31.
Treacher Collins syndrome: Unmasking the role of Tcof1/treacle.
Sakai D, Trainor PA. (2009). Int J Biochem Cell Biol. 41(6):1229-1232.
Treacher Collins syndrome: etiology, pathogenesis and prevention.
Trainor PA, Dixon J, Dixon MJ. (2009). European J Human Genetics 17:275-283.
2008
Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis.
Bogni S, Trainor P, Natarajan D, Krumlauf R, Pachnis V. (2008) Development. 135(18):3007-3011.
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA. (2008) Nature Medicine 14(2):125-133.
Comments about the paper may be found in Nat Med. 2008 Feb;14(2):115-6.
Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.
Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA. (2008) Development 135(4):729-741.
2007
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. (2007) Genes and Development 21(9):1113-1124.
2006
Neural Crest Stem and Progenitor Cells.
Crane JF, Trainor PA. (2006) Annual Rev Cell Dev Biol. 22:267-286.
Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.
Dixon J, Jones NC, Sandell LL, Jayasinghe SM, Crane J, Rey JP, Dixon MJ, Trainor PA. (2006) Proc Natl Acad Sci 103(36)13403-13408.
Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O. (2006) Developmental Cell 10(3):355-366.
2005
Relations and interactions between cranial mesoderm and neural crest populations.
Noden DM, Trainor PA. (2005) J Anatomy 207(5):575-601.
2004
Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.
Kulesa P, Ellies DL, Trainor PA. (2004) Developmental Dynamics 229(1):14-29.
2003
Somitogenesis: breaking new boundaries.
Iulianella A, Melton KR, Trainor PA. (2003) Neuron 40(1):11-14.
Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia.
Iulianella A, Vanden Heuvel G, Trainor PA. (2003) Gene Expr Patterns 3(5):571-577.
Development. The bills of qucks and duails.
Trainor, PA. (2003) Science 299(5606):523-524.
2002
Riding the crest of Wnt signaling.
Trainor PA, Krumlauf R. (2002) Science 297(5582):781-783.
Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
Trainor PA, Ariza-McNaughton L, Krumlauf R. (2002) Science 295(5558):1288-1291.
Comments about this paper may be found in Nature Reviews Neuroscience 3:254
Additional comments about this paper may be found in Nature 416: 493-494.
Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.
Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R. (2002) Development 129(2):433-442.
2001
Hox genes, neural crest cells and branchial arch patterning.
Trainor PA and Krumlauf R. (2001). Curr Opin Cell Biol 13(6):698-705
Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest.
Gavalas A, Trainor PA, Ariza-McNaughton L, Krumlauf R. (2001) Development 128(15):3017-3027.
2000
Patterning cranial neural crest: roles for hindbrain segmentation and plasticity of Hox gene expression.
Trainor PA, Krumlauf R. (2000) Nature Rev Neurosci. 1(2):116-124.
Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head.
Manzanares M, Wada H, Itasaki N, Trainor PA, Krumlauf R, Holland PW. (2000) Nature 408(6814):854-857.
Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.
Manzanares M, Trainor PA, Ariza-McNaughton L, Nonchev S, Krumlauf R. (2000) Mech Dev. 94(1-2):147-156.
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.
Golding JP, Trainor PA, Krumlauf R, Gassmann M. (2000) Nature Cell Biology 2(2):103-109.
Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
Trainor PA, Krumlauf R. (2000) Nature Cell Biology 2(2):96-102
Diaz RE Jr, Shylo NA, Roellig D, Bronner M, Trainor PA. (2019) Developmental Dynamics 248(8):709-727
The transcriptome of the veiled chameleon (Chamaeleo calyptratus): A resource for studying the evolution and development of vertebrates.
Pinto BJ, Card DC, Castoe TA, Diaz RE Jr, Nielsen SV, Trainor PA, Gamble T. (2019) Developmental Dynamics 248(8):702-708
The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. (2019) Am J Med Genet A 179(5):864-869
An integrative view of Lepidosaur cranial anatomy, development and diversification.
Diaz, Jr. R.E. and Trainor, P.A. (2019). In: Heads, Jaws and Muscles Anatomical, Functional and Developmental Diversity in Chordate Evolution (Ziermann, Diaz Jr., Diogo eds). Springer.
Mouse embryo culture for the study of neural crest cells.
Munoz, W. and Trainor, P.A. (2019). In: Neural Crest Cells Methods and Protocols (Schwarz and Wiszniack eds). Methods Mol Biol. 2019;1976:107-119
2018
Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion.
Inman K.E., Caiaffa C.D., Melton K.R., Sandell L.L., Achilleos A., Kume T. and Trainor P.A. (2018) Developmental Dynamics 247(12):1286-1296
DAPI staining of whole-mount mouse embryos or fetal organs
Sandell L, Inman, K and Trainor P. (2018). Cold Spring Harbor Protocols (10):pdb.prot094029
tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis - Cincinnati type.
Noack Watt, K.E., Neben, C., Hall, S., Merrill, A.M. and Trainor, P.A. (2018). Human Molecular Genetics 27(15):2628-2643
Alterations in RA signaling affect the development of the mouse coronary vasculature.
Wang, S., Huang, W., Castillo, H.A., Kane, M.A., Xavier-Neto, J., Trainor, P.A. and Moise, A.R. (2018). Developmental Dynamics 247(8):976-991
The Society for Craniofacial Genetics and Developmental Biology 40th Annual Meeting.
Gammill, L., Cox, T., Moody, S., Taneyhill, L., Trainor, P.A. and Marcucio, R. (2018). American Journal Medical Genetics A. 176(5):1270-1273
Retinoic acid signalling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
Wang, S., Yu, J., Jones, J.W., Pierzchalski, K., Kane, M.A., Trainor, P.A., Xavier-Neto, J. and Moise, A.R. (2018). FASEB J 32(7):3765-3781
Dynamic sex chromosomes in Old World chameleons (Squamata: Chamaeleonidae).
Nielsen, S.V., Banks, J.L., Diaz Jr. R.E., Trainor, P.A. and Gamble, T. (2018). Journal of Evolutionary Biology 31(4):484-490
Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.
Iulianella, A., Sakai, D., Kurosaka, H. and Trainor, P.A. (2018). Developmental Dynamics 247(1):170-184
Developmental biology - more dynamic than ever!
Trainor, P.A. (2018). Developmental Dynamics 247(1):8-9
Neural crest cells and their application in regenerative medicine.
Trainor, P.A. (2018) In: Ten Cate's Oral Histology - Development, Structure and Function. 9th Edition p21-22. (Ed Antonio Nanci) Mosby Elsevier, St. Louis
2017
Lifting the veil on reptile embryology: the Veiled Chameleon (Chamaeleo calyptratus) as a model system to study reptilian development.
Diaz Jr, R.E., Bertocchini, F., Trainor, P.A. (2017). Methods in Molecular Biology 1650:269-284
Rdh10 loss-of-function and perturbed retinoid signalling underlies the etiology of choanal atresia.
Kurosaka, H., Wang, Q., Sandell, L.L., Yamashiro, T. and Trainor, P.A. (2017). Human Molecular Genetics 26(7): 1268-1279
New insights and changing paradigms in the regulation of vitamin A metabolism in development.
Shannon, S., and Moise, A., and Trainor, P.A. (2017). WIRES Developmental Biology wdev.264
The Society for Craniofacial Genetics and Developmental Biology 39th Annual Meeting.
Fish, J., Albertson, R.C., Harris, M., Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2017). Am J Med Genet A 173(4):985-1006
Rare syndromes of the head and face - Mandibulofacial and Acrofacial dysostoses.
Terrazas, K., Dixon, J., Trainor, P.A. and Dixon, M.J. (2017). WIRES Developmental Biology wdev.263
Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.
Amin, M. B., Miura, N., Uddin, M.K.F., Islam, M.J., Yoshida, N., Iseki, S., Kume, T., Trainor, P.A. Saitsu, H. and Aoto, K. (2017). Congenital Anomalies 57(1):24-31
2016
Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.
Sakai, D. and Trainor, P.A. (2016). Dev Growth Differ 58(7):577-85
The roles of RNA Polymerase 1 subunits Polr1c and Polr1d in craniofacial development and the pathogenesis of Treacher Collins syndrome.
Noack Watt, K.E., Achilleos, A., Neben, C., Merrill, A.M. and Trainor, P.A. (2016). PLOS Genetics 12(7):e1006187
Transcription factor TLX1 Controls Retinoic Acid Signaling to Ensure Spleen Development.
Lenti, E., Farinello, D., Yokoyama, K., Penkov, D., Castagnaro, L., Lavorgna. G., Wuputra. K., Sandel, L. L., Butler Tjaden N. E., Bernassola, F., Caridi, N., De Antoni, A., Wagner, M., Kozinc, K., Neiderreither, K., Blasi, F., Pasini, D., Majdic, G., Tonon, G., Trainor, P.A. and Brendolan, A (2016). J Clinical Investigation 126(7):2452-64
Developmental Biology: We are all Walking Mutants.
Trainor, P.A. (2016). Essays on Developmental Biology (P Wassarman: Ed) Elsevier, New York. Curr Topics Dev Biol 117:523-538
A quantitative method for defining high-arched palate using the Tcof1+/- mutant mouse as a model.
Conley, Z.R., Hague, M., Kurosaka, H., Dixon, J., Dixon, M.J and Trainor, P.A. (2016). Developmental Biology 415(2):296-305
The Society for Craniofacial Genetics and Developmental Biology 38th Annual Meeting.
Taneyhill. L., Hoover-Fong, J. Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2016). Am J Med Genet A 170(7):1732-5
Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation.
Sakai D., Dixon J., Achilleos, A., Dixon M.J. and Trainor P.A. (2016). Nature Communications 7:10328
2015
Mouse Models of Rare Craniofacial Disorders. In: Craniofacial Development (Yang Chai, editor).
Achilleos, A. and Trainor, P.A. (2015). Curr Topics Dev Biol 115:411-458. Academic Press, UK
Retinoic Acid Activity in Undifferentiated Neural Progenitors is Sufficient to Fulfil its Role in Restricting Fgf8 Expression for Somitogenesis.
