Gene conversion generates evolutionary novelty that fuels genetic conflicts

Daugherty, M.D., Zanders S.E. Curr Opin Genet Dev. 2019; 58-59, 49-54


Dramatically diverse S. pombe wtf meiotic drivers all display high gamete-killing efficiency

Bravo Núñez M.A., Sabbarini, I.M., Eickbush M.T., Liang, Y., Lange J.J., Kent, A.M., Zanders S.E. PLoS Genet. 2020; 16 (2), e1008350.


A family of killers.

De Carvalho M., Zanders S.E. Elife. 2019; 8. pii: e49211


Fertility Costs of Meiotic Drivers.

Zanders S.E., Unckless R.L. Curr Biol. 2019; 29(11):R512-R520


Killer meiotic drive and dynamic evolution of the wtf gene family

Eickbush M.T., Young J.M., Zanders S.E. Mol Biol Evol. 2019; 36(6):1201-1214.


A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote.

Bravo Núñez M.A., Lange J.J., Zanders S.E. PLoS Genet. 2018;14(11):e1007836.


Genetic Villains: Killer Meiotic Drivers.

Bravo Núñez M.A., Nuckolls N.L., Zanders S.E. Trends Genet. 2018; 34(6):424-433.


wtf genes are prolific dual poison-antidote meiotic drivers.

Nuckolls N.L., Bravo Núñez M.A., Eickbush M.T., Young J.M., Lange J.J., Yu J.S., Smith G.R., Jaspersen S.L., Malik H.S., Zanders S.E.  eLife. 2017; 6:e26033

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Veni, vidi, vici: the success of wtf meiotic drivers in fission yeast.

Lopez Hernández, J.F., Zanders, S.E. Yeast. 2018 Jan 11. doi: 10.1002/yea.3305.


Chromosome segregation: human female meiosis breaks all the rules.

Zanders SE, Malik HS.  Curr Biol. 2015 Aug 3;25(15):R654-6. doi: 10.1016/j.cub.2015.06.054.


R2d2 and Hyperdrive Mechanisms (in Mouse Meiosis).

Zanders SE, Malik HS. PLoS Genet. 2015 Feb 13;11(2):e1004950. doi: 10.1371/journal.pgen.1004950. eCollection 2015 Feb.


Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast.

Zanders S, Eickbush MT, Yu JS, Kang JW, Fowler KR, Smith GR, Malik HS.  eLife.2014;3:e02630.


Mutation hot spots in yeast caused by long-range clustering of homopolymeric sequences.

Ma X, Rogacheva MV, Nishant KT, Zanders S, Bustamante CD, Alani E.  Cell Rep. 2012 Jan 26;1(1):36-42. doi: 10.1016/j.celrep.2011.10.003. Epub 2012 Jan 26.


Pch2 modulates chromatid partner choice during meiotic double-strand break repair in Saccharomyces cerevisiae.

Zanders S, Sonntag Brown M, Chen C, Alani E.  Genetics.2011;188:511-521.


Sustained and rapid chromosome movements are critical for chromosome pairing and meiotic progression in budding yeast.

Sonntag Brown M, Zanders S, Alani E.  Genetics. 2011 May;188(1):21-32. doi: 10.1534/genetics.110.125575. Epub 2011 Feb 21.


Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach.

Zanders S, Ma X, Roychoudhury A, Hernandez RD, Demogines A, Barker B, Gu Z, Bustamante CD, Alani E.  Genetics.2010;186:493-503.


The pch2Delta mutation in baker's yeast alters meiotic crossover levels and confers a defect in crossover interference.

Zanders S, Alani E.  PLoS genetics.2009;5:e1000571.


Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis.

Wanat JJ, Kim KP, Koszul R, Zanders S, Weiner B, Kleckner N, Alani E.  PLoS Genet. 2008 Sep 26;4(9):e1000188. doi: 10.1371/journal.pgen.1000188.







Selfish gene acts as both poison and antidote to eliminate competition

Stowers Institute Press Release, 2017 Jun 20


Heredity: The gene family that cheats Mendel

Shropsire, J. D., Rokas, A.  eLife 2017;6:e28567 doi: 10.7554/eLife.28567


‘Wtf’? A gene that poisons its own host

Rachel Tompa, Fred Hutch News Service 2017 Jun 20


The Scientist, Selfish Yeast Genes Encode Both Toxin and Antidote

Diana Kwon, The Scientist, 2017 Jun 20


wtf: a meiotic drive tragedy in 3 acts

Pineapples and Whales, 2017 Jun 20


The selfish genes that kill sex cells

Medium, 2017 Jun 20