Cunningham. T.J., Kumar, S., Brade, T., Sandell, L.L., Lewandoski, M., Trainor, P.A., Colas, A., Mercola, M. and Duester, G. (2015). PLOS One 10(9):e0137894
The mighty chondrocyte. No bones about it!
Purcell, P. and Trainor, P.A. (2015). J. Dental Research 94(12):1625-7
Hand/foot splitting and the "re-evolution’ of mesopodial elements during the evolution and radiation of Chameleons.
Diaz, R.E. and Trainor, P.A. (2015). BMC Evolutionary Biology 15:184-208
Captive care, raising and breeding of the Veiled Chameleon, Chamaeleo calyptratus.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.prot087718
The Veiled Chameleon, Chamaeleo calyptratus Duméril and Duméril 1851: A model for studying reptile bodyplan development and evolution.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.emo087700
Bi-modal strategy of gastrulation in Chameleon and Turtle embryos.
Stower, M. Diaz, R.E., White Crother, M. Crother, B. Marco Llorente, A., Trainor, P.A., Srinivas, S. and Bertocchini, F. (2015). Developmental Dynamics 244(9):1144-1157
Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.
Aoto, K. Sandell, L. L., Butler Tjaden, N.E, Yuen K., Noack Watt. K.E, Black, B. Durnin, M. and Trainor, P.A. (2015). Developmental Biology 402(1):3-16
The Society for Craniofacial Genetics and Developmental Biology 37th Annual Meeting.
Richtsmeier, J., Jones, M., Lozanoff, S. and Trainor, P.A. (2015). Am J Med Genet A 167(7):1455-1473
Facing up to the challenges of advancing Craniofacial Research.
Trainor, P.A. and Richtsmeier, J. (2015). Am J Med Genet A 167(7):1451-1454
Acrofacial dysostosis, Cincinnati type; a mandibulofacial dysostosis syndrome with limb anomalies caused by POLR1A dysfunction.
Weaver, K.N., Noack Watt, K.E., Hufnagel, R.B., Sund, K.L., Navajas Acedo, J., Bender, T., Hopkin, R.J., Lohmann, D.R., Trainor, P.A., Wieczorek, D. and Saal, H.M. (2015). American Journal Human Genetics 96(5):765-74
Animal models for studying neural crest development: is the mouse different?
Barriga, E.H., Trainor, P.A., Bronner, M. and Mayor, R. (2015). Development 142(9):1555-60
Ribosomopathies: Global Process, Tissue Specific Defects.
Yelick, P. and Trainor, P.A. (2015). Rare Diseases 3(1):e1025185
Cranial nerve development requires co-ordinated Shh and canonical Wnt signalling.
Hiroshi Kurosaki, H., Trainor, P.A., Leroux-Berger M. and Iulianella, A. (2015). PLOS One 10(3):e0120821
MBTPS/SKI-1/S1P protein convertase is required for ECM signaliing and axial elongation during somitogenesis and vertebral development.
Achilleos, A. Huffman, N.T., Seidah, N.G., Trainor, P.A. and Gorski J.P. (2015) Human Molecular Genetics 24(10):2884-98
Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol Vol 111 Elsevier, New York
Neural Crest Cell Evolution: How and when did a Neural Crest Cell become a Neural Crest Cell: In Neural Crest and Placodes
Munoz, W.A. and Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:3-26 Elsevier, New York
Neural Crest and Placodes – Preface. In: Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:xv-xvi . Elsevier, New York
Organogenesis Special Issue – Preface.
Trainor, P.A. and Johnson, R (2015). Developmental Dynamics 244(3):225-6
Co-ordinated brain and craniofacial development depends upon Ptch1/XIAP regulation of cell survival.
Aoto, K. and Trainor, P. A. (2015). Human Molecular Genetics 24(3):698-713
2014
Development and Evolution of the Pharyngeal Apparatus.
Frisdal, A. and Trainor, P.A. (2014). WIRES Developmental Biology wdev.147
Leucine-rich Repeat-containing G-protein Coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells during Mouse Embryonic Development.
Liu, D., Xi, C.He, Qian, P., Barker, N., Trainor, P.A., Clevers, H., Liu, H. and Li, L. (2014). Journal Biological Chemistry 289(34):23809-16
Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalling.
Callier, P., Calvel, P., Matevossian, A., Makrythanasis, P., Kurosaka, H., Thauvin-Robinet, C., Bernard, P., Borel, C., Mazaud-Guittot, S., Rolland, A., Guipponi, M., Zimmermann, C., Conne, B., Santoni, F., Vannier, A., Lambert, S., Huet, F., Mugneret, F., Jaruzelska, J., Laurence, F., Wilhelm, D., Jégou, B., Trainor, P.A., Resh, M.D., Antonarakis, S.E. and Nef S. (2014). PLOS Genetics 10(5): e1004340
Disrupting Hh and Wnt signaling interactions promotes cleft lip pathogenesis.
Kurosaka, H., Iulianella A., Williams, T. and Trainor P.A. (2014). Journal Clinical Investigation 124(4):1660-1671
Embryonic Bauplans and the Developmental Origins of Facial Diversity and Constraint.
Young, N. M., Hu, D., Lainoff, A.J., Smith, F., Diaz, R., Tucker A. S., Trainor P.A., Schneider R. S., Hallgrimsson, B. and Marcucio, R (2014) Development 141:1059-1063
Neurocristopathies: Disorders of Neural Crest Cell Development.
Noack Watt, K. and Trainor P.A. (2014). Neural Crest Cells: Evolution Development and Disease (ed Paul Trainor) Elsevier, New York.
Gene transfer techniques in whole embryo cultured post-implantation mouse embryos.
Sakai, D and Trainor, P.A. (2014). Methods Mol Biol. 1092:227-34.
Cochleovestibular nerve development is integrated with migratory neural crest cells.
Sandell, L. L., Tjaden, E. N., Barlow, A and Trainor, P.A. (2014). Developmental Biology 385(2):200–210.
2013
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
Lee, R.T.H., Nagai, H., Nakaya, Y., Sheng, G. Trainor, P.A., Weston, J.A. and Thiery, JP (2013). Development 140(24):4890-902.
The Retinaldehyde Reductase DHRS3 Is Essential for Preventing Formation of Excess Retinoic Acid During Embryonic Development.
Billings, S., Pierzchalski, K., Butler Tjaden, N.E., Pang, X., Trainor, P.A. Kane, M.A. and Moise A.R. (2013) FASEB J. 27(12):4877-89.
Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of Syngnathia.
Inman, K.E. Kume, T. and Trainor, P.A. (2013). PLoS Genetics 9(12): e1003949.
Ribosome Biogenesis in Skeletal Development and the Pathogenesis of Skeletal Disorders.
Trainor P.A. and Merrill A.E. (2014). Biochim Biophys Acta.
Facial Dysostoses: Etiology, Pathogenesis and Management.
Trainor P.A. and Andrews B.T (2013). Am J Med Genet C Semin Med Genet. 163(4):283-94.
HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
Takeda, S., Liu, H., Sasagawa, S., Dong, Y., Trainor, P.A., Cheng, E, H-Y. and Hsieh, J. J-D. (2013) Journal Clinical Investigation 123(7):3154–3165.
The Developmental Etiology and Pathogenesis of Hirschsprung Disease.
Butler, N. E. and Trainor, P.A. (2013). Translational Research 162 (1):1–15.
Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
Wynn, M.L., Rupp, P., Trainor, P.A., Schnell, S. and Kulesa, P.M. (2013). Physical Biology 10(3):035003.
Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.
Cunningham. T.J., Zhao, X., Sandell, L.L., Evans, S.M., Trainor, P.A. and Duester, G. (2013). Cell Reports 3(5):1503-11.
Molecular blueprint for craniofacial morphogenesis and development.
Trainor, P.A. (2013). In: Stem cells in craniofacial development, regeneration and repair (Huang and Thesleff eds). Wiley-Blackwell John Wiley & Sons.
Signals and switches in Mammalian neural crest cell differentiation.
Bhatt, S., Diaz, R. and Trainor, P.A. (2013). Cold Spring Harb Perspect Biol. 5(2).
Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis.
Barlow, A., Dixon, J., Dixon, M. and Trainor, P.A. (2013). Human Molecular Genetics 22(6):1206-17.
2012
Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-Induced Gene Expression during Neuronal Differentiation.
Yasukawa, T., Bhatt, S., Takeuchi, T., Kawauchi, J., Takahashi, H., Tsutusi, A., Muraoka, T., Inoue, M., Tsuda, A., Kitajima, S., Conaway, R.C., Conaway, J.W. Trainor, P.A., and Aso, T (2012). Cell Reports 2(5):1129-36.
Gadd45g and Map3k4 interactions regulate mouse testis determination via p38-mediated control of Sry expression.
Warr, N., Carre, G.-A., Siggers, P., Vitos, J., Brixey, R., Pope, M., Bogani, D., Childers, M., Wells, S., Scudamore, C., Nebreda, A.R., Trainor, P.A. and Greenfield, A. (2012). Developmental Cell 23(5):1020-31.
Wholemount nuclear fluorescent imaging: Convenient documentation of embryo morphology.
Sandell, L. L, Kurosaka, H. and Trainor, P.A. (2012). Genesis 50(11):844-50.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe craniofacial defects consistent with acrania-holoprosencephaly-agnathia.
Dennis, J.F., Kurosaka, H., Iulianella, A., Pace, J., Thomas, N., Beckham, S., Williams, T. and Trainor, P.A. (2012). PLOS Genetics 8(10):e1002927.
Neural crest stem cells: Discovery, properties and potential for therapy.
Achilleos, A., Trainor, P.A. (2012). Cell Research 22(2):288.304.
Balancing neural crest cell intrinsic processes with those of the microenvironment enable complete enteric nervous system formation.
Barlow, A.J., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). Human Molecular Genetics. 21(8):1782-1793.
RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse Embryogenesis.
Sandell, L.L., Lynn, M.L., Inman, K.E., McDowell, W., Trainor, P.A. (2012). PLoS ONE. 7(2):e30698.
Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells.
Sakai, D., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). PLoS Genetics. 8(3):e1002566.
2011
RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.
Farjo, K.M., Moiseyev, G., Nikolaeva, O., Sandell, L.L., Trainor, P.A. and Ma J-X. (2011). Developmental Biology. 357(2):347-355.
Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models.
Kumar, S., Sandell, L.L., Trainor, P.A., Koentgen, F. and Duester, G. (2012). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821(1):198-205.
Flexibility of Neural Stem Cells.
Remboutsika, E., Elkouris M., Iulianella A., Andoniadou, C., Poulou, M., Mitsiadis, T.A., Trainor, P.A. and Lovell-Badge, R. (2011). Frontiers in Physiology 2:16.
The FaceBase Consortium: A Comprehensive Program to Facilitate Craniofacial Research.
Hochheiser, H, Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita, M.L., Murray, J.C., Murray, S., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M. and Trainor, P.A. (2011). Developmental Biology 355 (2):175-182.
Rdh10 Mutants Deficient in Limb Bud Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing.
Cunningham, T.J., Chatzi, C., Sandell, L.L., Trainor, P.A., and Duester, G. (2011). Developmental Dynamics 240(5):1142-1150.
A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.
Sandell, L.L., Iulianella, A., Melton, K. Lynn, M., Walker, Inman, K., Bhatt S, Leroux-Berger, M., Crawford, M., Jones, N., Dennis., J., Trainor, P.A. (2011). Genesis 49(4):342-359.
Electroporation of Chick and Mouse Embryos.
Crull, K. E., Su, F., Swartz, M., Eberhart, J., McLennan, R., Chen, Y. and Trainor, P.A. (2011). Imaging in Developmental Biology: A Laboratory Manual. (Sharpe, Wong, Yuste eds). CSHL Press, New York.
2010
Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.
Trainor, P.A. (2010). Am J Med Genet A. 152A(12):2984-94.
Cardiac Neural crest Cells.
Inman, K.E., Ezin, M, Bronner-Fraser, M. and Trainor, P.A. (2010). Heart Development and Regeneration Volume 1:417-434. (Rosenthal and Harvey, eds), Elsevier.
Dynamic imaging of mammalian neural tube closure.
Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. (2010). Developmental Biology 344(2):941-947.
2009
Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. (2009) Development 136(14):2329-2334.
Interfering with Wnt signalling alters the periodicity of the segmentation clock.
Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. (2009) Developmental Biology 330(1):21-31.
Treacher Collins syndrome: Unmasking the role of Tcof1/treacle.
Sakai D, Trainor PA. (2009). Int J Biochem Cell Biol. 41(6):1229-1232.
Treacher Collins syndrome: etiology, pathogenesis and prevention.
Trainor PA, Dixon J, Dixon MJ. (2009). European J Human Genetics 17:275-283.
2008
Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis.
Bogni S, Trainor P, Natarajan D, Krumlauf R, Pachnis V. (2008) Development. 135(18):3007-3011.
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA. (2008) Nature Medicine 14(2):125-133.
Comments about the paper may be found in Nat Med. 2008 Feb;14(2):115-6.
Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.
Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA. (2008) Development 135(4):729-741.
2007
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. (2007) Genes and Development 21(9):1113-1124.
2006
Neural Crest Stem and Progenitor Cells.
Crane JF, Trainor PA. (2006) Annual Rev Cell Dev Biol. 22:267-286.
Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.
Dixon J, Jones NC, Sandell LL, Jayasinghe SM, Crane J, Rey JP, Dixon MJ, Trainor PA. (2006) Proc Natl Acad Sci 103(36)13403-13408.
Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O. (2006) Developmental Cell 10(3):355-366.
2005
Relations and interactions between cranial mesoderm and neural crest populations.
Noden DM, Trainor PA. (2005) J Anatomy 207(5):575-601.
2004
Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.
Kulesa P, Ellies DL, Trainor PA. (2004) Developmental Dynamics 229(1):14-29.
2003
Somitogenesis: breaking new boundaries.
Iulianella A, Melton KR, Trainor PA. (2003) Neuron 40(1):11-14.
Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia.
Iulianella A, Vanden Heuvel G, Trainor PA. (2003) Gene Expr Patterns 3(5):571-577.
Development. The bills of qucks and duails.
Trainor, PA. (2003) Science 299(5606):523-524.
2002
Riding the crest of Wnt signaling.
Trainor PA, Krumlauf R. (2002) Science 297(5582):781-783.
Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
Trainor PA, Ariza-McNaughton L, Krumlauf R. (2002) Science 295(5558):1288-1291.
Comments about this paper may be found in Nature Reviews Neuroscience 3:254
Additional comments about this paper may be found in Nature 416: 493-494.
Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.
Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R. (2002) Development 129(2):433-442.
2001
Hox genes, neural crest cells and branchial arch patterning.
Trainor PA and Krumlauf R. (2001). Curr Opin Cell Biol 13(6):698-705
Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest.
Gavalas A, Trainor PA, Ariza-McNaughton L, Krumlauf R. (2001) Development 128(15):3017-3027.
2000
Patterning cranial neural crest: roles for hindbrain segmentation and plasticity of Hox gene expression.
Trainor PA, Krumlauf R. (2000) Nature Rev Neurosci. 1(2):116-124.
Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head.
Manzanares M, Wada H, Itasaki N, Trainor PA, Krumlauf R, Holland PW. (2000) Nature 408(6814):854-857.
Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.
Manzanares M, Trainor PA, Ariza-McNaughton L, Nonchev S, Krumlauf R. (2000) Mech Dev. 94(1-2):147-156.
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.
Golding JP, Trainor PA, Krumlauf R, Gassmann M. (2000) Nature Cell Biology 2(2):103-109.
Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
Trainor PA, Krumlauf R. (2000) Nature Cell Biology 2(2):96-102
Publications
2022
2021
Acknowledging the use of human cadaveric tissues in research papers: Recommendations from anatomical journal editors.
Iwanaga J, Singh V, Ohtsuka A, Hwang Y, Kim HJ, Morys J, Ravi KS, Ribatti D, Trainor PA, Sanudo JR, Apaydin N, Sengul G, Albertine KH, Walocha JA, Loukas M, Duparc F, Paulsen F, Del Sol M, Adds P, Hegazy A, Tubbs RS. Clin Anat. 2021;34:2-4.
Iwanaga J, Singh V, Ohtsuka A, Hwang Y, Kim HJ, Morys J, Ravi KS, Ribatti D, Trainor PA, Sanudo JR, Apaydin N, Sengul G, Albertine KH, Walocha JA, Loukas M, Duparc F, Paulsen F, Del Sol M, Adds P, Hegazy A, Tubbs RS. Clin Anat. 2021;34:2-4.
Acknowledging the use of human cadaveric tissues in research papers: Recommendations from anatomical journal editors.
Iwanaga J, Singh V, Ohtsuka A, Hwang Y, Kim HJ, Morys J, Ravi KS, Ribatti D, Trainor PA, Sanudo JR, Apaydin N, Sengul G, Albertine KH, Walocha JA, Loukas M, Duparc F, Paulsen F, Del Sol M, Adds P, Hegazy A, Tubbs RS. Clin Anat. 2021;34:2-4.
Iwanaga J, Singh V, Ohtsuka A, Hwang Y, Kim HJ, Morys J, Ravi KS, Ribatti D, Trainor PA, Sanudo JR, Apaydin N, Sengul G, Albertine KH, Walocha JA, Loukas M, Duparc F, Paulsen F, Del Sol M, Adds P, Hegazy A, Tubbs RS. Clin Anat. 2021;34:2-4.
Med23 Regulates Sox9 Expression during Craniofacial Development
Dash S, Bhatt S, Falcon KT, Sandell LL, Trainor PA. 2021. J Dent Res. 100(4):406-414.2021.
Dash S, Bhatt S, Falcon KT, Sandell LL, Trainor PA. 2021. J Dent Res. 100(4):406-414.2021.
Branchiomeric Muscle Development Requires Proper Retinoic Acid Signaling.
Wang, Q, Xu L, Miura J, Saha MK, Uemura Y, Sandell LL, Trainor PA, Yamashiro T, Kurosaka H. 2021. Front Cell Dev Biol. 9:596838. doi: 10.3389/fcell.2021.596838.
Wang, Q, Xu L, Miura J, Saha MK, Uemura Y, Sandell LL, Trainor PA, Yamashiro T, Kurosaka H. 2021. Front Cell Dev Biol. 9:596838. doi: 10.3389/fcell.2021.596838.
Synergistic role of retinoic acid signaling and Gata3 during primitive choanae formation.
Kurosaka H, Mushiake J, Mithun S, Wu Y, Wang Q, Kikuchi M, Nakaya A, Yamamoto S, Inubushi T, Koga S, Sandell LL, Trainor PA, Yamashiro T. 2021. Hum Mol Genet. ddab205. doi:10.1093/hmg/ddab205.
Kurosaka H, Mushiake J, Mithun S, Wu Y, Wang Q, Kikuchi M, Nakaya A, Yamamoto S, Inubushi T, Koga S, Sandell LL, Trainor PA, Yamashiro T. 2021. Hum Mol Genet. ddab205. doi:10.1093/hmg/ddab205.
Diabetes Oxidative Stress, and DNA Damage Modulate Cranial Neural Crest Cell Development and the Phenotype Variability of Craniofacial Disorders.
Fitriasari S, Trainor PA. 2021. Front Cell Dev Biol. 9:644410. doi: 10.3389/fcell.2021.644410.
Fitriasari S, Trainor PA. 2021. Front Cell Dev Biol. 9:644410. doi: 10.3389/fcell.2021.644410.
Ocular elongation and retraction in foveated reptiles.
Rasys AM, Pau SH, Irwin KE, Luo S, Kim HQ, Wahle MA, Trainor PA, Menke DB, Lauderdale JD. 2021. Dev Dyn. 250(11):1584-1599. doi: 10.1002/dvdy.348.
Rasys AM, Pau SH, Irwin KE, Luo S, Kim HQ, Wahle MA, Trainor PA, Menke DB, Lauderdale JD. 2021. Dev Dyn. 250(11):1584-1599. doi: 10.1002/dvdy.348.
2020
The Mediator subunit, Med23 is required for embryonic survival and regulation of canonical WNT signaling during cranial ganglia development
Dash S, Bhatt S, Sandell L, Seidel C, Ahn Y, Krumlauf R, Trainor P. Front Physiol. 2020;11:531933. doi: 531910.533389/fphys.532020.531933.
Dash S, Bhatt S, Sandell L, Seidel C, Ahn Y, Krumlauf R, Trainor P. Front Physiol. 2020;11:531933. doi: 531910.533389/fphys.532020.531933.
Pak1ip1 loss-of-function leads to cell cycle arrest, loss of neural crest cells, and craniofacial abnormalities
Panoutsopoulos AA, De Crescenzo A, Lee A, Lu AM, Ross AP, Yarov-Yarovoy V, Borodinsky L, Marcucio R, Trainor P, Zarbalis K. Front Cell Dev Biol. 2020;8:510063. doi: 510010.513389/fcell.512020.510063.
Panoutsopoulos AA, De Crescenzo A, Lee A, Lu AM, Ross AP, Yarov-Yarovoy V, Borodinsky L, Marcucio R, Trainor P, Zarbalis K. Front Cell Dev Biol. 2020;8:510063. doi: 510010.513389/fcell.512020.510063.
Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis
Ono K, Sandell LL, Trainor PA, Wu DK. 2020. Development 147(15):dev192070. doi: 10.1242/dev.192070.
Ono K, Sandell LL, Trainor PA, Wu DK. 2020. Development 147(15):dev192070. doi: 10.1242/dev.192070.
37/67-laminin receptor facilitates neural crest cell migration during enteric nervous system development
Fu M, Barlow-Anacker AJ, Kuruvilla KP, Bowlin GL, Seidel CW, Trainor PA, FASEB J. 2020;34:10931–10947.
Fu M, Barlow-Anacker AJ, Kuruvilla KP, Bowlin GL, Seidel CW, Trainor PA, FASEB J. 2020;34:10931–10947.
The Society for Craniofacial Genetics and Developmental Biology 42nd Annual Meeting
Eisenhoffer GT, Jr., Clouthier D, Cox T, Saint-Jeannet JP, Taneyhill LA, Trainor PA, Moody SA. Am J Med Genet A. 2020;182:1555-1561.
Eisenhoffer GT, Jr., Clouthier D, Cox T, Saint-Jeannet JP, Taneyhill LA, Trainor PA, Moody SA. Am J Med Genet A. 2020;182:1555-1561.
Identifying vitamin A signaling by visualizing gene and protein activity, and by quantification of vitamin A metabolites
Shannon SR, Yu J, Defnet AE, Bongfeldt D, Moise AR, Kane MA, Trainor PA. Methods Enzymol. 2020;637:367-418.
Shannon SR, Yu J, Defnet AE, Bongfeldt D, Moise AR, Kane MA, Trainor PA. Methods Enzymol. 2020;637:367-418.
The development, patterning and evolution of neural crest cell differentiation into cartilage and bone.
Dash S, Trainor PA. (2020) Bone. 137:115409. doi:10.1016/j.bone.2020.11540
Dash S, Trainor PA. (2020) Bone. 137:115409. doi:10.1016/j.bone.2020.11540
Perturbed development of cranial neural crest cells in association with reduced sonic hedgehog signaling underlies the pathogenesis of retinoic-acid-induced cleft palate.
Wang Q, Kurosaka H, Kikuchi M, Nakaya A, Trainor PA, Yamashiro T. (2020) Disease Models and Mechanisms 12(10):dmm040279
Wang Q, Kurosaka H, Kikuchi M, Nakaya A, Trainor PA, Yamashiro T. (2020) Disease Models and Mechanisms 12(10):dmm040279
2019
Filling in the phylogenetic gaps: Induction, migration, and differentiation of neural crest cells in a squamate reptile, the veiled chameleon (Chamaeleo calyptratus).
Diaz RE Jr, Shylo NA, Roellig D, Bronner M, Trainor PA. (2019) Developmental Dynamics 248(8):709-727
The transcriptome of the veiled chameleon (Chamaeleo calyptratus): A resource for studying the evolution and development of vertebrates.
Pinto BJ, Card DC, Castoe TA, Diaz RE Jr, Nielsen SV, Trainor PA, Gamble T. (2019) Developmental Dynamics 248(8):702-708
The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. (2019) Am J Med Genet A 179(5):864-869
An integrative view of Lepidosaur cranial anatomy, development and diversification.
Diaz, Jr. R.E. and Trainor, P.A. (2019). In: Heads, Jaws and Muscles Anatomical, Functional and Developmental Diversity in Chordate Evolution (Ziermann, Diaz Jr., Diogo eds). Springer.
Mouse embryo culture for the study of neural crest cells.
Munoz, W. and Trainor, P.A. (2019). In: Neural Crest Cells Methods and Protocols (Schwarz and Wiszniack eds). Methods Mol Biol. 2019;1976:107-119
2018
Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion.
Inman K.E., Caiaffa C.D., Melton K.R., Sandell L.L., Achilleos A., Kume T. and Trainor P.A. (2018) Developmental Dynamics 247(12):1286-1296
DAPI staining of whole-mount mouse embryos or fetal organs
Sandell L, Inman, K and Trainor P. (2018). Cold Spring Harbor Protocols (10):pdb.prot094029
tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis - Cincinnati type.
Noack Watt, K.E., Neben, C., Hall, S., Merrill, A.M. and Trainor, P.A. (2018). Human Molecular Genetics 27(15):2628-2643
Alterations in RA signaling affect the development of the mouse coronary vasculature.
Wang, S., Huang, W., Castillo, H.A., Kane, M.A., Xavier-Neto, J., Trainor, P.A. and Moise, A.R. (2018). Developmental Dynamics 247(8):976-991
The Society for Craniofacial Genetics and Developmental Biology 40th Annual Meeting.
Gammill, L., Cox, T., Moody, S., Taneyhill, L., Trainor, P.A. and Marcucio, R. (2018). American Journal Medical Genetics A. 176(5):1270-1273
Retinoic acid signalling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
Wang, S., Yu, J., Jones, J.W., Pierzchalski, K., Kane, M.A., Trainor, P.A., Xavier-Neto, J. and Moise, A.R. (2018). FASEB J 32(7):3765-3781
Dynamic sex chromosomes in Old World chameleons (Squamata: Chamaeleonidae).
Nielsen, S.V., Banks, J.L., Diaz Jr. R.E., Trainor, P.A. and Gamble, T. (2018). Journal of Evolutionary Biology 31(4):484-490
Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.
Iulianella, A., Sakai, D., Kurosaka, H. and Trainor, P.A. (2018). Developmental Dynamics 247(1):170-184
Developmental biology - more dynamic than ever!
Trainor, P.A. (2018). Developmental Dynamics 247(1):8-9
Neural crest cells and their application in regenerative medicine.
Trainor, P.A. (2018) In: Ten Cate's Oral Histology - Development, Structure and Function. 9th Edition p21-22. (Ed Antonio Nanci) Mosby Elsevier, St. Louis
2017
Lifting the veil on reptile embryology: the Veiled Chameleon (Chamaeleo calyptratus) as a model system to study reptilian development.
Diaz Jr, R.E., Bertocchini, F., Trainor, P.A. (2017). Methods in Molecular Biology 1650:269-284
Rdh10 loss-of-function and perturbed retinoid signalling underlies the etiology of choanal atresia.
Kurosaka, H., Wang, Q., Sandell, L.L., Yamashiro, T. and Trainor, P.A. (2017). Human Molecular Genetics 26(7): 1268-1279
New insights and changing paradigms in the regulation of vitamin A metabolism in development.
Shannon, S., and Moise, A., and Trainor, P.A. (2017). WIRES Developmental Biology wdev.264
The Society for Craniofacial Genetics and Developmental Biology 39th Annual Meeting.
Fish, J., Albertson, R.C., Harris, M., Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2017). Am J Med Genet A 173(4):985-1006
Rare syndromes of the head and face - Mandibulofacial and Acrofacial dysostoses.
Terrazas, K., Dixon, J., Trainor, P.A. and Dixon, M.J. (2017). WIRES Developmental Biology wdev.263
Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.
Amin, M. B., Miura, N., Uddin, M.K.F., Islam, M.J., Yoshida, N., Iseki, S., Kume, T., Trainor, P.A. Saitsu, H. and Aoto, K. (2017). Congenital Anomalies 57(1):24-31
2016
Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.
Sakai, D. and Trainor, P.A. (2016). Dev Growth Differ 58(7):577-85
The roles of RNA Polymerase 1 subunits Polr1c and Polr1d in craniofacial development and the pathogenesis of Treacher Collins syndrome.
Noack Watt, K.E., Achilleos, A., Neben, C., Merrill, A.M. and Trainor, P.A. (2016). PLOS Genetics 12(7):e1006187
Transcription factor TLX1 Controls Retinoic Acid Signaling to Ensure Spleen Development.
Lenti, E., Farinello, D., Yokoyama, K., Penkov, D., Castagnaro, L., Lavorgna. G., Wuputra. K., Sandel, L. L., Butler Tjaden N. E., Bernassola, F., Caridi, N., De Antoni, A., Wagner, M., Kozinc, K., Neiderreither, K., Blasi, F., Pasini, D., Majdic, G., Tonon, G., Trainor, P.A. and Brendolan, A (2016). J Clinical Investigation 126(7):2452-64
Developmental Biology: We are all Walking Mutants.
Trainor, P.A. (2016). Essays on Developmental Biology (P Wassarman: Ed) Elsevier, New York. Curr Topics Dev Biol 117:523-538
A quantitative method for defining high-arched palate using the Tcof1+/- mutant mouse as a model.
Conley, Z.R., Hague, M., Kurosaka, H., Dixon, J., Dixon, M.J and Trainor, P.A. (2016). Developmental Biology 415(2):296-305
The Society for Craniofacial Genetics and Developmental Biology 38th Annual Meeting.
Taneyhill. L., Hoover-Fong, J. Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2016). Am J Med Genet A 170(7):1732-5
Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation.
Sakai D., Dixon J., Achilleos, A., Dixon M.J. and Trainor P.A. (2016). Nature Communications 7:10328
2015
Mouse Models of Rare Craniofacial Disorders. In: Craniofacial Development (Yang Chai, editor).
Achilleos, A. and Trainor, P.A. (2015). Curr Topics Dev Biol 115:411-458. Academic Press, UK
Retinoic Acid Activity in Undifferentiated Neural Progenitors is Sufficient to Fulfil its Role in Restricting Fgf8 Expression for Somitogenesis.
Cunningham. T.J., Kumar, S., Brade, T., Sandell, L.L., Lewandoski, M., Trainor, P.A., Colas, A., Mercola, M. and Duester, G. (2015). PLOS One 10(9):e0137894
The mighty chondrocyte. No bones about it!
Purcell, P. and Trainor, P.A. (2015). J. Dental Research 94(12):1625-7
Hand/foot splitting and the "re-evolution’ of mesopodial elements during the evolution and radiation of Chameleons.
Diaz, R.E. and Trainor, P.A. (2015). BMC Evolutionary Biology 15:184-208
Captive care, raising and breeding of the Veiled Chameleon, Chamaeleo calyptratus.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.prot087718
The Veiled Chameleon, Chamaeleo calyptratus Duméril and Duméril 1851: A model for studying reptile bodyplan development and evolution.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.emo087700
Bi-modal strategy of gastrulation in Chameleon and Turtle embryos.
Stower, M. Diaz, R.E., White Crother, M. Crother, B. Marco Llorente, A., Trainor, P.A., Srinivas, S. and Bertocchini, F. (2015). Developmental Dynamics 244(9):1144-1157
Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.
Aoto, K. Sandell, L. L., Butler Tjaden, N.E, Yuen K., Noack Watt. K.E, Black, B. Durnin, M. and Trainor, P.A. (2015). Developmental Biology 402(1):3-16
The Society for Craniofacial Genetics and Developmental Biology 37th Annual Meeting.
Richtsmeier, J., Jones, M., Lozanoff, S. and Trainor, P.A. (2015). Am J Med Genet A 167(7):1455-1473
Facing up to the challenges of advancing Craniofacial Research.
Trainor, P.A. and Richtsmeier, J. (2015). Am J Med Genet A 167(7):1451-1454
Acrofacial dysostosis, Cincinnati type; a mandibulofacial dysostosis syndrome with limb anomalies caused by POLR1A dysfunction.
Weaver, K.N., Noack Watt, K.E., Hufnagel, R.B., Sund, K.L., Navajas Acedo, J., Bender, T., Hopkin, R.J., Lohmann, D.R., Trainor, P.A., Wieczorek, D. and Saal, H.M. (2015). American Journal Human Genetics 96(5):765-74
Animal models for studying neural crest development: is the mouse different?
Barriga, E.H., Trainor, P.A., Bronner, M. and Mayor, R. (2015). Development 142(9):1555-60
Ribosomopathies: Global Process, Tissue Specific Defects.
Yelick, P. and Trainor, P.A. (2015). Rare Diseases 3(1):e1025185
Cranial nerve development requires co-ordinated Shh and canonical Wnt signalling.
Hiroshi Kurosaki, H., Trainor, P.A., Leroux-Berger M. and Iulianella, A. (2015). PLOS One 10(3):e0120821
MBTPS/SKI-1/S1P protein convertase is required for ECM signaliing and axial elongation during somitogenesis and vertebral development.
Achilleos, A. Huffman, N.T., Seidah, N.G., Trainor, P.A. and Gorski J.P. (2015) Human Molecular Genetics 24(10):2884-98
Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol Vol 111 Elsevier, New York
Neural Crest Cell Evolution: How and when did a Neural Crest Cell become a Neural Crest Cell: In Neural Crest and Placodes
Munoz, W.A. and Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:3-26 Elsevier, New York
Neural Crest and Placodes – Preface. In: Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:xv-xvi . Elsevier, New York
Organogenesis Special Issue – Preface.
Trainor, P.A. and Johnson, R (2015). Developmental Dynamics 244(3):225-6
Co-ordinated brain and craniofacial development depends upon Ptch1/XIAP regulation of cell survival.
Aoto, K. and Trainor, P. A. (2015). Human Molecular Genetics 24(3):698-713
2014
Development and Evolution of the Pharyngeal Apparatus.
Frisdal, A. and Trainor, P.A. (2014). WIRES Developmental Biology wdev.147
Leucine-rich Repeat-containing G-protein Coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells during Mouse Embryonic Development.
Liu, D., Xi, C.He, Qian, P., Barker, N., Trainor, P.A., Clevers, H., Liu, H. and Li, L. (2014). Journal Biological Chemistry 289(34):23809-16
Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalling.
Callier, P., Calvel, P., Matevossian, A., Makrythanasis, P., Kurosaka, H., Thauvin-Robinet, C., Bernard, P., Borel, C., Mazaud-Guittot, S., Rolland, A., Guipponi, M., Zimmermann, C., Conne, B., Santoni, F., Vannier, A., Lambert, S., Huet, F., Mugneret, F., Jaruzelska, J., Laurence, F., Wilhelm, D., Jégou, B., Trainor, P.A., Resh, M.D., Antonarakis, S.E. and Nef S. (2014). PLOS Genetics 10(5): e1004340
Disrupting Hh and Wnt signaling interactions promotes cleft lip pathogenesis.
Kurosaka, H., Iulianella A., Williams, T. and Trainor P.A. (2014). Journal Clinical Investigation 124(4):1660-1671
Embryonic Bauplans and the Developmental Origins of Facial Diversity and Constraint.
Young, N. M., Hu, D., Lainoff, A.J., Smith, F., Diaz, R., Tucker A. S., Trainor P.A., Schneider R. S., Hallgrimsson, B. and Marcucio, R (2014) Development 141:1059-1063
Neurocristopathies: Disorders of Neural Crest Cell Development.
Noack Watt, K. and Trainor P.A. (2014). Neural Crest Cells: Evolution Development and Disease (ed Paul Trainor) Elsevier, New York.
Gene transfer techniques in whole embryo cultured post-implantation mouse embryos.
Sakai, D and Trainor, P.A. (2014). Methods Mol Biol. 1092:227-34.
Cochleovestibular nerve development is integrated with migratory neural crest cells.
Sandell, L. L., Tjaden, E. N., Barlow, A and Trainor, P.A. (2014). Developmental Biology 385(2):200–210.
2013
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
Lee, R.T.H., Nagai, H., Nakaya, Y., Sheng, G. Trainor, P.A., Weston, J.A. and Thiery, JP (2013). Development 140(24):4890-902.
The Retinaldehyde Reductase DHRS3 Is Essential for Preventing Formation of Excess Retinoic Acid During Embryonic Development.
Billings, S., Pierzchalski, K., Butler Tjaden, N.E., Pang, X., Trainor, P.A. Kane, M.A. and Moise A.R. (2013) FASEB J. 27(12):4877-89.
Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of Syngnathia.
Inman, K.E. Kume, T. and Trainor, P.A. (2013). PLoS Genetics 9(12): e1003949.
Ribosome Biogenesis in Skeletal Development and the Pathogenesis of Skeletal Disorders.
Trainor P.A. and Merrill A.E. (2014). Biochim Biophys Acta.
Facial Dysostoses: Etiology, Pathogenesis and Management.
Trainor P.A. and Andrews B.T (2013). Am J Med Genet C Semin Med Genet. 163(4):283-94.
HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
Takeda, S., Liu, H., Sasagawa, S., Dong, Y., Trainor, P.A., Cheng, E, H-Y. and Hsieh, J. J-D. (2013) Journal Clinical Investigation 123(7):3154–3165.
The Developmental Etiology and Pathogenesis of Hirschsprung Disease.
Butler, N. E. and Trainor, P.A. (2013). Translational Research 162 (1):1–15.
Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
Wynn, M.L., Rupp, P., Trainor, P.A., Schnell, S. and Kulesa, P.M. (2013). Physical Biology 10(3):035003.
Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.
Cunningham. T.J., Zhao, X., Sandell, L.L., Evans, S.M., Trainor, P.A. and Duester, G. (2013). Cell Reports 3(5):1503-11.
Molecular blueprint for craniofacial morphogenesis and development.
Trainor, P.A. (2013). In: Stem cells in craniofacial development, regeneration and repair (Huang and Thesleff eds). Wiley-Blackwell John Wiley & Sons.
Signals and switches in Mammalian neural crest cell differentiation.
Bhatt, S., Diaz, R. and Trainor, P.A. (2013). Cold Spring Harb Perspect Biol. 5(2).
Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis.
Barlow, A., Dixon, J., Dixon, M. and Trainor, P.A. (2013). Human Molecular Genetics 22(6):1206-17.
2012
Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-Induced Gene Expression during Neuronal Differentiation.
Yasukawa, T., Bhatt, S., Takeuchi, T., Kawauchi, J., Takahashi, H., Tsutusi, A., Muraoka, T., Inoue, M., Tsuda, A., Kitajima, S., Conaway, R.C., Conaway, J.W. Trainor, P.A., and Aso, T (2012). Cell Reports 2(5):1129-36.
Gadd45g and Map3k4 interactions regulate mouse testis determination via p38-mediated control of Sry expression.
Warr, N., Carre, G.-A., Siggers, P., Vitos, J., Brixey, R., Pope, M., Bogani, D., Childers, M., Wells, S., Scudamore, C., Nebreda, A.R., Trainor, P.A. and Greenfield, A. (2012). Developmental Cell 23(5):1020-31.
Wholemount nuclear fluorescent imaging: Convenient documentation of embryo morphology.
Sandell, L. L, Kurosaka, H. and Trainor, P.A. (2012). Genesis 50(11):844-50.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe craniofacial defects consistent with acrania-holoprosencephaly-agnathia.
Dennis, J.F., Kurosaka, H., Iulianella, A., Pace, J., Thomas, N., Beckham, S., Williams, T. and Trainor, P.A. (2012). PLOS Genetics 8(10):e1002927.
Neural crest stem cells: Discovery, properties and potential for therapy.
Achilleos, A., Trainor, P.A. (2012). Cell Research 22(2):288.304.
Balancing neural crest cell intrinsic processes with those of the microenvironment enable complete enteric nervous system formation.
Barlow, A.J., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). Human Molecular Genetics. 21(8):1782-1793.
RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse Embryogenesis.
Sandell, L.L., Lynn, M.L., Inman, K.E., McDowell, W., Trainor, P.A. (2012). PLoS ONE. 7(2):e30698.
Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells.
Sakai, D., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). PLoS Genetics. 8(3):e1002566.
2011
RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.
Farjo, K.M., Moiseyev, G., Nikolaeva, O., Sandell, L.L., Trainor, P.A. and Ma J-X. (2011). Developmental Biology. 357(2):347-355.
Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models.
Kumar, S., Sandell, L.L., Trainor, P.A., Koentgen, F. and Duester, G. (2012). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821(1):198-205.
Flexibility of Neural Stem Cells.
Remboutsika, E., Elkouris M., Iulianella A., Andoniadou, C., Poulou, M., Mitsiadis, T.A., Trainor, P.A. and Lovell-Badge, R. (2011). Frontiers in Physiology 2:16.
The FaceBase Consortium: A Comprehensive Program to Facilitate Craniofacial Research.
Hochheiser, H, Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita, M.L., Murray, J.C., Murray, S., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M. and Trainor, P.A. (2011). Developmental Biology 355 (2):175-182.
Rdh10 Mutants Deficient in Limb Bud Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing.
Cunningham, T.J., Chatzi, C., Sandell, L.L., Trainor, P.A., and Duester, G. (2011). Developmental Dynamics 240(5):1142-1150.
A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.
Sandell, L.L., Iulianella, A., Melton, K. Lynn, M., Walker, Inman, K., Bhatt S, Leroux-Berger, M., Crawford, M., Jones, N., Dennis., J., Trainor, P.A. (2011). Genesis 49(4):342-359.
Electroporation of Chick and Mouse Embryos.
Crull, K. E., Su, F., Swartz, M., Eberhart, J., McLennan, R., Chen, Y. and Trainor, P.A. (2011). Imaging in Developmental Biology: A Laboratory Manual. (Sharpe, Wong, Yuste eds). CSHL Press, New York.
2010
Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.
Trainor, P.A. (2010). Am J Med Genet A. 152A(12):2984-94.
Cardiac Neural crest Cells.
Inman, K.E., Ezin, M, Bronner-Fraser, M. and Trainor, P.A. (2010). Heart Development and Regeneration Volume 1:417-434. (Rosenthal and Harvey, eds), Elsevier.
Dynamic imaging of mammalian neural tube closure.
Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. (2010). Developmental Biology 344(2):941-947.
2009
Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. (2009) Development 136(14):2329-2334.
Interfering with Wnt signalling alters the periodicity of the segmentation clock.
Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. (2009) Developmental Biology 330(1):21-31.
Treacher Collins syndrome: Unmasking the role of Tcof1/treacle.
Sakai D, Trainor PA. (2009). Int J Biochem Cell Biol. 41(6):1229-1232.
Treacher Collins syndrome: etiology, pathogenesis and prevention.
Trainor PA, Dixon J, Dixon MJ. (2009). European J Human Genetics 17:275-283.
2008
Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis.
Bogni S, Trainor P, Natarajan D, Krumlauf R, Pachnis V. (2008) Development. 135(18):3007-3011.
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA. (2008) Nature Medicine 14(2):125-133.
Comments about the paper may be found in Nat Med. 2008 Feb;14(2):115-6.
Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.
Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA. (2008) Development 135(4):729-741.
2007
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. (2007) Genes and Development 21(9):1113-1124.
2006
Neural Crest Stem and Progenitor Cells.
Crane JF, Trainor PA. (2006) Annual Rev Cell Dev Biol. 22:267-286.
Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.
Dixon J, Jones NC, Sandell LL, Jayasinghe SM, Crane J, Rey JP, Dixon MJ, Trainor PA. (2006) Proc Natl Acad Sci 103(36)13403-13408.
Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O. (2006) Developmental Cell 10(3):355-366.
2005
Relations and interactions between cranial mesoderm and neural crest populations.
Noden DM, Trainor PA. (2005) J Anatomy 207(5):575-601.
2004
Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.
Kulesa P, Ellies DL, Trainor PA. (2004) Developmental Dynamics 229(1):14-29.
2003
Somitogenesis: breaking new boundaries.
Iulianella A, Melton KR, Trainor PA. (2003) Neuron 40(1):11-14.
Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia.
Iulianella A, Vanden Heuvel G, Trainor PA. (2003) Gene Expr Patterns 3(5):571-577.
Development. The bills of qucks and duails.
Trainor, PA. (2003) Science 299(5606):523-524.
2002
Riding the crest of Wnt signaling.
Trainor PA, Krumlauf R. (2002) Science 297(5582):781-783.
Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
Trainor PA, Ariza-McNaughton L, Krumlauf R. (2002) Science 295(5558):1288-1291.
Comments about this paper may be found in Nature Reviews Neuroscience 3:254
Additional comments about this paper may be found in Nature 416: 493-494.
Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.
Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R. (2002) Development 129(2):433-442.
2001
Hox genes, neural crest cells and branchial arch patterning.
Trainor PA and Krumlauf R. (2001). Curr Opin Cell Biol 13(6):698-705
Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest.
Gavalas A, Trainor PA, Ariza-McNaughton L, Krumlauf R. (2001) Development 128(15):3017-3027.
2000
Patterning cranial neural crest: roles for hindbrain segmentation and plasticity of Hox gene expression.
Trainor PA, Krumlauf R. (2000) Nature Rev Neurosci. 1(2):116-124.
Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head.
Manzanares M, Wada H, Itasaki N, Trainor PA, Krumlauf R, Holland PW. (2000) Nature 408(6814):854-857.
Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.
Manzanares M, Trainor PA, Ariza-McNaughton L, Nonchev S, Krumlauf R. (2000) Mech Dev. 94(1-2):147-156.
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.
Golding JP, Trainor PA, Krumlauf R, Gassmann M. (2000) Nature Cell Biology 2(2):103-109.
Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
Trainor PA, Krumlauf R. (2000) Nature Cell Biology 2(2):96-102
Diaz RE Jr, Shylo NA, Roellig D, Bronner M, Trainor PA. (2019) Developmental Dynamics 248(8):709-727
The transcriptome of the veiled chameleon (Chamaeleo calyptratus): A resource for studying the evolution and development of vertebrates.
Pinto BJ, Card DC, Castoe TA, Diaz RE Jr, Nielsen SV, Trainor PA, Gamble T. (2019) Developmental Dynamics 248(8):702-708
The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. (2019) Am J Med Genet A 179(5):864-869
An integrative view of Lepidosaur cranial anatomy, development and diversification.
Diaz, Jr. R.E. and Trainor, P.A. (2019). In: Heads, Jaws and Muscles Anatomical, Functional and Developmental Diversity in Chordate Evolution (Ziermann, Diaz Jr., Diogo eds). Springer.
Mouse embryo culture for the study of neural crest cells.
Munoz, W. and Trainor, P.A. (2019). In: Neural Crest Cells Methods and Protocols (Schwarz and Wiszniack eds). Methods Mol Biol. 2019;1976:107-119
2018
Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion.
Inman K.E., Caiaffa C.D., Melton K.R., Sandell L.L., Achilleos A., Kume T. and Trainor P.A. (2018) Developmental Dynamics 247(12):1286-1296
DAPI staining of whole-mount mouse embryos or fetal organs
Sandell L, Inman, K and Trainor P. (2018). Cold Spring Harbor Protocols (10):pdb.prot094029
tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis - Cincinnati type.
Noack Watt, K.E., Neben, C., Hall, S., Merrill, A.M. and Trainor, P.A. (2018). Human Molecular Genetics 27(15):2628-2643
Alterations in RA signaling affect the development of the mouse coronary vasculature.
Wang, S., Huang, W., Castillo, H.A., Kane, M.A., Xavier-Neto, J., Trainor, P.A. and Moise, A.R. (2018). Developmental Dynamics 247(8):976-991
The Society for Craniofacial Genetics and Developmental Biology 40th Annual Meeting.
Gammill, L., Cox, T., Moody, S., Taneyhill, L., Trainor, P.A. and Marcucio, R. (2018). American Journal Medical Genetics A. 176(5):1270-1273
Retinoic acid signalling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
Wang, S., Yu, J., Jones, J.W., Pierzchalski, K., Kane, M.A., Trainor, P.A., Xavier-Neto, J. and Moise, A.R. (2018). FASEB J 32(7):3765-3781
Dynamic sex chromosomes in Old World chameleons (Squamata: Chamaeleonidae).
Nielsen, S.V., Banks, J.L., Diaz Jr. R.E., Trainor, P.A. and Gamble, T. (2018). Journal of Evolutionary Biology 31(4):484-490
Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.
Iulianella, A., Sakai, D., Kurosaka, H. and Trainor, P.A. (2018). Developmental Dynamics 247(1):170-184
Developmental biology - more dynamic than ever!
Trainor, P.A. (2018). Developmental Dynamics 247(1):8-9
Neural crest cells and their application in regenerative medicine.
Trainor, P.A. (2018) In: Ten Cate's Oral Histology - Development, Structure and Function. 9th Edition p21-22. (Ed Antonio Nanci) Mosby Elsevier, St. Louis
2017
Lifting the veil on reptile embryology: the Veiled Chameleon (Chamaeleo calyptratus) as a model system to study reptilian development.
Diaz Jr, R.E., Bertocchini, F., Trainor, P.A. (2017). Methods in Molecular Biology 1650:269-284
Rdh10 loss-of-function and perturbed retinoid signalling underlies the etiology of choanal atresia.
Kurosaka, H., Wang, Q., Sandell, L.L., Yamashiro, T. and Trainor, P.A. (2017). Human Molecular Genetics 26(7): 1268-1279
New insights and changing paradigms in the regulation of vitamin A metabolism in development.
Shannon, S., and Moise, A., and Trainor, P.A. (2017). WIRES Developmental Biology wdev.264
The Society for Craniofacial Genetics and Developmental Biology 39th Annual Meeting.
Fish, J., Albertson, R.C., Harris, M., Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2017). Am J Med Genet A 173(4):985-1006
Rare syndromes of the head and face - Mandibulofacial and Acrofacial dysostoses.
Terrazas, K., Dixon, J., Trainor, P.A. and Dixon, M.J. (2017). WIRES Developmental Biology wdev.263
Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.
Amin, M. B., Miura, N., Uddin, M.K.F., Islam, M.J., Yoshida, N., Iseki, S., Kume, T., Trainor, P.A. Saitsu, H. and Aoto, K. (2017). Congenital Anomalies 57(1):24-31
2016
Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.
Sakai, D. and Trainor, P.A. (2016). Dev Growth Differ 58(7):577-85
The roles of RNA Polymerase 1 subunits Polr1c and Polr1d in craniofacial development and the pathogenesis of Treacher Collins syndrome.
Noack Watt, K.E., Achilleos, A., Neben, C., Merrill, A.M. and Trainor, P.A. (2016). PLOS Genetics 12(7):e1006187
Transcription factor TLX1 Controls Retinoic Acid Signaling to Ensure Spleen Development.
Lenti, E., Farinello, D., Yokoyama, K., Penkov, D., Castagnaro, L., Lavorgna. G., Wuputra. K., Sandel, L. L., Butler Tjaden N. E., Bernassola, F., Caridi, N., De Antoni, A., Wagner, M., Kozinc, K., Neiderreither, K., Blasi, F., Pasini, D., Majdic, G., Tonon, G., Trainor, P.A. and Brendolan, A (2016). J Clinical Investigation 126(7):2452-64
Developmental Biology: We are all Walking Mutants.
Trainor, P.A. (2016). Essays on Developmental Biology (P Wassarman: Ed) Elsevier, New York. Curr Topics Dev Biol 117:523-538
A quantitative method for defining high-arched palate using the Tcof1+/- mutant mouse as a model.
Conley, Z.R., Hague, M., Kurosaka, H., Dixon, J., Dixon, M.J and Trainor, P.A. (2016). Developmental Biology 415(2):296-305
The Society for Craniofacial Genetics and Developmental Biology 38th Annual Meeting.
Taneyhill. L., Hoover-Fong, J. Lozanoff, S., Marcucio, R., Richtsmeier, J. and Trainor, P.A. (2016). Am J Med Genet A 170(7):1732-5
Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation.
Sakai D., Dixon J., Achilleos, A., Dixon M.J. and Trainor P.A. (2016). Nature Communications 7:10328
2015
Mouse Models of Rare Craniofacial Disorders. In: Craniofacial Development (Yang Chai, editor).
Achilleos, A. and Trainor, P.A. (2015). Curr Topics Dev Biol 115:411-458. Academic Press, UK
Retinoic Acid Activity in Undifferentiated Neural Progenitors is Sufficient to Fulfil its Role in Restricting Fgf8 Expression for Somitogenesis.
Cunningham. T.J., Kumar, S., Brade, T., Sandell, L.L., Lewandoski, M., Trainor, P.A., Colas, A., Mercola, M. and Duester, G. (2015). PLOS One 10(9):e0137894
The mighty chondrocyte. No bones about it!
Purcell, P. and Trainor, P.A. (2015). J. Dental Research 94(12):1625-7
Hand/foot splitting and the "re-evolution’ of mesopodial elements during the evolution and radiation of Chameleons.
Diaz, R.E. and Trainor, P.A. (2015). BMC Evolutionary Biology 15:184-208
Captive care, raising and breeding of the Veiled Chameleon, Chamaeleo calyptratus.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.prot087718
The Veiled Chameleon, Chamaeleo calyptratus Duméril and Duméril 1851: A model for studying reptile bodyplan development and evolution.
Diaz, R. E., Anderson, C.V. Baumann, D. Jewell, D., Kupronis, R., Piraquive, C., Schieszer. J., Winter, K. and Trainor, P.A. (2015). Cold Spring Harbor Protocols (10):pdb.emo087700
Bi-modal strategy of gastrulation in Chameleon and Turtle embryos.
Stower, M. Diaz, R.E., White Crother, M. Crother, B. Marco Llorente, A., Trainor, P.A., Srinivas, S. and Bertocchini, F. (2015). Developmental Dynamics 244(9):1144-1157
Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.
Aoto, K. Sandell, L. L., Butler Tjaden, N.E, Yuen K., Noack Watt. K.E, Black, B. Durnin, M. and Trainor, P.A. (2015). Developmental Biology 402(1):3-16
The Society for Craniofacial Genetics and Developmental Biology 37th Annual Meeting.
Richtsmeier, J., Jones, M., Lozanoff, S. and Trainor, P.A. (2015). Am J Med Genet A 167(7):1455-1473
Facing up to the challenges of advancing Craniofacial Research.
Trainor, P.A. and Richtsmeier, J. (2015). Am J Med Genet A 167(7):1451-1454
Acrofacial dysostosis, Cincinnati type; a mandibulofacial dysostosis syndrome with limb anomalies caused by POLR1A dysfunction.
Weaver, K.N., Noack Watt, K.E., Hufnagel, R.B., Sund, K.L., Navajas Acedo, J., Bender, T., Hopkin, R.J., Lohmann, D.R., Trainor, P.A., Wieczorek, D. and Saal, H.M. (2015). American Journal Human Genetics 96(5):765-74
Animal models for studying neural crest development: is the mouse different?
Barriga, E.H., Trainor, P.A., Bronner, M. and Mayor, R. (2015). Development 142(9):1555-60
Ribosomopathies: Global Process, Tissue Specific Defects.
Yelick, P. and Trainor, P.A. (2015). Rare Diseases 3(1):e1025185
Cranial nerve development requires co-ordinated Shh and canonical Wnt signalling.
Hiroshi Kurosaki, H., Trainor, P.A., Leroux-Berger M. and Iulianella, A. (2015). PLOS One 10(3):e0120821
MBTPS/SKI-1/S1P protein convertase is required for ECM signaliing and axial elongation during somitogenesis and vertebral development.
Achilleos, A. Huffman, N.T., Seidah, N.G., Trainor, P.A. and Gorski J.P. (2015) Human Molecular Genetics 24(10):2884-98
Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol Vol 111 Elsevier, New York
Neural Crest Cell Evolution: How and when did a Neural Crest Cell become a Neural Crest Cell: In Neural Crest and Placodes
Munoz, W.A. and Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:3-26 Elsevier, New York
Neural Crest and Placodes – Preface. In: Neural Crest and Placodes
Trainor, P.A. (2015). (P.A.Trainor: Ed). Curr Top Dev Biol 111:xv-xvi . Elsevier, New York
Organogenesis Special Issue – Preface.
Trainor, P.A. and Johnson, R (2015). Developmental Dynamics 244(3):225-6
Co-ordinated brain and craniofacial development depends upon Ptch1/XIAP regulation of cell survival.
Aoto, K. and Trainor, P. A. (2015). Human Molecular Genetics 24(3):698-713
2014
Development and Evolution of the Pharyngeal Apparatus.
Frisdal, A. and Trainor, P.A. (2014). WIRES Developmental Biology wdev.147
Leucine-rich Repeat-containing G-protein Coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells during Mouse Embryonic Development.
Liu, D., Xi, C.He, Qian, P., Barker, N., Trainor, P.A., Clevers, H., Liu, H. and Li, L. (2014). Journal Biological Chemistry 289(34):23809-16
Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalling.
Callier, P., Calvel, P., Matevossian, A., Makrythanasis, P., Kurosaka, H., Thauvin-Robinet, C., Bernard, P., Borel, C., Mazaud-Guittot, S., Rolland, A., Guipponi, M., Zimmermann, C., Conne, B., Santoni, F., Vannier, A., Lambert, S., Huet, F., Mugneret, F., Jaruzelska, J., Laurence, F., Wilhelm, D., Jégou, B., Trainor, P.A., Resh, M.D., Antonarakis, S.E. and Nef S. (2014). PLOS Genetics 10(5): e1004340
Disrupting Hh and Wnt signaling interactions promotes cleft lip pathogenesis.
Kurosaka, H., Iulianella A., Williams, T. and Trainor P.A. (2014). Journal Clinical Investigation 124(4):1660-1671
Embryonic Bauplans and the Developmental Origins of Facial Diversity and Constraint.
Young, N. M., Hu, D., Lainoff, A.J., Smith, F., Diaz, R., Tucker A. S., Trainor P.A., Schneider R. S., Hallgrimsson, B. and Marcucio, R (2014) Development 141:1059-1063
Neurocristopathies: Disorders of Neural Crest Cell Development.
Noack Watt, K. and Trainor P.A. (2014). Neural Crest Cells: Evolution Development and Disease (ed Paul Trainor) Elsevier, New York.
Gene transfer techniques in whole embryo cultured post-implantation mouse embryos.
Sakai, D and Trainor, P.A. (2014). Methods Mol Biol. 1092:227-34.
Cochleovestibular nerve development is integrated with migratory neural crest cells.
Sandell, L. L., Tjaden, E. N., Barlow, A and Trainor, P.A. (2014). Developmental Biology 385(2):200–210.
2013
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
Lee, R.T.H., Nagai, H., Nakaya, Y., Sheng, G. Trainor, P.A., Weston, J.A. and Thiery, JP (2013). Development 140(24):4890-902.
The Retinaldehyde Reductase DHRS3 Is Essential for Preventing Formation of Excess Retinoic Acid During Embryonic Development.
Billings, S., Pierzchalski, K., Butler Tjaden, N.E., Pang, X., Trainor, P.A. Kane, M.A. and Moise A.R. (2013) FASEB J. 27(12):4877-89.
Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of Syngnathia.
Inman, K.E. Kume, T. and Trainor, P.A. (2013). PLoS Genetics 9(12): e1003949.
Ribosome Biogenesis in Skeletal Development and the Pathogenesis of Skeletal Disorders.
Trainor P.A. and Merrill A.E. (2014). Biochim Biophys Acta.
Facial Dysostoses: Etiology, Pathogenesis and Management.
Trainor P.A. and Andrews B.T (2013). Am J Med Genet C Semin Med Genet. 163(4):283-94.
HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
Takeda, S., Liu, H., Sasagawa, S., Dong, Y., Trainor, P.A., Cheng, E, H-Y. and Hsieh, J. J-D. (2013) Journal Clinical Investigation 123(7):3154–3165.
The Developmental Etiology and Pathogenesis of Hirschsprung Disease.
Butler, N. E. and Trainor, P.A. (2013). Translational Research 162 (1):1–15.
Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
Wynn, M.L., Rupp, P., Trainor, P.A., Schnell, S. and Kulesa, P.M. (2013). Physical Biology 10(3):035003.
Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.
Cunningham. T.J., Zhao, X., Sandell, L.L., Evans, S.M., Trainor, P.A. and Duester, G. (2013). Cell Reports 3(5):1503-11.
Molecular blueprint for craniofacial morphogenesis and development.
Trainor, P.A. (2013). In: Stem cells in craniofacial development, regeneration and repair (Huang and Thesleff eds). Wiley-Blackwell John Wiley & Sons.
Signals and switches in Mammalian neural crest cell differentiation.
Bhatt, S., Diaz, R. and Trainor, P.A. (2013). Cold Spring Harb Perspect Biol. 5(2).
Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis.
Barlow, A., Dixon, J., Dixon, M. and Trainor, P.A. (2013). Human Molecular Genetics 22(6):1206-17.
2012
Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-Induced Gene Expression during Neuronal Differentiation.
Yasukawa, T., Bhatt, S., Takeuchi, T., Kawauchi, J., Takahashi, H., Tsutusi, A., Muraoka, T., Inoue, M., Tsuda, A., Kitajima, S., Conaway, R.C., Conaway, J.W. Trainor, P.A., and Aso, T (2012). Cell Reports 2(5):1129-36.
Gadd45g and Map3k4 interactions regulate mouse testis determination via p38-mediated control of Sry expression.
Warr, N., Carre, G.-A., Siggers, P., Vitos, J., Brixey, R., Pope, M., Bogani, D., Childers, M., Wells, S., Scudamore, C., Nebreda, A.R., Trainor, P.A. and Greenfield, A. (2012). Developmental Cell 23(5):1020-31.
Wholemount nuclear fluorescent imaging: Convenient documentation of embryo morphology.
Sandell, L. L, Kurosaka, H. and Trainor, P.A. (2012). Genesis 50(11):844-50.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe craniofacial defects consistent with acrania-holoprosencephaly-agnathia.
Dennis, J.F., Kurosaka, H., Iulianella, A., Pace, J., Thomas, N., Beckham, S., Williams, T. and Trainor, P.A. (2012). PLOS Genetics 8(10):e1002927.
Neural crest stem cells: Discovery, properties and potential for therapy.
Achilleos, A., Trainor, P.A. (2012). Cell Research 22(2):288.304.
Balancing neural crest cell intrinsic processes with those of the microenvironment enable complete enteric nervous system formation.
Barlow, A.J., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). Human Molecular Genetics. 21(8):1782-1793.
RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse Embryogenesis.
Sandell, L.L., Lynn, M.L., Inman, K.E., McDowell, W., Trainor, P.A. (2012). PLoS ONE. 7(2):e30698.
Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells.
Sakai, D., Dixon, J., Dixon, M.J., Trainor, P.A. (2012). PLoS Genetics. 8(3):e1002566.
2011
RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.
Farjo, K.M., Moiseyev, G., Nikolaeva, O., Sandell, L.L., Trainor, P.A. and Ma J-X. (2011). Developmental Biology. 357(2):347-355.
Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models.
Kumar, S., Sandell, L.L., Trainor, P.A., Koentgen, F. and Duester, G. (2012). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821(1):198-205.
Flexibility of Neural Stem Cells.
Remboutsika, E., Elkouris M., Iulianella A., Andoniadou, C., Poulou, M., Mitsiadis, T.A., Trainor, P.A. and Lovell-Badge, R. (2011). Frontiers in Physiology 2:16.
The FaceBase Consortium: A Comprehensive Program to Facilitate Craniofacial Research.
Hochheiser, H, Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita, M.L., Murray, J.C., Murray, S., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M. and Trainor, P.A. (2011). Developmental Biology 355 (2):175-182.
Rdh10 Mutants Deficient in Limb Bud Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing.
Cunningham, T.J., Chatzi, C., Sandell, L.L., Trainor, P.A., and Duester, G. (2011). Developmental Dynamics 240(5):1142-1150.
A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.
Sandell, L.L., Iulianella, A., Melton, K. Lynn, M., Walker, Inman, K., Bhatt S, Leroux-Berger, M., Crawford, M., Jones, N., Dennis., J., Trainor, P.A. (2011). Genesis 49(4):342-359.
Electroporation of Chick and Mouse Embryos.
Crull, K. E., Su, F., Swartz, M., Eberhart, J., McLennan, R., Chen, Y. and Trainor, P.A. (2011). Imaging in Developmental Biology: A Laboratory Manual. (Sharpe, Wong, Yuste eds). CSHL Press, New York.
2010
Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.
Trainor, P.A. (2010). Am J Med Genet A. 152A(12):2984-94.
Cardiac Neural crest Cells.
Inman, K.E., Ezin, M, Bronner-Fraser, M. and Trainor, P.A. (2010). Heart Development and Regeneration Volume 1:417-434. (Rosenthal and Harvey, eds), Elsevier.
Dynamic imaging of mammalian neural tube closure.
Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. (2010). Developmental Biology 344(2):941-947.
2009
Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. (2009) Development 136(14):2329-2334.
Interfering with Wnt signalling alters the periodicity of the segmentation clock.
Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. (2009) Developmental Biology 330(1):21-31.
Treacher Collins syndrome: Unmasking the role of Tcof1/treacle.
Sakai D, Trainor PA. (2009). Int J Biochem Cell Biol. 41(6):1229-1232.
Treacher Collins syndrome: etiology, pathogenesis and prevention.
Trainor PA, Dixon J, Dixon MJ. (2009). European J Human Genetics 17:275-283.
2008
Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis.
Bogni S, Trainor P, Natarajan D, Krumlauf R, Pachnis V. (2008) Development. 135(18):3007-3011.
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA. (2008) Nature Medicine 14(2):125-133.
Comments about the paper may be found in Nat Med. 2008 Feb;14(2):115-6.
Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.
Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA. (2008) Development 135(4):729-741.
2007
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. (2007) Genes and Development 21(9):1113-1124.
2006
Neural Crest Stem and Progenitor Cells.
Crane JF, Trainor PA. (2006) Annual Rev Cell Dev Biol. 22:267-286.
Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.
Dixon J, Jones NC, Sandell LL, Jayasinghe SM, Crane J, Rey JP, Dixon MJ, Trainor PA. (2006) Proc Natl Acad Sci 103(36)13403-13408.
Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O. (2006) Developmental Cell 10(3):355-366.
2005
Relations and interactions between cranial mesoderm and neural crest populations.
Noden DM, Trainor PA. (2005) J Anatomy 207(5):575-601.
2004
Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.
Kulesa P, Ellies DL, Trainor PA. (2004) Developmental Dynamics 229(1):14-29.
2003
Somitogenesis: breaking new boundaries.
Iulianella A, Melton KR, Trainor PA. (2003) Neuron 40(1):11-14.
Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia.
Iulianella A, Vanden Heuvel G, Trainor PA. (2003) Gene Expr Patterns 3(5):571-577.
Development. The bills of qucks and duails.
Trainor, PA. (2003) Science 299(5606):523-524.
2002
Riding the crest of Wnt signaling.
Trainor PA, Krumlauf R. (2002) Science 297(5582):781-783.
Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
Trainor PA, Ariza-McNaughton L, Krumlauf R. (2002) Science 295(5558):1288-1291.
Comments about this paper may be found in Nature Reviews Neuroscience 3:254
Additional comments about this paper may be found in Nature 416: 493-494.
Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.
Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R. (2002) Development 129(2):433-442.
2001
Hox genes, neural crest cells and branchial arch patterning.
Trainor PA and Krumlauf R. (2001). Curr Opin Cell Biol 13(6):698-705
Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest.
Gavalas A, Trainor PA, Ariza-McNaughton L, Krumlauf R. (2001) Development 128(15):3017-3027.
2000
Patterning cranial neural crest: roles for hindbrain segmentation and plasticity of Hox gene expression.
Trainor PA, Krumlauf R. (2000) Nature Rev Neurosci. 1(2):116-124.
Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head.
Manzanares M, Wada H, Itasaki N, Trainor PA, Krumlauf R, Holland PW. (2000) Nature 408(6814):854-857.
Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.
Manzanares M, Trainor PA, Ariza-McNaughton L, Nonchev S, Krumlauf R. (2000) Mech Dev. 94(1-2):147-156.
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.
Golding JP, Trainor PA, Krumlauf R, Gassmann M. (2000) Nature Cell Biology 2(2):103-109.
Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
Trainor PA, Krumlauf R. (2000) Nature Cell Biology 2(2):96-102